Calcium-dependent plasma membrane binding and cell lygis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 8426-8434

  Voskoboinik, Ilia ^a   Thia, Marie Claude ^a   Fletcher, Jamie ^b   Ciccone, Annette ^a   Browne, Kylie ^a   Smyth, Mark J ^a   Trapani, Joseph A ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; IMMUNOLOGY; LIPIDS; MATHEMATICAL MODELS; MUTAGENESIS; PATHOLOGY; PERFORATING; PROTEINS; THREE DIMENSIONAL;

CELL LYGIS; CELL LYSIS; FULL LENGTH PERFORIN; PLASMA MEMBRANES;

CELL MEMBRANES;

ASPARTIC ACID; CALCIUM; PERFORIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CYTOLYSIS; HUMAN; HUMAN CELL; MEMBRANE BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; RAT;

AMINO ACID MOTIFS; ANIMALS; ASPARTIC ACID; CALCIUM; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; INSECTS; JURKAT CELLS; LIGANDS; LIPID METABOLISM; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTATION; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSFECTION;

EID: 14844321553     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413303200     Document Type: Article

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