Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

EMBO Journal

Volumn 16, Issue 24, 1997, Pages 7287-7296

  Uellner, Ruth ^a   Zvelebil, Marketa J ^b   Hopkins, Jean ^c   Jones, Jane ^c   MacDougall, Lindsay K ^b   Morgan, B Paul ^c   Podack, Eckhard ^d   Waterfield, Michael D ^a,b   Griffiths, Gillian M ^a,e  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM CHLORIDE; CALCIUM ION; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PERFORIN; PHOSPHOLIPID; PHOSPHOLIPID BINDING PROTEIN; PROTEIN PRECURSOR;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; GLYCOSYLATION; HEXOSAMINIDASES; HUMANS; ISOENZYMES; KILLER CELLS, NATURAL; LIPOSOMES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C; PHOSPHOLIPIDS; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0031464539     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.24.7287     Document Type: Article

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