메뉴 건너뛰기




Volumn 92, Issue 3 SPEC. ISS., 2009, Pages 261-273

The evolution and application of techniques in molecular biology to human brain tumors: A 25 year perspective

Author keywords

Brain tumor; Cytogenetics; DNA sequencing; Epigenetics; MicroRNAs; Molecular biology

Indexed keywords

HERPESVIRUS VECTOR; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; THYMIDINE KINASE;

EID: 65249177252     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-9829-0     Document Type: Review
Times cited : (11)

References (94)
  • 1
    • 0021887991 scopus 로고
    • Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein
    • doi: 10.1002/jcb.240280302
    • Bourdon MA, Matthews TJ, Pizzo SV, Bigner DD (1985) Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. J Cell Biochem 28:183-195. doi: 10.1002/jcb.240280302
    • (1985) J Cell Biochem , vol.28 , pp. 183-195
    • Bourdon, M.A.1    Matthews, T.J.2    Pizzo, S.V.3    Bigner, D.D.4
  • 2
    • 0020527983 scopus 로고
    • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody
    • Bourdon MA, Wikstrand CJ, Furthmayr H, Matthews TJ, Bigner DD (1983) Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. Cancer Res 43:2796-2805
    • (1983) Cancer Res , vol.43 , pp. 2796-2805
    • Bourdon, M.A.1    Wikstrand, C.J.2    Furthmayr, H.3    Matthews, T.J.4    Bigner, D.D.5
  • 3
    • 0029031343 scopus 로고
    • Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2-a preliminary report
    • doi: 10.1007/BF01052668
    • Bigner DD, Brown M, Coleman RE, Friedman AH, Friedman HS, McLendon RE, Bigner SH, Zhao XG, Wikstrand CJ, Pegram CN et al (1995) Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2-a preliminary report. J Neurooncol 24:109-122. doi: 10.1007/BF01052668
    • (1995) J Neurooncol , vol.24 , pp. 109-122
    • Bigner, D.D.1    Brown, M.2    Coleman, R.E.3    Friedman, A.H.4    Friedman, H.S.5    McLendon, R.E.6    Bigner, S.H.7    Zhao, X.G.8    Wikstrand, C.J.9    Pegram, C.N.10
  • 5
    • 0023773244 scopus 로고
    • The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice
    • doi: 10.3109/02688698808992668
    • Colapinto EV, Lee YS, Humphrey PA, Zalutsky MR, Friedman HS, Bullard DE, Bigner DD (1988) The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice. Br J Neurosurg 2:179-191. doi: 10.3109/02688698808992668
    • (1988) Br J Neurosurg , vol.2 , pp. 179-191
    • Colapinto, E.V.1    Lee, Y.S.2    Humphrey, P.A.3    Zalutsky, M.R.4    Friedman, H.S.5    Bullard, D.E.6    Bigner, D.D.7
  • 10
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • doi: 10.1038/260170a0
    • Stehelin D, Varmus HE, Bishop JM, Vogt PK (1976) DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260:170-173. doi: 10.1038/260170a0
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 11
    • 0020972413 scopus 로고
    • Cellular oncogenes and retroviruses
    • Bishop JM (1983) Cellular oncogenes and retroviruses. Ann Rev biochem 52:301-354
    • (1983) Ann Rev Biochem , vol.52 , pp. 301-354
    • Bishop, J.M.1
  • 12
    • 0025047659 scopus 로고
    • Molecular probes in neuro-oncology: A Review
    • doi: 10.3109/07357909009012060
    • Rutka JT, Trent JM, Rosenblum ML (1990) Molecular probes in neuro-oncology: A Review. Cancer Invest 8:425-438. doi: 10.3109/ 07357909009012060
    • (1990) Cancer Invest , vol.8 , pp. 425-438
    • Rutka, J.T.1    Trent, J.M.2    Rosenblum, M.L.3
  • 13
    • 0021932240 scopus 로고
    • Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
    • doi: 10.1038/313144a0
    • Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J (1985) Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313:144-147. doi: 10.1038/ 313144a0
    • (1985) Nature , vol.313 , pp. 144-147
    • Libermann, T.A.1    Nusbaum, H.R.2    Razon, N.3    Kris, R.4    Lax, I.5    Soreq, H.6    Whittle, N.7    Waterfield, M.D.8    Ullrich, A.9    Schlessinger, J.10
  • 15
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • doi: 10.1073/pnas.84.19.6899
    • Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B (1987) Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84:6899-6903. doi: 10.1073/pnas.84.19.6899
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzler, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 16
    • 0028875936 scopus 로고
    • Transfer of genes to humans: Early lessons and obstacles to success
    • doi: 10.1126/science.270.5235.404
    • Crystal RG (1995) Transfer of genes to humans: Early lessons and obstacles to success. Science 270:404-410. doi: 10.1126/ science.270.5235.404
    • (1995) Science , vol.270 , pp. 404-410
    • Crystal, R.G.1
  • 17
    • 0027595949 scopus 로고
    • The basic science of gene therapy
    • doi: 10.1126/science.8493530
    • Mulligan RC (1993) The basic science of gene therapy. Science 260:926-932. doi: 10.1126/science.8493530
    • (1993) Science , vol.260 , pp. 926-932
    • Mulligan, R.C.1
  • 18
    • 0031770243 scopus 로고    scopus 로고
    • Viral vectors for gene therapy
    • doi: 10.1016/S0163-7258(98)00020-5
    • Robbins PD, Ghivizzani SC (1998) Viral vectors for gene therapy. Pharmacol Ther 80:35-47. doi: 10.1016/S0163-7258(98)00020-5
    • (1998) Pharmacol Ther , vol.80 , pp. 35-47
    • Robbins, P.D.1    Ghivizzani, S.C.2
  • 19
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of a genetically engineered virus mutant
    • doi: 10.1126/science.1851332
    • Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM (1991) Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science 252:854-856. doi: 10.1126/ science.1851332
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3    Ruffner, K.L.4    Coen, D.M.5
  • 23
    • 2442767029 scopus 로고    scopus 로고
    • A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma
    • doi: 10.1089/hum.1998.9.17-2595
    • Klatzmann D, Valery CA, Bensimon G, Marro B, Boyer O, Mokhtari K, Diquet B, Salzmann JL, Philippon J (1998) A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum Gene Ther 9:2595-2604. doi: 10.1089/hum.1998.9.17-2595
    • (1998) Hum Gene Ther , vol.9 , pp. 2595-2604
    • Klatzmann, D.1    Valery, C.A.2    Bensimon, G.3    Marro, B.4    Boyer, O.5    Mokhtari, K.6    Diquet, B.7    Salzmann, J.L.8    Philippon, J.9
  • 24
    • 0029148876 scopus 로고
    • Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors
    • doi: 10.1089/hum.1995.6.9-1231
    • Kun LE, Gajjar A, Muhlbauer M, Heideman RL, Sanford R, Brenner M, Walter A, Langston J, Jenkins J, Facchini S (1995) Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors. Hum Gene Ther 6:1231-1255. doi: 10.1089/hum.1995.6.9-1231
    • (1995) Hum Gene Ther , vol.6 , pp. 1231-1255
    • Kun, L.E.1    Gajjar, A.2    Muhlbauer, M.3    Heideman, R.L.4    Sanford, R.5    Brenner, M.6    Walter, A.7    Langston, J.8    Jenkins, J.9    Facchini, S.10
  • 25
    • 0027548077 scopus 로고
    • Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • doi: 10.1089/hum.1993.4.1-39
    • Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anderson WF (1993) Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 4:39-69. doi: 10.1089/hum.1993.4.1-39
    • (1993) Hum Gene Ther , vol.4 , pp. 39-69
    • Oldfield, E.H.1    Ram, Z.2    Culver, K.W.3    Blaese, R.M.4    DeVroom, H.L.5    Anderson, W.F.6
  • 26
    • 0028124751 scopus 로고
    • Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system
    • doi: 10.1089/hum.1994.5.7-863
    • Raffel C, Culver K, Kohn D, Nelson M, Siegel S, Gillis F, Link CJ, Villablanca JG, Anderson WF (1994) Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum Gene Ther 5:863-890. doi: 10.1089/hum.1994.5.7-863
    • (1994) Hum Gene Ther , vol.5 , pp. 863-890
    • Raffel, C.1    Culver, K.2    Kohn, D.3    Nelson, M.4    Siegel, S.5    Gillis, F.6    Link, C.J.7    Villablanca, J.G.8    Anderson, W.F.9
  • 28
    • 0033055970 scopus 로고    scopus 로고
    • Congenital disseminated malignant rhabdoid tumor: A distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11
    • doi: 10.1097/00000478-199903000-00001
    • White FV, Dehner LP, Belchis DA, Conard K, Davis MM, Stocker JT, Zuppan CW, Biegel JA, Perlman EJ (1999) Congenital disseminated malignant rhabdoid tumor: A distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11. Am J Surg Pathol 23:249-256. doi: 10.1097/00000478-199903000-00001
    • (1999) Am J Surg Pathol , vol.23 , pp. 249-256
    • White, F.V.1    Dehner, L.P.2    Belchis, D.A.3    Conard, K.4    Davis, M.M.5    Stocker, J.T.6    Zuppan, C.W.7    Biegel, J.A.8    Perlman, E.J.9
  • 30
    • 0032415086 scopus 로고    scopus 로고
    • Chromosomal aberrations detected by comparative genomic hybridization (CGH) in human astrocytic tumors
    • doi: 10.1016/S0304-3835(98)00266-3
    • Maruno M, Yoshimine T, Muhammad AK, Ninomiya H, Kato A, Hayakawa T (1999) Chromosomal aberrations detected by comparative genomic hybridization (CGH) in human astrocytic tumors. Cancer Lett 135:61-66. doi: 10.1016/S0304-3835(98)00266-3
    • (1999) Cancer Lett , vol.135 , pp. 61-66
    • Maruno, M.1    Yoshimine, T.2    Muhammad, A.K.3    Ninomiya, H.4    Kato, A.5    Hayakawa, T.6
  • 31
    • 0033860991 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping
    • Bayani J, Zielenska M, Marrano P, Kwan Ng Y, Taylor MD, Jay V, Rutka JT, Squire JA (2000) Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg 93:437-448
    • (2000) J Neurosurg , vol.93 , pp. 437-448
    • Bayani, J.1    Zielenska, M.2    Marrano, P.3    Kwan Ng, Y.4    Taylor, M.D.5    Jay, V.6    Rutka, J.T.7    Squire, J.A.8
  • 33
    • 0036132668 scopus 로고    scopus 로고
    • Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets
    • Fuller GN, Hess KR, Rhee CH, Yung WK, Sawaya RA, Bruner JM, Zhang W (2002) Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol 12:108-116
    • (2002) Brain Pathol , vol.12 , pp. 108-116
    • Fuller, G.N.1    Hess, K.R.2    Rhee, C.H.3    Yung, W.K.4    Sawaya, R.A.5    Bruner, J.M.6    Zhang, W.7
  • 34
    • 40749111022 scopus 로고    scopus 로고
    • Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas
    • doi: 10.1158/1541-7786.MCR-07-0280
    • Li A, Walling J, Kotliarov Y, Center A, Steed ME, Ahn SJ, Rosenblum M, Mikkelsen T, Zenklusen JC, Fine HA (2008) Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Mol Cancer Res 6:21-30. doi: 10.1158/1541-7786.MCR-07-0280
    • (2008) Mol Cancer Res , vol.6 , pp. 21-30
    • Li, A.1    Walling, J.2    Kotliarov, Y.3    Center, A.4    Steed, M.E.5    Ahn, S.J.6    Rosenblum, M.7    Mikkelsen, T.8    Zenklusen, J.C.9    Fine, H.A.10
  • 35
    • 0036682413 scopus 로고    scopus 로고
    • Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma
    • Tanwar MK, Gilbert MR, Holland EC (2002) Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma. Cancer Res 62:4364-4368
    • (2002) Cancer Res , vol.62 , pp. 4364-4368
    • Tanwar, M.K.1    Gilbert, M.R.2    Holland, E.C.3
  • 36
    • 0042425741 scopus 로고    scopus 로고
    • Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
    • van den Boom J, Wolter M, Kuick R, Misek DE, Youkilis AS, Wechsler DS, Sommer C, Reifenberger G, Hanash SM (2003) Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol 163:1033-1043
    • (2003) Am J Pathol , vol.163 , pp. 1033-1043
    • van den Boom, J.1    Wolter, M.2    Kuick, R.3    Misek, D.E.4    Youkilis, A.S.5    Wechsler, D.S.6    Sommer, C.7    Reifenberger, G.8    Hanash, S.M.9
  • 38
    • 34248545443 scopus 로고    scopus 로고
    • Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation
    • doi: 10.1158/0008-5472.CAN-06-4250
    • Tsai MH, Cook JA, Chandramouli GV, DeGraff W, Yan H, Zhao S, Coleman CN, Mitchell JB, Chuang EY (2007) Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res 67:3845-3852. doi: 10.1158/0008-5472.CAN-06-4250
    • (2007) Cancer Res , vol.67 , pp. 3845-3852
    • Tsai, M.H.1    Cook, J.A.2    Chandramouli, G.V.3    DeGraff, W.4    Yan, H.5    Zhao, S.6    Coleman, C.N.7    Mitchell, J.B.8    Chuang, E.Y.9
  • 39
    • 68949135462 scopus 로고    scopus 로고
    • The role of the membrane cytoskeleton crosslinker ezrin in medulloblastoma cells
    • doi: 10.1215/15228517-2008-110
    • Osawa H, Smith C, Ra YS, Rutka JT (2009) The role of the membrane cytoskeleton crosslinker ezrin in medulloblastoma cells. Neuro-oncol. doi: 10.1215/15228517-2008-110
    • (2009) Neuro-oncol
    • Osawa, H.1    Smith, C.2    Ra, Y.S.3    Rutka, J.T.4
  • 40
    • 33750441471 scopus 로고    scopus 로고
    • Current concepts in the molecular genetics of pediatric brain tumors: Implications for emerging therapies
    • doi: 10.1007/s00381-006-0187-3
    • Tamber MS, Bansal K, Liang ML, Mainprize TG, Salhia B, Northcott P, Taylor M, Rutka JT (2006) Current concepts in the molecular genetics of pediatric brain tumors: Implications for emerging therapies. Childs Nerv Syst 22:1379-1394. doi: 10.1007/s00381-006-0187-3
    • (2006) Childs Nerv Syst , vol.22 , pp. 1379-1394
    • Tamber, M.S.1    Bansal, K.2    Liang, M.L.3    Mainprize, T.G.4    Salhia, B.5    Northcott, P.6    Taylor, M.7    Rutka, J.T.8
  • 41
    • 2342468007 scopus 로고    scopus 로고
    • Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme
    • doi: 10.1016/j.cancergencyto.2003.09.012
    • Cowell JK, Matsui S, Wang YD, LaDuca J, Conroy J, McQuaid D, Nowak NJ (2004) Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme. Cancer Genet Cytogenet 151:36-51. doi: 10.1016/j.cancergencyto.2003.09.012
    • (2004) Cancer Genet Cytogenet , vol.151 , pp. 36-51
    • Cowell, J.K.1    Matsui, S.2    Wang, Y.D.3    LaDuca, J.4    Conroy, J.5    McQuaid, D.6    Nowak, N.J.7
  • 42
    • 24944535651 scopus 로고    scopus 로고
    • Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis
    • doi: 10.1158/1078-0432.CCR-05-0128
    • Hui AB, Takano H, Lo KW, Kuo WL, Lam CN, Tong CY, Chang Q, Gray JW, Ng HK (2005) Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Clin Cancer Res 11:4707-4716. doi: 10.1158/ 1078-0432.CCR-05-0128
    • (2005) Clin Cancer Res , vol.11 , pp. 4707-4716
    • Hui, A.B.1    Takano, H.2    Lo, K.W.3    Kuo, W.L.4    Lam, C.N.5    Tong, C.Y.6    Chang, Q.7    Gray, J.W.8    Ng, H.K.9
  • 45
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer genome atlas research network doi: 10.1038/nature07385
    • Cancer genome atlas research network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068. doi: 10.1038/nature07385
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 46
    • 63449115501 scopus 로고    scopus 로고
    • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    • doi: 10.1038/ng.336
    • Northcott P, Nakahara Y, Xiaochong W, et al. (2009) Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nature Genetics. doi: 10.1038/ng.336
    • (2009) Nature Genetics
    • Northcott, P.1    Nakahara, Y.2    Xiaochong, W.3
  • 47
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • doi: 10.1101/gad.947102
    • Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21. doi: 10.1101/gad.947102
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 48
    • 35848951163 scopus 로고    scopus 로고
    • Covalent modifications of histones during development and disease pathogenesis
    • doi: 10.1038/nsmb1337
    • Bhaumik SR, Smith E, Shilatifard A (2007) Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14:1008-1016. doi: 10.1038/nsmb1337
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1008-1016
    • Bhaumik, S.R.1    Smith, E.2    Shilatifard, A.3
  • 49
    • 36549056015 scopus 로고    scopus 로고
    • Epigenetic changes in cancer
    • doi: 10.1111/j.1600-0463.2007.apm_636.xml.x
    • Gronbaek K, Hother C, Jones PA (2007) Epigenetic changes in cancer. APMIS 115:1039-1059. doi: 10.1111/j.1600-0463.2007.apm_636.xml.x
    • (2007) APMIS , vol.115 , pp. 1039-1059
    • Gronbaek, K.1    Hother, C.2    Jones, P.A.3
  • 50
    • 24344509239 scopus 로고    scopus 로고
    • TP53 promoter methylation in human gliomas
    • doi: 10.1007/s00401-005-1041-5
    • Amatya VJ, Naumann U, Weller M, Ohgaki H (2005) TP53 promoter methylation in human gliomas. Acta Neuropathol 110:178-184. doi: 10.1007/ s00401-005-1041-5
    • (2005) Acta Neuropathol , vol.110 , pp. 178-184
    • Amatya, V.J.1    Naumann, U.2    Weller, M.3    Ohgaki, H.4
  • 51
    • 0142061145 scopus 로고    scopus 로고
    • PTEN methylation and expression in glioblastomas
    • doi: 10.1007/s00401-003-0748-4
    • Baeza N, Weller M, Yonekawa Y, Kleihues P, Ohgaki H (2003) PTEN methylation and expression in glioblastomas. Acta Neuropathol 106:479-485. doi: 10.1007/s00401-003-0748-4
    • (2003) Acta Neuropathol , vol.106 , pp. 479-485
    • Baeza, N.1    Weller, M.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 54
    • 33747889966 scopus 로고    scopus 로고
    • Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma
    • doi: 10.1158/0008-5472.CAN-05-4552
    • Kim TY, Zhong S, Fields CR, Kim JH, Robertson KD (2006) Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res 66:7490-7501. doi: 10.1158/0008-5472.CAN-05-4552
    • (2006) Cancer Res , vol.66 , pp. 7490-7501
    • Kim, T.Y.1    Zhong, S.2    Fields, C.R.3    Kim, J.H.4    Robertson, K.D.5
  • 57
    • 36749086010 scopus 로고    scopus 로고
    • Epigenetic aberrations in malignant gliomas: An open door leading to better understanding and treatment
    • Martinez R, Schackert G (2007) Epigenetic aberrations in malignant gliomas: An open door leading to better understanding and treatment. Epigenetics 2:147-150
    • (2007) Epigenetics , vol.2 , pp. 147-150
    • Martinez, R.1    Schackert, G.2
  • 59
    • 57149094865 scopus 로고    scopus 로고
    • An genome wide screen identifies SPINT2 as a novel tumor suppressor silenced by methylation in medulloblastoma
    • doi: 10.1158/0008-5472.CAN-08-2169
    • Kongkham P, Northcott P, Taylor MD, Smith C, Mainprize T, Croul S, Rutka JT (2008) An genome wide screen identifies SPINT2 as a novel tumor suppressor silenced by methylation in medulloblastoma. Cancer Res 68:9945-9953. doi: 10.1158/0008-5472.CAN-08-2169
    • (2008) Cancer Res , vol.68 , pp. 9945-9953
    • Kongkham, P.1    Northcott, P.2    Taylor, M.D.3    Smith, C.4    Mainprize, T.5    Croul, S.6    Rutka, J.T.7
  • 60
    • 34147215025 scopus 로고    scopus 로고
    • Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma
    • doi: 10.1215/15228517-2006-038
    • Vibhakar R, Foltz G, Yoon JG, Field L, Lee H, Ryu GY, Pierson J, Davidson B, Madan A (2007) Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro-oncol 9:135-144. doi: 10.1215/15228517-2006-038
    • (2007) Neuro-oncol , vol.9 , pp. 135-144
    • Vibhakar, R.1    Foltz, G.2    Yoon, J.G.3    Field, L.4    Lee, H.5    Ryu, G.Y.6    Pierson, J.7    Davidson, B.8    Madan, A.9
  • 61
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • doi: 10.1016/0092-8674(93)90529-Y
    • Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854. doi: 10.1016/0092-8674(93)90529-Y
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 62
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • doi: 10.1016/0092-8674(93)90530-4
    • Wightman B, Ha I, Ruvkun G (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75:855-862. doi: 10.1016/0092-8674(93)90530-4
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 64
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • doi: 10.1016/S0092-8674(04)00045-5
    • Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297. doi: 10.1016/S0092-8674(04)00045-5
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 65
    • 28044471565 scopus 로고    scopus 로고
    • MicroRNA functions in animal development and human disease
    • doi: 10.1242/dev.02073
    • Alvarez-Garcia I, Miska EA (2005) MicroRNA functions in animal development and human disease. Development 132:4653-4662. doi: 10.1242/ dev.02073
    • (2005) Development , vol.132 , pp. 4653-4662
    • Alvarez-Garcia, I.1    Miska, E.A.2
  • 66
    • 39749110083 scopus 로고    scopus 로고
    • Small non-coding RNAs in animal development
    • doi: 10.1038/nrm2347
    • Stefani G, Slack FJ (2008) Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 9:219-230. doi: 10.1038/nrm2347
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 219-230
    • Stefani, G.1    Slack, F.J.2
  • 67
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • doi: 10.1038/nrc1997
    • Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6:857-866. doi: 10.1038/nrc1997
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 68
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • doi: 10.1038/nrc1840
    • Esquela-Kerscher A, Slack FJ (2006) Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6:259-269. doi: 10.1038/nrc1840
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 69
    • 30644475098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes
    • doi: 10.1016/j.gde.2005.12.005
    • Hammond SM (2006) MicroRNAs as oncogenes. Curr Opin Genet Dev 16:4-9. doi: 10.1016/j.gde.2005.12.005
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 4-9
    • Hammond, S.M.1
  • 73
    • 41949102707 scopus 로고    scopus 로고
    • miRiad roles for the miR-17-92 cluster in development and disease
    • doi: 10.1016/j.cell.2008.04.001
    • Mendell JT (2008) miRiad roles for the miR-17-92 cluster in development and disease. Cell 133:217-222. doi: 10.1016/j.cell.2008.04.001
    • (2008) Cell , vol.133 , pp. 217-222
    • Mendell, J.T.1
  • 74
    • 27544495514 scopus 로고    scopus 로고
    • A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    • doi: 10.1158/0008-5472.CAN-05-2352
    • Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T (2005) A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 65:9628-9632. doi: 10.1158/ 0008-5472.CAN-05-2352
    • (2005) Cancer Res , vol.65 , pp. 9628-9632
    • Hayashita, Y.1    Osada, H.2    Tatematsu, Y.3    Yamada, H.4    Yanagisawa, K.5    Tomida, S.6    Yatabe, Y.7    Kawahara, K.8    Sekido, Y.9    Takahashi, T.10
  • 76
    • 0346727383 scopus 로고    scopus 로고
    • High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma
    • doi: 10.1002/gcc.10316
    • Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A (2004) High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer 39:167-169. doi: 10.1002/gcc.10316
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 167-169
    • Metzler, M.1    Wilda, M.2    Busch, K.3    Viehmann, S.4    Borkhardt, A.5
  • 77
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • doi: 10.1158/0008-5472.CAN-05-0137
    • Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-6033. doi: 10.1158/0008-5472.CAN-05-0137
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 81
    • 35148900227 scopus 로고    scopus 로고
    • MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas
    • doi: 10.1158/0008-5472.CAN-07-1045
    • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K (2007) MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res 67:8994-9000. doi: 10.1158/ 0008-5472.CAN-07-1045
    • (2007) Cancer Res , vol.67 , pp. 8994-9000
    • Corsten, M.F.1    Miranda, R.2    Kasmieh, R.3    Krichevsky, A.M.4    Weissleder, R.5    Shah, K.6
  • 83
    • 46349109152 scopus 로고    scopus 로고
    • Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma
    • doi: 10.1007/s11060-008-9624-3
    • Pierson J, Hostager B, Fan R, Vibhakar R (2008) Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol 90:1-7. doi: 10.1007/s11060-008-9624-3
    • (2008) J Neurooncol , vol.90 , pp. 1-7
    • Pierson, J.1    Hostager, B.2    Fan, R.3    Vibhakar, R.4
  • 87
    • 37749025169 scopus 로고    scopus 로고
    • Primer: Sequencing-the next generation
    • doi: 10.1038/nmeth1155
    • Rusk N, Kiermer V (2008) Primer: Sequencing-the next generation. Nat Methods 5:15. doi: 10.1038/nmeth1155
    • (2008) Nat Methods , vol.5 , pp. 15
    • Rusk, N.1    Kiermer, V.2
  • 93
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • doi: 10.1038/nmeth.1226
    • Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621-628. doi: 10.1038/nmeth.1226
    • (2008) Nat Methods , vol.5 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 94
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • doi: 10.1038/ng.259
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40:1413-1415. doi: 10.1038/ng.259
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.