Interaction of monocarboxylate transporter 4 with β1- integrin and its role in cell migration

American Journal of Physiology - Cell Physiology

Volumn 296, Issue 3, 2009, Pages

  Gallagher, Shannon M ^a   Castorino, John J ^a   Philp, Nancy J ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

CD147; MCT4

Indexed keywords

BETA1 INTEGRIN; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4; BSG PROTEIN, HUMAN; CD147 ANTIGEN; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; ASSAY; BASOLATERAL MEMBRANE; CELL LINE; CELL MIGRATION; CELL SIZE; CONTROLLED STUDY; EPITHELIUM CELL; FOCAL ADHESION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; WOUND; ANIMAL; CELL MEMBRANE; CELL MOTION; CELL POLARITY; DOG; GENETICS; METABOLISM; PROTEIN TRANSPORT; PSEUDOPODIUM; RNA INTERFERENCE; WOUND HEALING;

ANIMALS; ANTIGENS, CD147; ANTIGENS, CD29; CELL LINE; CELL MEMBRANE; CELL MOVEMENT; CELL POLARITY; DOGS; EPITHELIAL CELLS; FOCAL ADHESIONS; HUMANS; IMMUNOPRECIPITATION; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; PROTEIN TRANSPORT; PSEUDOPODIA; RNA INTERFERENCE; RNA, SMALL INTERFERING; WOUND HEALING;

EID: 65249168811     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00430.2008     Document Type: Article

References (60)

1. Ahmed N, Riley C, Rice G, Quinn M. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. Clin Exp Metastasis 22: 391-402, 2005. (Pubitemid 41609298)
2. Beningo KA, Dembo M, Kaverina I, Small JV, Wang YL. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol 153: 881-888, 2001. (Pubitemid 34286117)
3. Berditchevski F, Chang S, Bodorova J, Hemler ME. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem 272: 29174-29180, 1997.
4. Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, Kataoka H, Nabeshima K. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 55: 434-439, 1995.
5. + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 279: 26991-27007, 2004.
6. Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci 118: 889-899, 2005. (Pubitemid 40484881)
7. Charteris DG, Sethi CS, Lewis GP, Fisher SK. Proliferative vitreoretinopathy- developments in adjunctive treatment and retinal pathology. Eye 16: 369-374, 2002.
8. Chen X, Lin J, Kanekura T, Su J, Lin W, Xie H, Wu Y, Li J, Chen M, Chang J. A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 66: 11323-11330, 2006. (Pubitemid 46009963)
9. Chen X, Su J, Chang J, Kanekura T, Li J, Kuang YH, Peng S, Yang F, Lu H, Zhang JL. Inhibition of CD147 gene expression via RNA interference reduces tumor cell proliferation, activation, adhesion, and migration activity in the human Jurkat T-lymphoma cell line. Cancer Invest 26: 689-697, 2008.
10. Cho JY, Fox DA, Horejsi V, Sagawa K, Skubitz KM, Katz DR, Chain B. The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. Blood 98: 374-382, 2001.
11. Curtin KD, Meinertzhagen IA, Wyman RJ. Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci 118: 2649-2660, 2005.
12. Daniele LL, Sauer B, Gallagher SM, Pugh EN Jr, Philp NJ. Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice. Am J Physiol Cell Physiol 295: C451-C457, 2008. (Pubitemid 352755765)
13. Denker SP, Barber DL. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol 159: 1087-1096, 2002. (Pubitemid 36055762)
14. Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci USA 102: 16245-16250, 2005. (Pubitemid 41688899)
15. Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 350: 219-227, 2000.
16. Edward M, Gillan C, Micha D, Tammi RH. Tumour regulation of fibroblast hyaluronan expression: a mechanism to facilitate tumour growth and invasion. Carcinogenesis 26: 1215-1223, 2005. (Pubitemid 41417898)
17. Enerson BE, Drewes LR. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci 92: 1531-1544, 2003.
18. Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol 166: 209-219, 2005. (Pubitemid 40051673)
19. Gallagher SM, Castorino JJ, Wang D, Philp NJ. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67: 4182-4189, 2007. (Pubitemid 46815064)
20. Giannelli G, Bergamini C, Fransvea E, Marinosci F, Quaranta V, Antonaci S. Human hepatocellular carcinoma (HCC) cells require both alpha3beta1-integrin and matrix metalloproteinases activity for migration and invasion. Lab Invest 81: 613-627, 2001. (Pubitemid 32298807)
21. Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflügers Arch 447: 619-628, 2004. (Pubitemid 38241446)
22. Hergott GJ, Nagai H, Kalnins VI. Inhibition of retinal pigment epithelial cell migration and proliferation with monoclonal antibodies against the beta 1-integrin subunit during wound healing in organ culture. Invest Ophthalmol Vis Sci 34: 2761-2768, 1993.
23. Hertz L, Dienel GA. Lactate transport and transporters: general principles and functional roles in brain cells. J Neurosci Res 79: 11-18, 2005. (Pubitemid 40116412)
24. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558, 2005. (Pubitemid 41267170)
25. Juel C, Halestrap AP. Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J Physiol 517: 633-642, 1999.
26. Kanaan A, Douglas RM, Alper SL, Boron WF, Haddad GG. Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol 293: R1294-R1302, 2007. (Pubitemid 47358954)
27. Kim IK, Arroyo JG. Mechanisms in proliferative vitreoretinopathy. Ophthalmol Clin North Am 15: 81-86, 2002. (Pubitemid 34579205)
28. Kim JW, Dang CV. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 30: 142-150, 2005. (Pubitemid 40332530)
29. Kirchhof B. Strategies to influence PVR development. Graefes Arch Clin Exp Ophthalmol 242: 699-703, 2004.
30. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19: 3896-3904, 2000. (Pubitemid 30608530)
31. Luo Y, He DL, Ning L, Shen SL, Li L, Li X. Hypoxia-inducible factor-1alpha induces the epithelial-mesenchymal transition of human prostate cancer cells. Chin Med J (Engl) 119: 713-718, 2006. (Pubitemid 43796824)
32. Marieb EA, Zoltan-Jones A, Li R, Misra S, Ghatak S, Cao J, Zucker S, Toole BP. Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res 64: 1229-1232, 2004. (Pubitemid 38235586)
33. Menko AS, Philip NJ. Beta 1-integrins in epithelial tissues: a unique distribution in the lens. Exp Cell Res 218: 516-521, 1995.
34. Nabeshima K, Iwasaki H, Koga K, Hojo H, Suzumiya J, Kikuchi M. Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 56: 359-367, 2006. (Pubitemid 43886799)
35. Pakula R, Melchior A, Denys A, Vanpouille C, Mazurier J, Allain F. Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis. Glycobiology 17: 492-503, 2007. (Pubitemid 47049937)
36. Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci 44: 1305-1311, 2003. (Pubitemid 36297854)
37. Philp NJ, Wang D, Yoon H, Hjelmeland LM. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Invest Ophthalmol Vis Sci 44: 1716-1721, 2003. (Pubitemid 36378602)
38. Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, Rodrigues M, Alves VA, Schmitt F, Baltazar F. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch 452: 139-146, 2008.
39. Pullar CE, Grahn JC, Liu W, Isseroff RR. Beta2-adrenergic receptor activation delays wound healing. FASEB J 20: 76-86, 2006. (Pubitemid 43100478)
40. Riethdorf S, Reimers N, Assmann V, Kornfeld JW, Terracciano L, Sauter G, Pantel K. High incidence of EMMPRIN expression in human tumors. Int J Cancer 119: 1800-1810, 2006. (Pubitemid 44356836)
41. Schreiner A, Ruonala M, Jakob V, Suthaus J, Boles E, Wouters F, Starzinski-Powitz A. Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. Mol Biol Cell 18: 1272-1281, 2007. (Pubitemid 46626622)
42. Sienel W, Polzer B, Elshawi K, Lindner M, Morresi-Hauf A, Vay C, Eder F, Passlick B, Klein CA. Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Mod Pathol 21: 1130-1138, 2008.
43. Srivastava J, Barreiro G, Groscurth S, Gingras AR, Goult BT, Critchley DR, Kelly MJ, Jacobson MP, Barber DL. Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. Proc Natl Acad Sci USA 105: 14436-14441, 2008.
44. Stern R, Shuster S, Neudecker BA, Formby B. Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 276: 24-31, 2002.
45. + exchange. J Physiol 567: 225-238, 2005.
46. Stock C, Mueller M, Kraehling H, Mally S, Noel J, Eder C, Schwab A. pH nanoenvironment at the surface of single melanoma cells. Cell Physiol Biochem 20: 679-686, 2007. (Pubitemid 47340628)
47. Stock C, Schwab A. Role of the Na/H exchanger NHE1 in cell migration. Acta Physiol (Oxf) 187: 149-157, 2006.
48. Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 26: 299-310, 2007.
49. Toole BP, Slomiany MG. Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells. Semin Cancer Biol 18: 244-250, 2008.
50. Trabold O, Wagner S, Wicke C, Scheuenstuhl H, Hussain MZ, Rosen N, Seremetiev A, Becker HD, Hunt TK. Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen 11: 504-509, 2003. (Pubitemid 37467735)
51. Tsuji T. Physiological and pathological roles of alpha3beta1-integrin. J Membr Biol 200: 115-132, 2004.
52. Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281: 9030-9037, 2006. (Pubitemid 43864615)
53. Walenta S, Mueller-Klieser WF. Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 14: 267-274, 2004. (Pubitemid 38903231)
54. Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol 109: 877-889, 1989. (Pubitemid 19197045)
55. Xu D, Hemler ME. Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics 4: 1061-1071, 2005.
56. Yan L, Zucker S, Toole BP. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost 93: 199-204, 2005. (Pubitemid 40253722)
57. Yoon H, Fanelli A, Grollman EF, Philp NJ. Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium. Biochem Biophys Res Commun 234: 90-94, 1997. (Pubitemid 27267538)
58. Zhou S, Zhou H, Walian PJ, Jap BK. The discovery and role of CD147 as a subunit of gamma-secretase complex. Drug News Perspect 19: 133-138, 2006. (Pubitemid 43886094)
59. Zhou S, Zhou H, Walian PJ, Jap BK. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci USA 102: 7499-7504, 2005. (Pubitemid 40741000)
60. Zou W, Yang H, Hou X, Zhang W, Chen B, Xin X. Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells. Cancer Lett 248: 211-218, 2007. (Pubitemid 46330554)