Human hepatocellular carcinoma (HCC) cells require both α3β1 integrin and matrix metalloproteinases activity for migration and invasion

Laboratory Investigation

Volumn 81, Issue 4, 2001, Pages 613-627

  Giannelli, Gianluigi ^a   Bergamini, Carlo ^a   Fransvea, Emilia ^a   Marinosci, Felice ^a   Quaranta, Vito ^a,b   Antonaci, Salvatore ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; COLLAGEN TYPE 4; GELATINASE A; INTEGRIN; INTERSTITIAL COLLAGENASE; KALININ; MATRIGEL; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CANCER CELL; CANCER INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

EID: 0035044816     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780270     Document Type: Article

References (54)

1. A rapid in vitro assay for quantitating the invasive potential of tumor cells
2. Laminin-5 and hemidesmosomes: Role of the alpha 3 chain subunit in hemidesmosome stability and assembly
3. Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types
4. Localization of the alpha 3 beta 1 integrin in some common epithelial tumors of the ovary and in normal equivalents
5. Basement membrane production by hepatocytes in chronic liver disease
6. Polarization of the alpha 6 beta 4 integrin in ovarian carcinomas
7. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis
8. A new nomenclature for the laminins
9. Natural history of hepatocellular carcinoma in Spain. Five year's experience in 249 cases
10. Membrane proteases: Roles in tissue remodeling and tumour invasion
11. Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin
12. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma
13. Matrix metalloproteinases and the development of cancer
14. Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2
15. Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B
16. Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): Characterization of complex and free enzyme
17. Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells
18. Altered expression of basement membrane proteins and their integrin receptors in lichen planus: Possible pathogenetic role of gelatinases A and B
19. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
20. Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids
21. Psoriatic lesions in patients with chronic liver disease are distinct from psoriasis vulgaris lesions, as judged on basis of integrin adhesion receptors
22. Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2
23. Integrins: A family of cell surface receptors
24. Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate
25. A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors
26. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma
27. Molecular insights into cancer invasion: Strategies for prevention and intervention
28. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
29. Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells
30. Functions of alpha3beta1 integrin
31. Anti-alpha3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells
32. Alpha3beta1-integrin as a critical mediator of the hepatic differentiation response to the extracellular matrix
33. The alpha 3 beta 1 integrin is involved in melanoma cell migration and invasion
34. Kalinin is abnormally expressed in epithelial basement membranes of Herlitz's junctional epidermolysis bullosa patients
35. Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein
36. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells
37. Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors
38. The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity
39. Proteolysis and cell migration: Creating a path?
40. Activation mechanisms of matrix metalloproteinases
41. alpha6beta1 integrin expression in hepatocarcinoma cells: Regulation and role in cell adhesion and migration
42. Production and characterization of two monoclonal antibodies directed against the integrin beta 1 chain
43. Changes in expression of monoclonal antibody epitopes on laminin-5r induced by cell contact
44. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas
45. Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines
46. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression
47. Integrins and tumor cell dissemination
48. Fibrolamellar carcinoma of the liver: Composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules
49. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
50. Tumor cell interactions with the extracellular matrix during invasion and metastasis
51. Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2)
52. The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant
53. Prognostic factors after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis