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Volumn 55, Issue 1-3, 2009, Pages 28-34

Distinct expression and regulation of the glutamate transporter isoforms GLT-1a and GLT-1b in cultured astrocytes from a rat model of amyotrophic lateral sclerosis (hSOD1G93A)

Author keywords

Amyotrophic lateral sclerosis; Cortical astrocytes; GLT 1a and GL 1b; hSOD1G93A rats; Peptide Histidine Isoleucine

Indexed keywords

ASPARTIC ACID; COPPER ZINC SUPEROXIDE DISMUTASE; DEXTRO ASPARTIC ACID; MESSENGER RNA; PEPTIDE HISTIDINE ISOLEUCINE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 1 A; VESICULAR GLUTAMATE TRANSPORTER 1 B;

EID: 64949105785     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.02.003     Document Type: Article
Times cited : (14)

References (44)
  • 1
    • 0031957298 scopus 로고    scopus 로고
    • Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis
    • Aoki M., Lin C.L., Rothstein J.D., Geller B.A., Hosler B.A., Munsat T.L., Horvitz H.R., and Brown Jr. R.H. Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. Ann. Neurol. 43 (1998) 645-653
    • (1998) Ann. Neurol. , vol.43 , pp. 645-653
    • Aoki, M.1    Lin, C.L.2    Rothstein, J.D.3    Geller, B.A.4    Hosler, B.A.5    Munsat, T.L.6    Horvitz, H.R.7    Brown Jr., R.H.8
  • 2
  • 4
    • 25444440056 scopus 로고    scopus 로고
    • Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization
    • Berger U.V., DeSilva T.M., Chen W., and Rosenberg P.A. Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization. J. Comp. Neurol. 492 (2005) 78-89
    • (2005) J. Comp. Neurol. , vol.492 , pp. 78-89
    • Berger, U.V.1    DeSilva, T.M.2    Chen, W.3    Rosenberg, P.A.4
  • 5
    • 0029884012 scopus 로고    scopus 로고
    • Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex
    • Bristol L.A., and Rothstein J.D. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Ann. Neurol. 39 (1996) 676-679
    • (1996) Ann. Neurol. , vol.39 , pp. 676-679
    • Bristol, L.A.1    Rothstein, J.D.2
  • 6
    • 0034121133 scopus 로고    scopus 로고
    • Neuronal release of vasoactive intestinal peptide is important to astrocytic protection of neurons from glutamate toxicity
    • Brown D.R. Neuronal release of vasoactive intestinal peptide is important to astrocytic protection of neurons from glutamate toxicity. Mol. Cell Neurosci. 15 (2000) 465-475
    • (2000) Mol. Cell Neurosci. , vol.15 , pp. 465-475
    • Brown, D.R.1
  • 7
    • 0037088930 scopus 로고    scopus 로고
    • Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain
    • Chen W., Aoki C., Mahadomrongkul V., Gruber C.E., Wang G.J., Blitzblau R., Irwin N., and Rosenberg P.A. Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J. Neurosci. 22 (2002) 2142-2152
    • (2002) J. Neurosci. , vol.22 , pp. 2142-2152
    • Chen, W.1    Aoki, C.2    Mahadomrongkul, V.3    Gruber, C.E.4    Wang, G.J.5    Blitzblau, R.6    Irwin, N.7    Rosenberg, P.A.8
  • 9
  • 10
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: implications for therapy
    • Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Ther. 81 (1999) 163-221
    • (1999) Pharmacol. Ther. , vol.81 , pp. 163-221
    • Doble, A.1
  • 11
    • 0035020941 scopus 로고    scopus 로고
    • Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis
    • Flowers J.M., Powell J.F., Leigh P.N., Andersen P., and Shaw C.E. Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis. Ann. Neurol. 49 (2001) 643-649
    • (2001) Ann. Neurol. , vol.49 , pp. 643-649
    • Flowers, J.M.1    Powell, J.F.2    Leigh, P.N.3    Andersen, P.4    Shaw, C.E.5
  • 12
    • 0031879593 scopus 로고    scopus 로고
    • The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study
    • Fray A.E., Ince P.G., Banner S.J., Milton I.D., Usher P.A., Cookson M.R., and Shaw P.J. The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study. Eur. J. Neurosci. 10 (1998) 2481-2489
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2481-2489
    • Fray, A.E.1    Ince, P.G.2    Banner, S.J.3    Milton, I.D.4    Usher, P.A.5    Cookson, M.R.6    Shaw, P.J.7
  • 13
    • 37349063346 scopus 로고    scopus 로고
    • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1
    • Fumagalli E., Funicello M., Rauen T., Gobbi M., and Mennini T. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur. J. Pharmacol. 578 (2008) 171-176
    • (2008) Eur. J. Pharmacol. , vol.578 , pp. 171-176
    • Fumagalli, E.1    Funicello, M.2    Rauen, T.3    Gobbi, M.4    Mennini, T.5
  • 14
    • 42549096031 scopus 로고    scopus 로고
    • Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake
    • Goursaud S., Maloteaux J.M., and Hermans E. Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake. J. Neurochem. 105 (2008) 1165-1175
    • (2008) J. Neurochem. , vol.105 , pp. 1165-1175
    • Goursaud, S.1    Maloteaux, J.M.2    Hermans, E.3
  • 15
    • 61349112773 scopus 로고    scopus 로고
    • Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties
    • Goursaud S., Kozlova E.N., Maloteaux J.M., and Hermans E. Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties. J. Neurochem. 108 (2009) 1442-1452
    • (2009) J. Neurochem. , vol.108 , pp. 1442-1452
    • Goursaud, S.1    Kozlova, E.N.2    Maloteaux, J.M.3    Hermans, E.4
  • 17
    • 0034711151 scopus 로고    scopus 로고
    • Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls
    • Honig L.S., Chambliss D.D., Bigio E.H., Carroll S.L., and Elliott J.L. Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls. Neurology 55 (2000) 1082-1088
    • (2000) Neurology , vol.55 , pp. 1082-1088
    • Honig, L.S.1    Chambliss, D.D.2    Bigio, E.H.3    Carroll, S.L.4    Elliott, J.L.5
  • 19
    • 0035399466 scopus 로고    scopus 로고
    • +-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1
    • +-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1. J. Membr. Biol. 182 (2001) 17-30
    • (2001) J. Membr. Biol. , vol.182 , pp. 17-30
    • Kimmich, G.A.1    Roussie, J.2    Manglapus, M.3    Randles, J.4
  • 20
    • 33746531118 scopus 로고    scopus 로고
    • Reversed actrocytic GLT-1 during ischemia is crucial to excitotoxic death of neurons, but contributes to the survival of astrocytes themselves
    • Kosugi T., and Kawahara K. Reversed actrocytic GLT-1 during ischemia is crucial to excitotoxic death of neurons, but contributes to the survival of astrocytes themselves. Neurochem. Res. 31 (2006) 933-943
    • (2006) Neurochem. Res. , vol.31 , pp. 933-943
    • Kosugi, T.1    Kawahara, K.2
  • 21
    • 20444482538 scopus 로고    scopus 로고
    • A procedure for culturing astrocytes from white matter and the application of the siRNA technique for silencing the expression of their specific marker, S100A4
    • Kozlova E.N., and Takenaga K. A procedure for culturing astrocytes from white matter and the application of the siRNA technique for silencing the expression of their specific marker, S100A4. Brain Res. Brain Res. Protoc. 15 (2005) 59-65
    • (2005) Brain Res. Brain Res. Protoc. , vol.15 , pp. 59-65
    • Kozlova, E.N.1    Takenaga, K.2
  • 22
    • 33645847822 scopus 로고    scopus 로고
    • Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype
    • Li L.B., Toan S.V., Zelenaia O., Watson D.J., Wolfe J.H., Rothstein J.D., and Robinson M.B. Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. J. Neurochem. 97 (2006) 759-771
    • (2006) J. Neurochem. , vol.97 , pp. 759-771
    • Li, L.B.1    Toan, S.V.2    Zelenaia, O.3    Watson, D.J.4    Wolfe, J.H.5    Rothstein, J.D.6    Robinson, M.B.7
  • 23
    • 0032032013 scopus 로고    scopus 로고
    • Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
    • Lin C.L., Bristol L.A., Jin L., Dykes-Hoberg M., Crawford T., Clawson L., and Rothstein J.D. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 20 (1998) 589-602
    • (1998) Neuron , vol.20 , pp. 589-602
    • Lin, C.L.1    Bristol, L.A.2    Jin, L.3    Dykes-Hoberg, M.4    Crawford, T.5    Clawson, L.6    Rothstein, J.D.7
  • 24
    • 1642371041 scopus 로고    scopus 로고
    • Altered expression of the glutamate transporter EAAT2b in neurological disease
    • Maragakis N.J., Dykes-Hoberg M., and Rothstein J.D. Altered expression of the glutamate transporter EAAT2b in neurological disease. Ann. Neurol. 55 (2004) 469-477
    • (2004) Ann. Neurol. , vol.55 , pp. 469-477
    • Maragakis, N.J.1    Dykes-Hoberg, M.2    Rothstein, J.D.3
  • 25
    • 1842524064 scopus 로고    scopus 로고
    • Glutamate transporters: animal models to neurologic disease
    • Maragakis N.J., and Rothstein J.D. Glutamate transporters: animal models to neurologic disease. Neurobiol. Dis. 15 (2004) 461-473
    • (2004) Neurobiol. Dis. , vol.15 , pp. 461-473
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 27
    • 0032549709 scopus 로고    scopus 로고
    • Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients
    • Nagai M., Abe K., Okamoto K., and Itoyama Y. Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients. Neurosci. Lett. 244 (1998) 165-168
    • (1998) Neurosci. Lett. , vol.244 , pp. 165-168
    • Nagai, M.1    Abe, K.2    Okamoto, K.3    Itoyama, Y.4
  • 28
    • 0035575761 scopus 로고    scopus 로고
    • Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease
    • Nagai M., Aoki M., Miyoshi I., Kato M., Pasinelli P., Kasai N., Brown Jr. R.H., and Itoyama Y. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J. Neurosci. 21 (2001) 9246-9254
    • (2001) J. Neurosci. , vol.21 , pp. 9246-9254
    • Nagai, M.1    Aoki, M.2    Miyoshi, I.3    Kato, M.4    Pasinelli, P.5    Kasai, N.6    Brown Jr., R.H.7    Itoyama, Y.8
  • 33
    • 0033938202 scopus 로고    scopus 로고
    • Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
    • Sasaki S., Komori T., and Iwata M. Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis. Acta Neuropathol. 100 (2000) 138-144
    • (2000) Acta Neuropathol. , vol.100 , pp. 138-144
    • Sasaki, S.1    Komori, T.2    Iwata, M.3
  • 34
    • 0037126986 scopus 로고    scopus 로고
    • A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system
    • Schmitt A., Asan E., Lesch K.P., and Kugler P. A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Neuroscience 109 (2002) 45-61
    • (2002) Neuroscience , vol.109 , pp. 45-61
    • Schmitt, A.1    Asan, E.2    Lesch, K.P.3    Kugler, P.4
  • 35
    • 33847330077 scopus 로고    scopus 로고
    • Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients
    • Shobha K., Vijayalakshmi K., Alladi P.A., Nalini A., Sathyaprabha T.N., and Raju T.R. Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients. J. Neurol. Sci. 254 (2007) 9-16
    • (2007) J. Neurol. Sci. , vol.254 , pp. 9-16
    • Shobha, K.1    Vijayalakshmi, K.2    Alladi, P.A.3    Nalini, A.4    Sathyaprabha, T.N.5    Raju, T.R.6
  • 36
    • 0029810307 scopus 로고    scopus 로고
    • Siddique, T., Deng, H.X., 1996. Genetics of amyotrophic lateral sclerosis. Hum. Mol. Genet., 1465-1470 (5 Spec No.).
    • Siddique, T., Deng, H.X., 1996. Genetics of amyotrophic lateral sclerosis. Hum. Mol. Genet., 1465-1470 (5 Spec No.).
  • 37
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • Tilleux S., and Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res. 85 (2007) 2059-2070
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 38
    • 0345825889 scopus 로고    scopus 로고
    • Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress
    • Tortarolo M., Crossthwaite A.J., Conforti L., Spencer J.P., Williams R.J., Bendotti C., and Rattray M. Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. J. Neurochem. 88 (2004) 481-493
    • (2004) J. Neurochem. , vol.88 , pp. 481-493
    • Tortarolo, M.1    Crossthwaite, A.J.2    Conforti, L.3    Spencer, J.P.4    Williams, R.J.5    Bendotti, C.6    Rattray, M.7
  • 39
    • 0035808437 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
    • Trotti D., Aoki M., Pasinelli P., Berger U.V., Danbolt N.C., Brown Jr. R.H., and Hediger M.A. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. J. Biol. Chem. 276 (2001) 576-582
    • (2001) J. Biol. Chem. , vol.276 , pp. 576-582
    • Trotti, D.1    Aoki, M.2    Pasinelli, P.3    Berger, U.V.4    Danbolt, N.C.5    Brown Jr., R.H.6    Hediger, M.A.7
  • 40
    • 33751229311 scopus 로고    scopus 로고
    • The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    • Van den Bosch L., Van Damme P., Bogaert E., and Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim. Biophys. Acta 1762 (2006) 1068-1082
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 1068-1082
    • Van den Bosch, L.1    Van Damme, P.2    Bogaert, E.3    Robberecht, W.4
  • 41
    • 33645106746 scopus 로고    scopus 로고
    • Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis
    • Vermeiren C., de Hemptinne I., Vanhoutte N., Tilleux S., Maloteaux J.M., and Hermans E. Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. J. Neurochem. 96 (2006) 719-731
    • (2006) J. Neurochem. , vol.96 , pp. 719-731
    • Vermeiren, C.1    de Hemptinne, I.2    Vanhoutte, N.3    Tilleux, S.4    Maloteaux, J.M.5    Hermans, E.6
  • 42
    • 14544295726 scopus 로고    scopus 로고
    • Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation
    • Vermeiren C., Najimi M., Maloteaux J.M., and Hermans E. Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation. Neurochem. Int. 46 (2005) 137-147
    • (2005) Neurochem. Int. , vol.46 , pp. 137-147
    • Vermeiren, C.1    Najimi, M.2    Maloteaux, J.M.3    Hermans, E.4
  • 43
    • 11144341966 scopus 로고    scopus 로고
    • Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury
    • Yi J.H., Pow D.V., and Hazell A.S. Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury. Glia 49 (2005) 121-133
    • (2005) Glia , vol.49 , pp. 121-133
    • Yi, J.H.1    Pow, D.V.2    Hazell, A.S.3
  • 44
    • 27144441829 scopus 로고    scopus 로고
    • Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions
    • Zschocke J., Bayatti N., Clement A.M., Witan H., Figiel M., Engele J., and Behl C. Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions. J. Biol. Chem. 280 (2005) 34924-34932
    • (2005) J. Biol. Chem. , vol.280 , pp. 34924-34932
    • Zschocke, J.1    Bayatti, N.2    Clement, A.M.3    Witan, H.4    Figiel, M.5    Engele, J.6    Behl, C.7


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