Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

Annals of Neurology

Volumn 39, Issue 5, 1996, Pages 676-679

  Bristol, Lynn A ^a   Rothstein, Jeffrey D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; RECEPTOR SUBTYPE;

AMINO ACID TRANSPORT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MOTOR CORTEX; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSLATION REGULATION;

AGE FACTORS; AGED; AMINO ACID TRANSPORT SYSTEM X-AG; AMYOTROPHIC LATERAL SCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; AUTOPSY; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; RECEPTORS, NEUROTRANSMITTER; RNA, MESSENGER;

EID: 0029884012     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410390519     Document Type: Article

References (25)

1. Rothstein JD, Martin LJ, Kuncl RW. Decreased brain and spinal cord glutamate transport in amyotrophic lateral sclerosis. N Engl J Med 1992;326:1464-1468
2. Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic glutamate uptake inhibition produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993;90:6591-6595
3. Shaw PJ. Excitocoxicity and motor neuron disease: a review of the evidence. J Neurol Sci 1994;124(Suppl):6-13
4. Bowling AC, Schultz JB, Brown RB, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993;61:2322-2325
5. Lee MK, Marszalek JR, Cleveland DW. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of motor neuron disease. Neuron 1994;13:975-988
6. Figlewicz DA, Krizus A, Martinoli MG, et al. Variants of heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum Mol Genet 1994;3:1757-1761
7. Smith RG, Appel SH. Molecular approaches to amyotrophic lateral sclerosis. Annu Rev Med 1995;46:133-145
8. 3H]D-Aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. Brain Res 1994;655:195-201
9. +-dependent glutamate/ aspartate transporter from rat brain. Proc Natl Acad Sci USA 1992;89:10955-10959
10. Pines G, Danbolt NC, Bjoras M, et al. Cloning and expression of a rat brain I-glutamate transporter. Nature 1992;360:464-467
11. Kanai Y, Hediger M. Primary structure and functional characterization of a high affinity glutamate transporter. Nature 1992; 360:467-471
12. Arriza JL, Fairman WA, Wadiche JI, et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 1994;14:5559-5569
13. Rothstein JD, Martin L, Levey AI, et al. Localization of neuronal and glial glutamate transporters. Neuron 1994;13:713-725
14. Rothstein JD, Van Kammen M, Levey AI, et al. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84
15. Lehre KP, Levy LM, Ottersen OP, et al. Differential expression of two glutamate transporters in rat brain: quantitative and immunocytochemical observations. J Neurosci 1995;15:1835-1853
16. Bristol LA, Durum SK, Eisenberg SP. Differential regulation of group A streptococcal peptidoglycan-polysaccharide (PG-APS)-stimulated macrophage production of IL-1 by rat strains susceptible and resistant to PG-APS-induced arthritis. Cell Immunol 1993;149:130-143
17. Nicholls D, Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol Sci 1990;11:462-468
18. Kanai Y, Nussberger S, Romero MF, et al. Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter. J Biol Chem 1995;270:16561-16568
19. Fairman WA, Vandenberg RJ, Arriza JL, et al. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 1995;375:599-603
20. Shaw PJ, Forrest V, Ince PG, et al. CSF and plasma amino acid levels in motor neuron disease - elevation of CSF glutamate in a subset of patients. Neurodegeneration 1995;4:209-216
21. Rothstein JD, Tsai G, Kuncl RW, et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:15-25
22. Borchelt DR, Lee MK, Slunt HH, et al. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci USA 1995; 91:8292-8296
23. Oliver CN, Starke-Reed PE, Stadtman ER, et al. Oxidative damage to proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci USA 1990; 87:5144-5147
24. Volterra A, Trotti D, Troma C, et al. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 1994;14:2924-2932
25. Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996 (in press)