Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties

Journal of Neurochemistry

Volumn 108, Issue 6, 2009, Pages 1442-1452

  Goursaud, Stéphanie ^a   Kozlova, Elena N ^b   Maloteaux, Jean Marie ^a   Hermans, Emmanuel ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Astroglial activation; Glutamate transporter 1; Glutamate aspartate transporter; Intermediate filaments; Metabotropic glutamate 5 receptor; White matter astrocytes

Indexed keywords

CALCIUM; EXCITATORY AMINO ACID TRANSPORTER; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE AMMONIA LIGASE; METABOTROPIC RECEPTOR 5; NESTIN; VESICULAR GLUTAMATE TRANSPORTER 1; VIMENTIN;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ACTIVATION; CELL DENSITY; CELL FUNCTION; CELL POPULATION; CELL STRUCTURE; CONTROLLED STUDY; CORPUS CALLOSUM; EXCITOTOXICITY; FEMALE; GLIA CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL;

ACTINS; AMINO ACID TRANSPORT SYSTEMS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID; ASTROCYTES; CALCIUM; CELL SIZE; CELLS, CULTURED; CEREBRAL CORTEX; CORPUS CALLOSUM; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; INTERMEDIATE FILAMENT PROTEINS; NERVE TISSUE PROTEINS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; TRANSFECTION; VIMENTIN;

EID: 61349112773     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05889.x     Document Type: Article

References (45)

1. Anderson C. M. Swanson R. A. (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32, 1 14.
2. Aronica E., van Vliet E. A., Mayboroda O. A., Troost D., da Silva F. H. Gorter J. A. (2000) Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy. Eur. J. Neurosci. 12, 2333 2344.
3. Aronica E., Catania M. V., Geurts J., Yankaya B. Troost D. (2001) Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes. Neuroscience 105, 509 520.
4. Aronica E., Gorter J. A., Ijlst-Keizers H., Rozemuller A. J., Yankaya B., Leenstra S. Troost D. (2003) Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur. J. Neurosci. 17, 2106 2118.
5. Arriza J. L., Fairman W. A., Wadiche J. I., Murdoch G. H., Kavanaugh M. P. Amara S. G. (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14, 5559 5569.
6. Atkinson P. J., Young K. W., Ennion S. J., Kew J. N., Nahorski S. R. Challiss R. A. (2006) Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling. Mol. Pharmacol. 69, 174 184.
7. Baltan S., Besancon E. F., Mbow B., Ye Z., Hamner M. A. Ransom B. R. (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J. Neurosci. 28, 1479 1489.
8. Beart P. M. O'shea R. D. (2007) Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br. J. Pharmacol. 150, 5 17.
9. Benton R. L., Ross C. D. Miller K. E. (2000) Glutamine synthetase activities in spinal white and gray matter 7 days following spinal cord injury in rats. Neurosci. Lett. 291, 1 4.
10. Beschorner R., Simon P., Schauer N., Mittelbronn M., Schluesener H. J., Trautmann K., Dietz K. Meyermann R. (2007) Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia. Histopathology 50, 897 910.
11. Bushong E. A., Martone M. E. Ellisman M. H. (2004) Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development. Int. J. Dev. Neurosci. 22, 73 86.
12. Chang M. L., Wu C. H., Jiang-Shieh Y. F., Shieh J. Y. Wen C. Y. (2007) Reactive changes of retinal astrocytes and Muller glial cells in kainate-induced neuroexcitotoxicity. J. Anat. 210, 54 65.
13. Chen Y. Swanson R. A. (2003) Astrocytes and brain injury. J. Cereb. Blood Flow Metab. 23, 137 149.
14. Di Giorgi Gerevini V. D., Caruso A., Cappuccio I., Ricci V. L., Romeo S., Della R. C., Gradini R., Melchiorri D. Nicoletti F. (2004) The mGlu5 metabotropic glutamate receptor is expressed in zones of active neurogenesis of the embryonic and postnatal brain. Brain Res. Dev. Brain Res. 150, 17 22.
15. Domercq M., Etxebarria E., Perez-Samartin A. Matute C. (2005) Excitotoxic oligodendrocyte death and axonal damage induced by glutamate transporter inhibition. Glia 52, 36 46.
16. Eliasson C., Sahlgren C., Berthold C. H., Stakeberg J., Celis J. E., Betsholtz C., Eriksson J. E. Pekny M. (1999) Intermediate filament protein partnership in astrocytes. J. Biol. Chem. 274, 23996 24006.
17. Eng L. F., Ghirnikar R. S. Lee Y. L. (2000) Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 25, 1439 1451.
18. Ferraguti F., Corti C., Valerio E., Mion S. Xuereb J. (2001) Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Exp. Brain Res. 137, 1 11.
19. Gegelashvili G., Danbolt N. C. Schousboe A. (1997) Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J. Neurochem. 69, 2612 2615.
20. Gomes-Leal W., Corkill D. J., Freire M. A., Picanco-Diniz C. W. Perry V. H. (2004) Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury. Exp. Neurol. 190, 456 467.
21. Goursaud S., Maloteaux J. M. Hermans E. (2008) Activation of VIP/PACAP type 2 receptor by the peptide histidine isoleucine in astrocytes influences GLAST-mediated glutamate uptake. J. Neurochem. 105, 1165 1175.
22. Hertz L. Zielke H. R. (2004) Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci. 27, 735 743.
23. +-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1. J. Membr. Biol. 182, 17 30.
24. Korzhevskii D. E., Lentsman M. V., Gilyarov A. V., Kirik O. V. Vlasov T. D. (2008) Induction of nestin synthesis in rat brain cells by ischemic damage. Neurosci. Behav. Physiol. 38, 139 143.
25. Kozlova E. N. Takenaga K. (2005) A procedure for culturing astrocytes from white matter and the application of the siRNA technique for silencing the expression of their specific marker, S100A4. Brain Res. Brain Res. Protoc. 15, 59 65.
26. Krum J. M., Phillips T. M. Rosenstein J. M. (2002) Changes in astroglial GLT-1 expression after neural transplantation or stab wounds. Exp. Neurol. 174, 137 149.
27. Kukley M., Capetillo-Zarate E. Dietrich D. (2007) Vesicular glutamate release from axons in white matter. Nat. Neurosci. 10, 311 320.
28. Liedtke W., Edelmann W., Bieri P. L., Chiu F. C., Cowan N. J., Kucherlapati R. Raine C. S. (1996) GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 17, 607 615.
29. Maragakis N. J., Dietrich J., Wong V., Xue H., Mayer-Proschel M., Rao M. S. Rothstein J. D. (2004) Glutamate transporter expression and function in human glial progenitors. Glia 45, 133 143.
30. Matute C., Alberdi E., Domercq M., Sanchez-Gomez M. V., Perez-Samartin A., Rodriguez-Antiguedad A. Perez-Cerda F. (2007) Excitotoxic damage to white matter. J. Anat. 210, 693 702.
31. Miller R. H. Raff M. C. (1984) Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct. J. Neurosci. 4, 585 592.
32. Miller R. H., Abney E. R., Davis S., Ffrench-Constant C., Lindsay R., Patel R., Stone J. Raff M. C. (1986) Is reactive gliosis a property of a distinct subpopulation of astrocytes? J. Neurosci. 6, 22 29.
33. Pekny M. Nilsson M. (2005) Astrocyte activation and reactive gliosis. Glia 50, 427 434.
34. Raff M. C., Abney E. R., Cohen J., Lindsay R. Noble M. (1983) Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics. J. Neurosci. 3, 1289 1300.
35. Stanimirovic D. B., Ball R., Small D. L. Muruganandam A. (1999) Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. Int. J. Dev. Neurosci. 17, 173 184.
36. Sullivan S. M., Lee A., Bjorkman S. T., Miller S. M., Sullivan R. K., Poronnik P., Colditz P. B. Pow D. V. (2007) Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP. J. Biol. Chem. 282, 29414 29423.
37. Swanson R. A., Liu J., Miller J. W., Rothstein J. D., Farrell K., Stein B. A. Longuemare M. C. (1997) Neuronal regulation of glutamate transporter subtype expression in astrocytes. J. Neurosci. 17, 932 940.
38. Tamagno I. Schiffer D. (2006) Nestin expression in reactive astrocytes of human pathology. J. Neurooncol. 80, 227 233.
39. Tawfik V. L., Regan M. R., Haenggeli C., Lacroix-Fralish M. L., Nutile-McMenemy N., Perez N., Rothstein J. D. DeLeo J. A. (2008) Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience 152, 1086 1092.
40. Vermeiren C., Najimi M., Maloteaux J. M. Hermans E. (2005a) Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation. Neurochem. Int. 46, 137 147.
41. Vermeiren C., Najimi M., Vanhoutte N., Tilleux S., de Hemptinne I., Maloteaux J. M. Hermans E. (2005b) Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes. J. Neurochem. 94, 405 416.
42. Vermeiren C., de Hemptinne I., Vanhoutte N., Tilleux S., Maloteaux J. M. Hermans E. (2006) Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. J. Neurochem. 96, 719 731.
43. Wilhelmsson U., Bushong E. A., Price D. L., Smarr B. L., Phung V., Terada M., Ellisman M. H. Pekny M. (2006) Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc. Natl Acad. Sci. USA 103, 17513 17518.
44. Yarowsky P. J. Krueger B. K. (1989) Development of saxitoxin-sensitive and insensitive sodium channels in cultured neonatal rat astrocytes. J. Neurosci. 9, 1055 1061.
45. Ziskin J. L., Nishiyama A., Rubio M., Fukaya M. Bergles D. E. (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat. Neurosci. 10, 321 330.