Psoriasis and streptococci: The natural selection of psoriasis revisited

British Journal of Dermatology

Volumn 160, Issue 5, 2009, Pages 929-937

  McFadden, J P ^a   Baker, B S ^b   Powles, A V ^c   Fry, L ^c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

5 1 integrin; Bacterial internalization; Epidemic; Psoriasis; Scarlet fever; Th17 cells; Transforming growth factor

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL TOXIN; CYTOKINE; ERYTHROGENIC TOXIN; FIBRONECTIN; LIPOTEICHOIC ACID; M PROTEIN; PENICILLIN G; PEPTIDOGLYCAN; SUPERANTIGEN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

BACTEREMIA; BACTERICIDAL ACTIVITY; BETA HEMOLYTIC STREPTOCOCCUS; CHRONIC PLAQUE PSORIASIS; COXSACKIE VIRUS; DISEASE COURSE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; EPIDEMIC; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; GENE REGULATORY NETWORK; GENETIC LINKAGE; GENETIC VARIABILITY; HELICOBACTER PYLORI; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; IMMUNOLOGICAL PARAMETERS; INCIDENCE; INNATE IMMUNITY; INTERNALIZATION; INTRACELLULAR BACTERIUM; MICROORGANISM; MORTALITY; MUCOSA CELL; NONHUMAN; PATHOGENESIS; PHARYNGITIS; PHENOTYPIC VARIATION; PREVALENCE; PRIORITY JOURNAL; PSORIASIS; PSORIASIS VULGARIS; RECURRENT INFECTION; REGULATORY MECHANISM; REVIEW; RISK FACTOR; SCARLET FEVER; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS INFECTION; T LYMPHOCYTE; TH17 CELL; THROAT CULTURE; TONSILLITIS; TREATMENT DURATION; YERSINIA;

DISEASE OUTBREAKS; HUMANS; PSORIASIS; SELECTION (GENETICS); STREPTOCOCCAL INFECTIONS; TH1 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 64849108649     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09102.x     Document Type: Review

References (116)

1. McFadden JP. Hypothesis - the natural selection of psoriasis. Clin Exp Dermatol 1990 15 : 39 43.
2. Stern RS. Epidemiology of psoriasis. Dermatol Clin 1995 13 : 717 22.
3. Christophers E. Psoriasis - epidemiology and clinical spectrum. Clin Exp Dermatol 2001 26 : 314 20.
4. Langley RGB, Krueger GG, Griffiths CEM. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis 2005 64 (Suppl. 2 18 23.
5. Schafer T. Epidemiology of psoriasis. Dermatology 2006 212 : 327 37.
6. Gudjonsson JE, Elder JT. Psoriasis: epidemiology. Clin Dermatol 2007 25 : 535 46.
7. Morris A, Rogers M, Fischer G, Williams K. Childhood psoriasis: a clinical review of 1262 cases. Pediatr Dermatol 2001 18 : 188 98.
8. Anon. Medical notes, epidemiology section. Br Med J 1950 62 : 853 4.
9. Mouillac. Epidemiology of scarlet fever. Bull Soc Pathol Exot 1923 16 : 760 7.
10. Yip SY. The prevalence of psoriasis in the mongoloid race. J Am Acad Dermatol 1984 10 : 965 8.
11. League of Nations. Epidemiological Report of the Health Section 1929 8 : 245-76, 303-31.
12. Kerdal-Vegas F. Psoriasis in South America: geographical and racial factors. In : Psoriasis: Proceedings of the International Symposium on Psoriasis (Farber EM, Cox AJ, eds). Stanford, CA : Stanford University Press, 1971 35 9.
13. Heinbecker P, Irvine-Jones EIM. Susceptibility of Eskimos to the common cold and a study of their natural immunity to diphtheria, scarlet fever and bacterial infiltrates. J Immunol 1928 15 : 395 408.
14. Parry WE. Journal of a Second Voyage. London : J. Murray (Admiralty), 1824 546.
15. Harvald B. Genetic epidemiology of Greenland. Clin Genet 1989 36 : 364 7.
16. Roberts-Thompson PJ, Roberts-Thompson RA, Nikoloutsopoulos T, Gillis D. Immune dysfunction in Australian Aborigines. Asian Pac J Allergy Immunol 2005 23 : 235 44.
17. Lewis MJ. The People's Health: Public Health in Australia, 1788-1950. London : Greenwood Publishing Group, 2003 25 6.
18. Kenney J. Psoriasis in the American black. In : Psoriasis: Proceedings of the International Symposium on Psoriasis (Farber EM, Cox AJ, eds). Stanford, CA : Stanford University Press, 1971 49 52.
19. Simons R. Additional studies on psoriasis in the tropics and in starvation camps. J Invest Dermatol 1949 12 : 285 94.
20. Smits E. The immunity of the Javanese to scarlet fever: the Dick reaction. Geneeskd Tijdschr voor Nederl-indie 1927 67 : 651 7.
21. Bos JD. Psoriasis, innate immunity and gene pools. J Am Acad Dermatol 2007 56 : 468 71.
22. Marrack P, Kappler J. The staphylococcal enterotoxins and their relatives. Science 1990 248 : 705 11.
23. Proft T, Fraser JD. Bacterial superantigens. Clin Exp Immunol 2003 133 : 299 306.
24. Faulkner L, Cooper A, Fabtino C et al. The mechanisms of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. J Immunol 2005 175 : 6870 7.
25. Zollner TM, Nuber V, Duijvestin AM et al. Superantigens but not mitogens are capable of inducing upregulation of E-selectin ligands on human T lymphocytes. Exp Dermatol 1997 6 : 161 6.
26. Reddy M, Davis C, Wong J, Prabhakar U. Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (beta 1 and beta 2), IL-2Ralpha, and CXCR3. Cell Immunol 2005 236 : 131 9.
27. Tervaert WCC, Essevald H. A study of the incidence of haemolytic streptococci in the throat in patients with psoriasis vulgaris, with reference to their role in the pathogenesis of this disease. Dermatologica 1970 148 : 282 90.
28. Norrlind R. The significance of infections in the origination of psoriasis. Acta Rheumatol Scand 1954 1 : 135 44.
29. Whyte HJ, Baughman RD. Acute guttate psoriasis and streptococcal infection. Arch Dermatol 1964 89 : 350 6.
30. Leung DY, Travers JB, Giorno R et al. Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. J Clin Invest 1995 96 : 2106 12.
31. Davison SC, Allen MH, Mallon E, Barker JN. Contrasting patterns of streptococcal superantigen-induced T-cell proliferation in guttate versus chronic plaque psoriasis. Br J Dermatol 2001 145 : 245 51.
32. Boneca IG. The role of peptidoglycans in pathogenesis. Curr Opin Microbiol 2005 8 : 46 53.
33. Liu C, Xu Z, Gupta D, Dziarski R. Peptidoglycan recognition proteins. A novel family of four innate immunity pattern recognition molecules. J Biol Chem 2001 276 : 34686 94.
34. Cho HJ, Fraser IP, Fukawe K et al. Human peptidoglycan recognition protein S is an effector of neutrophil mediated innate immunity. Blood 2005 106 : 2551 6.
35. Kengatharan KM, De Kimpe S, Robson C et al. Mechanisms of Gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock and multiple organ failure. J Exp Med 1998 188 : 305 15.
36. Wray GM, Foster SJ, Hinds CJ, Thiemermann CA. Cell wall component from pathogenic and non-pathogenic Gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause release of TNF-alpha, nitric oxide production, shock and multiple organ injury in the rat. Shock 2001 15 : 135 42.
37. Pahlman LI, Morgelin M, Eckert J et al. Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol 2006 177 : 1221 8.
38. Hopkins PA, Fraser JD, Pridmore AC et al. Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. Blood 2005 105 : 3655 62.
39. Schwab JH, Brown RR, Anderle SK, Schlievert PM. Superantigen can reactivate bacterial cell wall-induced arthritis. J Immunol 1993 150 : 4151 9.
40. Mansson A, Adner M, Cardell LQ. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res 2006 7 : 36 7.
41. Komorowska A, Komorowski J, Babasik M et al. Cytokines locally produced from the hypertrophic nasopharyngeal and palatine tonsils. Int J Pediatr Otorhinolaryngol 2005 69 : 937 41.
42. Ball SL, Siou GP, Wilson JA et al. Expression and immunolocalisation of antimicrobial peptides within human palatine tonsils. J Laryngol Otol 2007 121 : 973 8.
43. Medina E, Lengeling A. Genetic regulation of host responses to group A streptococcus in mice. Brief Funct Genomic Proteomic 2005 4 : 248 57.
44. Valdimarsson H, Baker BS, Jonsdottir I et al. Psoriasis - a T-cell-mediated autoimmune disease induced by streptococcal superantigens? Immunol Today 1996 17 : 46 7.
45. Johnston A, Gudjonsson JE, Sigmunsdottir H et al. Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M protein are largely restricted to skin-homing CD8(+) T cells. Clin Exp Immunol 2004 138 : 83 93.
46. Fry L, Baker BS, Powles AV. Psoriasis - a possible candidate for vaccination. Clin Dev Immunol 2006 13 : 361 7.
47. Gaspari AA. Innate and adaptive immunity and the pathophysiology of psoriasis. J Am Acad Dermatol 2006 54 (Suppl. 2 S67 80.
48. Griffiths CEM, Barker JNWN. Pathogenesis and clinical features of psoriasis. Lancet 2007 370 : 263 71.
49. Baker BS, Ovigne JM, Powles AV et al. Normal keratinocytes express toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 2003 148 : 670 9.
50. Leonardi CL, Powers JL, Matheson RT et al. Etanercerpt as monotherapy in patients with psoriasis. N Engl J Med 2003 349 : 2014 22.
51. Liu L, Krueger JG, Bowcock AM. Psoriasis: genetic associations and immune system changes. Genes Immun 2007 8 : 1 12.
52. Hull MW, Chow AW. Indigenous microflora and innate immunity of the head and neck. Infect Dis Clin North Am 2007 21 : 265 82.
53. Lesmeister MJ, Bothwell MR, Misfeldt ML. Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palatine tonsils: a preliminary report. Int J Pediatr Otorhinolaryngol 2006 70 : 987 92.
54. Fitch E, Harper E, Skorcheva I et al. Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep 2007 9 : 461 7.
55. Wardrop P, Weller R, Marais J, Kavanagh G. Tonsillitis and chronic psoriasis. Clin Otolaryngol 1998 23 : 67 8.
56. Gudjonsson JE, Thorarinsson AM, Sigurgeirsson B et al. Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study. Br J Dermatol 2003 149 : 530 4.
57. Rantakokko K, Rimpilainen M, Uksila J et al. Antibodies to streptococcal cell wall in psoriatic arthritis and psoriasis. Clin Exp Rheumatol 1997 15 : 399 404.
58. El-Rachkidy RG, Hales JM, Freestone PP et al. Increased blood levels of IgG reactive with secreted Streptococcus pyogenes proteins in chronic plaque psoriasis. J Invest Dermatol 2007 127 : 1337 42.
59. Rosenberg EW, Noah PW, Zanolli MD et al. Use of rifampicin with penicillin and erythromycin in the treatment of psoriasis. J Am Acad Dermatol 1986 14 : 761 4.
60. Nyfors A, Rasmussen PA, Lemholt K, Eriksen B. Improvement of recalcitrant psoriasis vulgaris after tonsillectomy. J Laryngol Otol 1976 90 : 789 94.
61. Baker BS, Powles AV, Fry L. Peptidoglycan: a major aetiological factor for psoriasis. Trends Immunol 2006 27 : 545 51.
62. Owen CM, Chalmers RJ, O'Sullivan T, Griffiths CEM. Antistreptococcal interventions for guttate and chronic plaque psoriasis. Cochrane Database Syst Rev 2000 2 : CD001976.
63. Saxena VN, Dogra J. Long-term use of penicillin for the treatment of chronic plaque psoriasis. Eur J Dermatol 2005 15 : 259 62.
64. Osterlund A, Popa R, Nikkila T et al. Intracellular reservoir of Streptococcus pyogenes in vivo: a possible explanation for recurrent pharyngotonsillitis. Laryngoscope 1997 107 : 640 7.
65. Osterlund A, Engstrand L. An intracellular sanctuary for Streptococcus pyogenes in human tonsillar epithelium - studies of asymptomatic carriers and in vitro cultured biopsies. Acta Otolaryngol 1997 117 : 883 8.
66. Nitsche-Schmitz DP, Rohde M, Chatwal GS. Invasion mechanisms of Gram-positive pathogenic cocci. Thromb Haemost 2007 98 : 488 96.
67. Cue D, Southern SO, Southern PJ et al. A nonpeptide integrin antagonist can inhibit cell ingestion of Streptococcus pyogenes by blocking formation of integrin alpha 5 beta 1-fibronectin-M1 protein complexes. Proc Natl Acad Sci USA 2000 97 : 2858 63.
68. Weston BS, Wahab NA, Mason RM. CTFG mediates TGF-beta-induced fibronectin deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol 2003 14 : 601 10.
69. Wang B, Li S, Southern PJ, Cleary PP. Streptococcal modulation of cellular invasion via TGF-beta1 signalling. Proc Natl Acad Sci USA 2006 103 : 2380 5.
70. Norrby-Teglund A, Pauksens K, Norgren M, Holm SE. Correlation between serum TNF alpha and IL6 levels and severity of group A streptococcal infections. Scand J Infect Dis 1995 27 : 125 30.
71. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the TH17 lineage. Nature 2006 441 : 231 4.
72. Veldhoen M, Hocking RJ, Atkins CJ et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17 producing T cells. Immunity 2006 24 : 179 89.
73. Sutton C, Brereton C, Keogh B et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006 203 : 1685 91.
74. Strait RT, Ruddy RM, Friedland LR et al. A pilot study of the predictive value of plasma tumor necrosis factor alpha and interleukin 1 beta for Streptococcus pneumoniae bacteremia in febrile children. Acad Emerg Med 1997 4 : 44 51.
75. Aujla SJ, Dubin PJ, Kolls JK. Th17 cells and mucosal defense. Semin Immunol 2007 19 : 377 82.
76. Kao CY, Chen Y, Thai P et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signalling pathways. J Immunol 2004 173 : 3482 91.
77. Korn T, Oukka M, Kuchroo V, Bettelli E. Th 17 cells: effector T cells with inflammatory properties. Semin Immunol 2007 19 : 362 71.
78. Hoshino H, Laan M, Sjostrand M et al. Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol 2000 105 : 143 9.
79. Ye P, Rodriguez FH, Kanaly S et al. Requirement of interleukin 17 receptor signalling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defence. J Exp Med 2001 194 : 519 28.
80. Urban CF, Lourido S, Zychlinsky A. How do microbes evade neutrophil killing? Cell Microbiol 2006 8 : 1687 96.
81. Heng MCY, Kloss SG, Kuehn CS, Chase DG. Significance and pathogenesis of basal keratinocyte herniations in psoriasis. J Invest Dermatol 1986 87 : 362 6.
82. Bata-Csorgo Z, Cooper KD, Ting KM et al. Fibronectin and alpha5 integrin regulate keratinocyte cell cycling. J Clin Invest 1998 101 : 1509 18.
83. Fryand O. Studies on fibronectin in the skin II. Indirect immunofluorescence studies in psoriasis vulgaris. Arch Dermatol Res 1979 266 : 33 41.
84. Symington BE. Growth signalling through the alpha5 beta1 fibronectin receptor. Biochem Biophys Res Commun 1995 208 : 126 34.
85. Pellegrini G, De Luca M, Orecchia G et al. Expression, topography and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin. J Clin Invest 1992 89 : 1783 95.
86. Carroll JM, Rosario RM, Watt FM. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell 1995 83 : 957 68.
87. Flisiak I, Chodynicka B, Porebski P, Flisiak R. Association between psoriasis severity and transforming growth factor beta (1) and beta (2) in plasma and scales from psoriasis lesions. Cytokine 2002 19 : 121 5.
88. Baran W, Szepietowski JC, Mazur G, Baran E. TGF-beta(1) gene polymorphisms in psoriasis vulgaris. Cytokine 2007 38 : 8 11.
89. Li AG, Wang D, Feng XH, Wang XJ. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 2004 23 : 1770 81.
90. Serini G, Valdembri D, Bussolini F. Integrins and angiogenesis: a sticky business. Exp Cell Res 2006 312 : 651 8.
91. Nestle FO, Gillet M. Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alpha. J Invest Dermatol 2005 125 : xiv xv.
92. Lew W, Bowcock AM, Krueger JG. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and 'type 1' inflammatory gene expression. Trends Immunol 2004 25 : 295 305.
93. Tenaud I, Leroy S, Chebassier N, Dreno B. Modulation in vitro of keratinocyte integrins by interferon-alpha and interferon-gamma. Int J Dermatol 2002 41 : 836 40.
94. Kawashima A, Kawahara E, Tokuda R, Nakanishi I. Tumour necrosis factor provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in osteosarcoma cells. Cell Biol Int 2001 25 : 319 29.
95. Pene J, Chevalier S, Preisser L et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008 180 : 7423 30.
96. Nair R, Ruether A, Stuart PE, Jenisch S. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 2008 128 : 1653 61.
97. Wolk K, Witte E, Wallace E et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006 36 : 1309 23.
98. Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th 17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006 203 : 2271 9.
99. Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th 17 cells in human disease. Immunol Rev 2008 223 : 87 113.
100. Blauvelt A. T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis. J Invest Dermatol 2008 128 : 1064 7.
101. Fry L, Baker BS. Triggering psoriasis: the role of infections and medications. Clin Dermatol 2007 25 : 606 15.
102. Pouessel G, Ythier H, Carpentier O et al. Childhood pustular psoriasis associated with Panton-Valentine leukocidin-producing Staphylococcus aureus. Pediatr Dermatol 2007 24 : 401 4.
103. Qayoom S, Ahmad QM. Psoriasis and Helicobacter pylori. Indian J Dermatol Venereol Leprol 2003 69 : 133 4.
104. Korshova TP, Shyrobokov VP, Koliandenko VH et al. Coxsackie B viral infection in the aetiology and clinical pathogenesis of psoriasis. Lik Sprava 2001 3 : 54 8.
105. Lapadula G, Iannone F, Covelli M et al. Anti-enterobacteria antibodies in psoriatic arthritis. Clin Exp Rheumatol 1992 10 : 461 6.
106. Barillari G, Sgadari C, Fiorelli V et al. The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. Blood 1999 94 : 663 72.
107. Kintarak S, Whawell SA, Speight PM et al. Internalization of Staphylococcus aureus by human keratinocytes. Infect Immun 2004 72 : 5668 75.
108. Su B, Johansson S, Fallman M et al. Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells. Gastroenterology 1999 117 : 595 604.
109. Uchio E, Kimura R, Huang YH. Antiadenoviral effect of the alpha 5 beta 1 integrin receptor ligand GRGDSP peptide, in serotypes that cause acute keratoconjuctivitis. Ophthalmologica 2007 221 : 326 30.
110. Klotz SA, Pendrak ML, Hein RC. Antibodies to alpha 5 beta 1 and alpha (v) beta 3 integrins react with Candida albicans alcohol dehydrogenase. Microbiology 2001 147 : 3159 64.
111. Scibelli A, Matteoli G, Roperto S et al. Flavoridin inhibits Yersinia enterocolitica uptake into fibronectin-adherent HeLA cells. FEMS Microbiol Lett 2005 247 : 51 7.
112. Higgins EM, du Vivier AW. Cutaneous disease and alcohol misuse. Br Med Bull 1994 50 : 85 98.
113. Wang JH, Batey RG, George J. Role of ethanol in the regulation of hepatic stellate cell function. World J Gastroenterol 2006 12 : 6926 32.
114. Farkas A, Kemeny L, Szeil M et al. Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis. Arch Dermatol Res 2003 295 : 56 62.
115. Wang XJ, Han G, Owens P et al. Role of TGF beta-mediated inflammation in cutaneous wound healing. J Investig Dermatol Symp Proc 2006 11 : 112 17.
116. Duncan CJ, Duncan SR, Scott S. The dynamics of scarlet fever epidemics in England and Wales in the 19th century. Epidemiol Infect 1995 117 : 493 9.