A nonpeptide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin α5β1-fibronectin-M1 protein complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 6, 2000, Pages 2858-2863

  Cue, David ^a   Southern, Sarka O ^a   Southern, Peter J ^a   Prabhakar, Jadhar ^b   Lorelli, William ^b   Smallheer, Joanne M ^b   Mousa, Shaker A ^b   Patrick Cleary, P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BINDING PROTEIN; FIBRONECTIN; INTEGRIN; INTEGRIN ANTAGONIST; PROTEIN M1; SJ 755; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES; TONSIL CELL;

ADHESINS, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BENZIMIDAZOLES; CARRIER PROTEINS; CELL ADHESION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FIBRONECTINS; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; PEPTIDES; PROTEIN BINDING; RECEPTORS, FIBRONECTIN; SPIRO COMPOUNDS; STREPTOCOCCUS PYOGENES; TONSIL;

BACTERIA (MICROORGANISMS); MAMMALIA; STREPTOCOCCUS PYOGENES;

EID: 0034646204     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.050587897     Document Type: Article

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