A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-α, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat

Shock

Volumn 15, Issue 2, 2001, Pages 135-142

  Wray, Gillian M ^a   Foster, Simon J ^b   Hinds, Charles J ^a   Thiemermann, Christoph ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Infection; Lipopolysaccharide; Nitric oxide; Organ dysfunction; Organ injury; Sepsis; Shock; Systemic inflammatory response syndrome; Tumour necrosis factor

Indexed keywords

LIPOPOLYSACCHARIDE; NITRATE; NITRIC OXIDE; NITRITE; PEPTIDOGLYCAN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BACILLUS SUBTILIS; BLOOD; BLOOD PRESSURE; CELL WALL; CHEMISTRY; DOSE RESPONSE; DRUG POTENTIATION; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; KIDNEY; LIVER; MALE; METABOLISM; MICROBIOLOGY; MULTIPLE ORGAN FAILURE; PANCREAS; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SEPTIC SHOCK; STAPHYLOCOCCUS AUREUS; WISTAR RAT;

ANIMALS; BACILLUS SUBTILIS; BLOOD PRESSURE; CELL WALL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; KIDNEY; LIPOPOLYSACCHARIDES; LIVER; MALE; MULTIPLE ORGAN FAILURE; NITRATES; NITRIC OXIDE; NITRITES; PANCREAS; PEPTIDOGLYCAN; RATS; RATS, WISTAR; SHOCK, SEPTIC; STAPHYLOCOCCUS AUREUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035261454     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200115020-00010     Document Type: Article

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