Role of serotonin in gastrointestinal motility and irritable bowel syndrome

Clinica Chimica Acta

Volumn 403, Issue 1-2, 2009, Pages 47-55

  Sikander, Arbab ^a   Rana, Satya Vati ^a   Prasad, Kaushal Kishor ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Diarrhea; Functional bowel disorder; Gut; Irritable bowel syndrome; Serotonin; Serotonin transporter

Indexed keywords

ALOSETRON; AMITRIPTYLINE; ANTIDIARRHEAL AGENT; ATI 7505; CISAPRIDE; DOXEPIN; FLUOXETINE; IMIPRAMINE; ONDANSETRON; PAROXETINE; PLACEBO; PRUCALOPRIDE; PUMOSETRAG; SEROTONIN; SEROTONIN 4 AGONIST; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SUMATRIPTAN; TEGASEROD; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ARTICLE; CARDIOTOXICITY; CLINICAL TRIAL; CONSTIPATION; DEPRESSION; DIARRHEA; DRUG RECEPTOR BINDING; DRUG TARGETING; EXCITATORY POSTSYNAPTIC POTENTIAL; GASTROINTESTINAL MOTILITY; GENETIC POLYMORPHISM; HEART INFARCTION; HUMAN; INTESTINE INNERVATION; IRRITABLE COLON; ISCHEMIA; ISCHEMIC COLITIS; KNOCKOUT GENE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTONIN METABOLISM; SEROTONIN RELEASE; STROKE; TREATMENT OUTCOME; UNSTABLE ANGINA PECTORIS;

ANIMALS; GASTROINTESTINAL MOTILITY; HUMANS; IRRITABLE BOWEL SYNDROME; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 64849088421     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.01.028     Document Type: Article

References (117)

1. Tyce G.M. Biochemistry of serotonin. In: Vanhoutte P.M. (Ed). Serotonin and the cardiovascular system (1985), Raven Press, New York 1-13
2. Gershon M.D., Drakontides A.B., and Ross L.L. Serotonin: synthesis and release from the myenteric plexus of the mouse intestine. Science 149 (1965) 197-199
3. Yu P.L., Fujimura M., Okumiya K., Kinoshita M., Hasegawa H., and Fujimiya M. Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts. J Comp Neurol 411 (1999) 654-665
4. Gershon M.D., and Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132 (2007) 397-414
5. Walther D.J., Peter J.U., Bashammakh S., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76-80
6. Cote F., Thevenot E., Fligny C., et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci USA 100 (2003) 13525-13530
7. Tamir H., Payette R.F., Huang Y.L., Liu K.P., and Gershon M.D. Human serotonectin: a blood glycoprotein that binds serotonin and is associated with platelets and white blood cells. J Cell Sci 73 (1985) 187-206
8. Wade P.R., Chen J., Jaffe B., Kassem I.S., Blakely R.D., and Gershon M.D. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci 16 (1996) 2352-2364
9. Gershon M.D. Review article: Roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 13 (1999) 15-30
10. Wade P.R., Tamir H., Kirchgessner A.L., and Gershon M.D. Analysis of the role of 5-HT in the enteric nervous system using anti-idiotypic antibodies to 5-HT receptors. Am J Physiol 266 (1994) G403-G416
11. Zhou X., and Galligan J.J. Synaptic activation and properties of 5-hydroxytryptamine (3) receptors in myenteric neurons of guinea pig intestine. J Pharmacol Exp Ther 290 (1999) 803-810
12. Gershon M.D., Mawe G.M., and Brachek T.A. 5-hydroxytryptamine and enteric neurons. In: Fozard J.R., ed. Peripheral actions of 5-hydroxytryptamine (serotonin). Pharmacol Ther 62 (1994) 159-173
13. Mawe G.M., and Gershon M.D. The 5-HT1P receptor. Drug News Persp 6 (1993) 24-30
14. Bülbring E., and Gershon M.D. 5-Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach. J Physiol 192 (1967) 823-846
15. Bulbring E., and Crema A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol (Lond) 146 (1959) 18-28
16. Bulbring E., and Crema A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol 13 (1958) 4-57
17. Sugiuar T., Bielefeldt K., and Gebhart G.F. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci 24 (2004) 9521-9530
18. Grundy D., Blackshaw L.A., and Hillsley K. Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Dig Dis Sci 39 Suppl 12 (1994) S44-S47
19. Kirchgessner A.L., Liu M.T., and Gershon M.D. In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes. J Comp Neurol 371 (1996) 270-286
20. Pan H., and Gershon M.D. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J Neurosci 20 (2000) 3295-3309
21. Cooke H.J., Sidhu M., and Wang Y.Z. 5-HT activates neural reflexes regulating secretion in the guinea-pig colon. Neurogastroenterol Motil 9 (1997) 181-186
22. Kim M., Cooke H.J., Javed N.H., Carey H.V., Christofi F., and Raybould H.E. D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology 121 (2001) 1400-1406
23. Bertrand PP, Furness JB and Bornstein JC. 5-HT and ATP stimulate the mucosal terminals of some myenteric sensory neurons and cause increases in excitability in a population of sensory neurons. Falk Symposium No. 112. Neurogastroenterology - from the basics to the clinics (1999) Freiburg, Germany.
24. Gershon M.D. Review article: serotonin receptors and transporters-roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 20 Suppl 7 (2004) 3-14
25. Chen J.X., Pan H., Rothman T.P., Wade P.R., and Gershon M.D. Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am J Physiol 275 (1998) G433-G448
26. Coote J.H., and MacLeod V.H. The influence of bulbospinal monoaminergic pathways on sympathetic nerve activity. J Physiol (Lond) 241 (1974) 453-475
27. Richardson B.P., Engel G., Donatsch P., and Stadler P.A. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316 (1985) 126-131
28. Donowitz M., Charney A.N., and Hefferman J.M. Effect of serotonin treatment on intestinal transport in the rabbit. Am J Physiol 232 (1977) 85-94
29. Siriwardena A., and Kellum J.M. A 5-HT receptor mediates serotonin-induced electrolyte transport in rat left colon. J Surg Res 55 (1993) 323-329
30. Nilsson O., Cassuto J., Larsson P.A., et al. 5-Hydroxytryptamine and cholera secretion: a histochemical and physiological study in cat. Gut 24 (1983) 542-548
31. Lundgren O. 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion. Gastroenterology 115 (1998) 1009-1012
32. Peregrin A.T., Ahlman H., Jodal M., and Lundgren O. Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br J Pharmacol 127 (1999) 887-894
33. Sjoqvist A., Cassuto J., Jodal M., and Lundgren O. Actions of serotonin antagonists on cholera-toxin-induced intestinal fluid secretion. Acta Physiol Scand 145 (1992) 229-237
34. Peart W.S., and Robertson J.I.S. The effect of a serotonin antagonist (UML 491) in carcinoid disease. Lancet ii (1961) 1172-1174
35. Gustafsen J., Lendorf A., Raskov H., and Boesby S. Ketanserin versus placebo in carcinoid syndrome. A clinical controlled trial. Scand J Gastroenterol 21 (1986) 816-818
36. Anderson J.V., Coupe M.O., Morris J.A., Hodgson H.J., and Bloom S.R. Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist. Br Med J 294 (1987) 1129-1135
37. Bearcroft C.P., Perrett D., and Farthing M.J.G. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 42 (1998) 42-46
38. Houghton L.A., Atkinson W., Whitaker R.P., Whorwell P.J., and Rimmer M.J. Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Gut 52 (2003) 663-670
39. Dunlop S.P., Coleman N.S., Blackshaw P.E., et al. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 3 (2005) 349-357
40. Atkinson W., Lockhart S., Whorwell P.J., Keevil B., and Houghton L.A. Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome. Gastroenterology 130 (2006) 34-43
41. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
42. Airaksinen M.M., Miettinen T.A., and Huttunen J. Glucuronidation of 5-hydroxyindole derivatives in vitro. Biochem Pharmacol 14 (1965) 1019-1023
43. Tonini M., and De Ponti F. Serotonin modulation of gastrointestinal motility. In: Gaginella T.S., and Galligan J.J. (Eds). Serotonin and gastrointestinal function (1995), CRC Press, Boca Raton 53-84
44. Briejer M.R., Akkermans L.M., and Schuurkes J.A. Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility. Pharmacol Rev 47 (1995) 631-651
45. Read N.W., and Gwee K.A. The importance of 5-hydroxytryptamine receptors in the gut. Pharmacol Ther 62 (1994) 159-173
46. Galligan J.J. Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons. In: Gaginella T.S., and Galligan J.J. (Eds). Serotonin and gastrointestinal function (1995), CRC Press, Boca Raton 109-126
47. Prins N.H., Briejer M.R., Van Bergen P.J., Akkermans L.M.A., and Schuurkes J.A.J. Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle. Br J Pharmacol 128 (1999) 849-852
48. Dietrich C., and Kilbinger H. 5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms. Neuropharmacology 35 (1996) 483-488
49. Kuemmerle J.F., Murthy K.S., Grider J.R., Martin D., and Makhlouf G. Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells. Gastroenterology 109 (1995) 1791-1800
50. Derkach V., Suprenant A., and North R.A. 5-HT3 receptors are membrane ion channels. Nature 339 (1989) 706-709
51. Von der Ohe M.R., Hanson R.B., and Camilleri M. Serotonergic mediation of postprandial colonic tone and phasic responses in man. Gut 35 (1994) 536-541
52. Scolapio J.S., Camilleri M., von der Ohe M., and Hanson R.B. Ascending colon response to feeding: evidence for a 5-hydroxytryptamine-3 mechanism. Scand J Gastroenterol 30 (1995) 562-567
53. Von de Ohe M.R., Camilleri M., and Kvols L.K. A 5-HT antagonists corrects the postprandial colonic hypertonic response in carcinoid diarrhea. Gastroenterology 106 (1994) 1184-1189
54. Furness J.B., Kunze W.A.A., and Clerc N. Nutrient tasting and signaling mechanisms in the gut II. The intestine as a sensor organ: neural, endocrine, and immune response. Am J Physiol 277 (1999) G922-G928
55. Grider J.R., Kuemmerle J.F., and Jin J.G. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1P receptors on sensory CGRP neurons. Am J Physiol 270 (1996) G778-G782
56. Kadowaki M., Wade P.R., and Gershon M.D. Participation of 5-HT4 and nicotinic receptors in the peristaltic reflex of guinea pig distal colon. Am J Physiol 271 (1996) G849-G857
57. Gershon M.D., and Liu M.T. Serotonin and neuroprotection in functional bowel disorders. Neurogastroenterol Motil 19 Suppl. 2 (2007) 19-24
58. Tuladhar B.R., Costall B., and Naylor R.J. 5-HT3 and 5-HT4 receptor-mediated facilitation of the emptying phase of the peristaltic reflex in the marmoset isolated ileum. Br J Pharmacol 117 (1996) 1679-1684
59. Tuladhar B.R., Kaisar M., and Naylor R.J. Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum. Br J Pharmacol 122 (1997) 1174-1178
60. Burks T.F. Neurotransmission and neurotransmitters. In: Johnson L.R. (Ed). Physiology of the gastrointestinal tract. 3rd ed. (1994), Raven Press, New York 211-242
61. Blakely R.D., Berson H.E., Fremeau R.T., et al. Cloning and expression of a functional serotonin transporter from rat brain. Nature 354 (1991) 66-70
62. Blakely R.D., Defelice L.J., and Galli A. Biogenic amine neurotransmitter transporters: just when you thought you knew them. Physiology (Bethesda) 20 (2005) 225-231
63. Chen J.J., Zhishan L., Pan H., et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter (SERT): abnormal intestinal motility and the expression of cation transporters. J Neurosci 21 (2001) 6348-6361
64. Coates M.D., Mahoney C.R., Linden D.R., et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126 (2004) 1657-1664
65. Da Prada M., Tranzer J.P., and Pletscher A. Storage of 5-hydroxytryptamine in human blood platelets. Experientia 28 (1972) 1328-1329
66. Gershon M.D., and Jonakait G.M. Uptake and release of 5-hydroxytryptamine by enteric 5-hydroxytryptaminergic neurones: effects of fluoxetine (Lilly 110140) and chlorimipramine. Br J Pharmacol 66 (1979) 7-9
67. Linden D.R., Chen J.X., Gershon M.D., Sharkey K.A., and Mawe G.M. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 285 (2003) G207-G216
68. Li Q., Wichems C., Heils A., Lesch K.P., and Murphy D.L. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. J Neurosci 20 (2000) 7888-7895
69. Li Q., Wichems C.H., Ma L., et al. Brain region specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J Neurochem 84 (2003) 1256-1265
70. Liu M.T., Rayport S., Jiang Y., Murphy D.L., and Gershon M.D. Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol 283 (2002) G1398-1411
71. Hahn B.A., Yan S., and Strassels S. Impact of irritable bowel syndrome on quality of life and resource use in the United States and United Kingdom. Digestion 60 (1999) 77-81
72. Ragnarsson G., and Bodemar G. Division of the irritable bowel syndrome into subgroups on the basis of daily recorded symptoms in two outpatients samples. Scand J Gastroenterol 34 (1999) 993-1000
73. Hammer J., and Talley N.J. Diagnostic criteria for the Irritable bowel syndrome. Am J Med 107 (1999) 5S-11S
74. Prior A., Maxton D.G., and Whorwell P.J. Anorectal manometry in irritable bowel syndrome: differences between diarrhea and constipation predominant subjects. Gut 31 (1990) 458-462
75. Moskwa A., Chojnacki J., Wiśiewska-Jarosińska M., et al. Serum serotonin concentration and urine 5-hydroxyindole acetic acid excretion in patients with irritable bowel syndrome. Pol Merkur Lekarski 22 131 (2007) 366-368
76. Sikander A., Rana S.V., Sinha S.K., Prasad K.K., Bhasin D.K., and Singh K. Altered serotonin signaling in IBD, diarrhea-predominant IBS and Microscopic colitis. Indian J Gastoenterol 26 Suppl. 2 (2007) A42
77. Dunlop S.P., Jenkins D., Neal K.R., and Spiller R.C. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in post infectious IBS. Gastroenterology 125 (2003) 1651-1659
78. Li Z.S., Zhan L.X., Zou D.W., Xu G.M., Man X.H., and Ye X.T. Morphological and functional alteration of serotonin-producing intestinal enterochromaff in cells in patients with irritable bowel syndrome. Zhonghua Xiaohua Zazhi 24 (2004) 94-97
79. Jiang M., Lin L.P., and Fu B.Y. Distribution feature of colonic 5-HT in irritable bowel syndrome. Shijie Huaren Xiaohua Zazhi 13 (2005) 541-543
80. Wang Z.J., Ouyang Q., Zou Y.G., Peng L., and Wang Y.F. Comparison of intestinal mucosal monamine neurotransmitter of ulcerative colitis and irritable bowel syndrome. Zhonghua Neike Zazhi 11 (2005) 851-852
81. El-Salhy M., Norrgard O., and Spinnell S. Abnormal colonic endocrine cells in patients with chronic idiopathic slow-transit constipation. Scand J Gastroenterol 34 (1999) 1007-1011
82. Zhao R., Baig M.K., Wexner S.D., et al. Enterochromaffin and serotonin cells are abnormal for patients with colonic inertia. Dis Colon Rectum 43 (2000) 858-863
83. Baig M.K., Zhao R.H., Woodhouse S.L., et al. Variability in serotonin and enterochromaffin cells in patients with colonic inertia and idiopathic diarrhoea as compared to normal controls. Colorectal Dis 4 (2002) 348-354
84. Spiller R.C., Jenkins D., Thornley J.P., et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47 (2000) 804-811
85. Bose M., Nickols C., Feakins R., and Farthing M.J.G. 5-Hydroxytryptamine and enterochromaffin cells in the irritable bowel syndrome. Gastroenterology 118 (2000) A563
86. Kyosola K., Penttila O., and Salaspuro M. Rectal mucosal adrenergic innervation and enterochromaffin cells in ulcerative colitis and irritable colon. Scand J Gastroenterol 12 (1977) 363-367
87. Miwa J., Echizen H., Matsueda K., and Umeda N. Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion 63 (2001) 188-194
88. Heils A., Teufel A., Petri S., et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 66 (1996) 2621-2624
89. Lesch K.P., Bengel D., Heils A., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
90. Stoltenberg S.F., Twitchell G.R., Hanna G.L., et al. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114 (2002) 230-234
91. Heitkemper M.M., Kohen R., Jarrett M.E., Cain K.C., Burr R.L., and Poppe A. Association of SERT polymorphism with psychological distress, symptoms and predominant stool group in women with irritable bowel syndrome. Gastroenterology 4 (2005) A59
92. Yeo A., Boyd P., Lumsden S., et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 53 (2004) 1452-1458
93. Pata C., Erdal M.E., Derici E., Yazar A., Kanik A., and Ulu O. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 97 (2002) 1780-1784
94. Li Y., Nie Y., Xie J., et al. The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci 52 (2007) 2942-2949
95. Wang B.M., Wang Y.M., Zhang W.M., et al. Serotonin transporter gene polymorphism in irritable bowel syndrome. Zhonghua Nei Ke Za Zhi 43 (2004) 439-441
96. Camilleri M., Atanasova E., Carlson P.J., et al. Serotonin-transporter polymorphism pharmacogenetics in diarrhea predominant irritable bowel syndrome. Gastroenterology 123 (2002) 425-432
97. Lee D.Y., Park H., Kim W.H., Lee S.I., Seo Y.J., and Choi Y.C. Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome. Korean J Gastroenterol 43 (2004) 18-22
98. Kim H.J., Camilleri M., Carlson P.J., et al. Association of distinct alpha (2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 53 (2004) 829-837
99. Park J.M., Choi M.G., Park J.A., et al. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil 18 (2006) 995-1000
100. Saito Y.A., Locke III G.R., Zimmerman J.M., et al. A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 19 (2007) 465-470
101. Niesler B., Fell C., Kapeller J., et al. SERT-P polymorphism in the serotonin transporter gene and irritable bowel syndrome: what's going on?. Gastroenterology 132 4 Suppl. 2 (2007) A675
102. Van Kerkhoven L.A.S., Laheij R.J.F., and Jansen J.B.M.J. Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome. Aliment Pharmacol Ther 26 (2007) 979-986
103. Bellini M., Rappelli L., Blandizzi C., et al. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron. Am J Gastroenterol 98 (2003) 2705-2711
104. Blakely R.D., and Bauman A.L. Biogenic amine transporters: regulation in flux. Curr Opin Neurobiol 10 (2000) 328-336
105. Costall B., and Naylor R.J. 5-HT3 receptors. Curr Drug Targets CNS Neurol Disord 3 (2004) 27-37
106. Bockaert J., Claeysen S., Compan V., and Dumuis A. 5-HT4 receptors. Curr Drug Targets CNS Neurol Disord 3 (2004) 39-51
107. Galligan J.J. Ligand-gated ion channels in the enteric nervous system. Neurogastroenterol Motil 14 (2002) 611-623
108. Kozlowski C.M., Green A., Grundy D., Boissonade F.M., and Bountra C. The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 46 (2000) 474-480
109. Chang L., Chey W.D., Harris L., Olden K., Surawicz C., and Schoenfeld P. Incidence of ischemic colitis and serious complications of constipation among patients using alosteron: systematic review of clinical trials and post-marketing surveillance data. Am J Gastroenterol 101 (2006) 1069-1148
110. Liu M., Geddis M.S., Wen Y., Setlik W., and Gershon M.D. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Am J Physiol Gastrointest Liver Physiol 289 (2005) G1148-1163
111. Pasricha P.J. Desperately seeking serotonin. A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders. Gastroenterology 132 (2007) 2287-2377
112. 2B receptor antagonist in vitro and in vivo. Br J Pharmacol 143 (2004) 549-560
113. Tonini M., Vicini R., Cervio E., et al. 5-HT(7) receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology 129 (2005) 1557-1566
114. Camilleri M., Vazquez-Roque M.I., Burton D., et al. Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans. Neurogastroenterol Motil 19 (2007) 30-38
115. Evangelista S. Drug evaluation: pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. Curr Opin Investig Drugs 8 (2007) 416-422
116. Camilleri M., Kerstens R., Rykx A., and Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 29 358 (2008) 2344-2354
117. Drossman D.A., Whitehead W.E., and Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 112 (1997) 2120-2137