The 5-HT 4 receptor agonist, tegaserod, is a potent 5-HT 2B receptor antagonist in vitro and in vivo

British Journal of Pharmacology

Volumn 143, Issue 5, 2004, Pages 549-560

  Beattie, D T ^a   Smith, J A M ^a   Marquess, D ^a   Vickery, R G ^a   Armstrong, S R ^a   Pulido Rios, T ^a   McCullough, J L ^a   Sandlund, C ^a   Richardson, C ^a   Mai, N ^a   Humphrey, P P A ^a  

^a THERAVANCE INC   (United States)

Author keywords

5 HT 2B; 5 HT 4; Gastrointestinal motility; Stomach fundus; Tegaserod

Indexed keywords

1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; ALPHA METHYLSEROTONIN; CYCLIC AMP; RECOMBINANT RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; SEROTONIN 4C RECEPTOR; TEGASEROD; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ESOPHAGUS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; GUINEA PIG; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; STOMACH FUNDUS; ANIMAL; CELL CULTURE; CELL MEMBRANE; COLON; DRUG EFFECT; METABOLISM; MUSCLE CONTRACTION; PRESSURE; PROTEIN BINDING; RADIOASSAY; RAT; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; COLON; CYCLIC AMP; ESOPHAGUS; GASTRIC FUNDUS; GASTROINTESTINAL TRANSIT; GUINEA PIGS; INDOLES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PRESSURE; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 8744318249     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705929     Document Type: Article

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