Expression of chemokine receptors CXCR4, CXCR5 and CCR7 on B and T lymphocytes from patients with primary antibody deficiency

Clinical and Experimental Immunology

Volumn 156, Issue 2, 2009, Pages 254-262

  Payne, D ^b   Drinkwater, S ^b   Baretto, R ^b   Duddridge, M ^b   Browning, M J ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Antibody deficiency; Chemokine; Common variable immunodeficiency; Immunodeficiency; Lymphocyte; Receptor

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; IMMUNOGLOBULIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; LYMPHOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADULT; B-LYMPHOCYTES; CASE-CONTROL STUDIES; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; RECEPTORS, CCR7; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; RECEPTORS, CXCR5; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES;

EID: 64649096503     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.03889.x     Document Type: Article

References (32)

1. Stein JV, Nombela-Arrieta C. Chemokine control of lymphocyte trafficking: a general overview. Immunology 2005 116 : 1 12.
2. Cozine CL, Wolniak KL, Waldschmidt TJ. The primary germinal center response in mice. Curr Opin Immunol 2005 17 : 298 302.
3. Badolato R. Leukocyte circulation: one-way or round trip? Lessons from primary immunodeficiency patients. J Leukoc Biol 2004 76 : 1 6.
4. Hernandez PA, Gorlin RJ, Lukens JN et al. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat Genet 2003 34 : 70 4.
5. Moratto D, Gulino AV, Fontana S et al. Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients. Clin Immunol 2006 121 : 203 14.
6. Fevang B, Yndestad A, Damas JK et al. Chemokines and common variable immunodeficiency; possible contribution of the fractalkine system. Clin Immunol 2009 130 : 151 61.
7. Taubenheim N, von Hornung M, Durandy A et al. Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients. J Immunol 2005 175 : 5498 503.
8. Grimbacher B, Hutloff A, Schlesier M et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 2003 4 : 261 8.
9. Sander CA, Medeiros LJ, Weiss LM, Yano T, Sneller MC, Jaffe ES. Lymphoproliferative lesions in patients with common variable immunodeficiency syndrome. Am J Surg Pathol 1992 16 : 1170 82.
10. Van der Brande P, Geboes K, Vantrappen G et al. Intestinal nodular lymphoid hyperplasia in patients with common variable immunodeficiency: local accumulation of B and CD8(+) lymphocytes. J Clin Immunol 1988 8 : 296 306.
11. Sacco O, Fregonese B, Picco P et al. Common variable immunodeficiency presenting in a girl as lung infiltrates and mediastinal adenopathies leading to severe 'superior vena caval' syndrome. Eur Respir J 1996 9 : 1958 61.
12. Warnatz K, Denz A, Drager R et al. Severe deficiency of switched memory B cells (CD27+IgM-IgD-) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002 99 : 1544 51.
13. Ferry BL, Jones J, Bateman EA et al. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol 2005 140 : 532 9.
14. Pandolfi F, Paganelli R, Cafaro A et al. Abnormalities of lymphocyte subpopulations in CVI do not correlate with increased production of IL-6. Immunodeficiency 1993 4 : 19 23.
15. Aukrust P, Muller F, Froland SS. Elevated serum levels of interleukin-4 and interleukin-6 in patients with common variable immunodeficiency (CVI) are associated with chronic immune activation and low numbers of CD4+ T lymphocytes. Clin Immunol Immunopathol 1994 70 : 217 24.
16. Piqueras B, Lavenu-Bombled C, Galicier L et al. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003 23 : 385 400.
17. Henneken M, Dorner T, Burmester G-R, Berek C. Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 2005 7 : R1001 13.
18. Hansen A, Reiter K, Ziprian T et al. Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjogren's syndrome. Arthritis Rheum 2005 21 : 2109 19.
19. Maurer D, Fischer GF, Fae I et al. IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol 1992 148 : 3700 5.
20. Agematsu K, Nagumo H, Yang FC et al. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol 1997 27 : 2073 9.
21. Ko J, Radigan L, Cunningham-Rundles C. Immune competence and switched memory B cells in common variable immunodeficiency. Clin Immunol 2005 116 : 37 41.
22. Alachkar H, Taubenheim N, Haeney MR, Durandy A, Arkwright PD. Memory switched B cell percentage and not serum immunoglobulin production is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency. Clin Immunol 2006 120 : 310 18.
23. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999 401 : 708 12.
24. Randolph DA, Huang G, Carruthers CJ, Bromley LE, Chaplin DD. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo. Science 1999 286 : 2159 62.
25. Amyes E, McMichael AJ, Callan MF. Human CD4+ T cells are predominantly distributed among six phenotypically and functionally distinct subsets. J Immunol 2005 175 : 5765 73.
26. Breitfeld D, Ohl L, Kremmer E et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000 192 : 1545 52.
27. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000 192 : 1553 62.
28. Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G. Follicular B helper T cell activity is confined to CXCR5(hi) ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006 37 : 1892 903.
29. Shi GX, Harrison K, Wilson GL, Moratz C, Kehrl JH. RGS13 regulates germinal centre B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13. J Immunol 2002 169 : 2507 15.
30. Balabanian K, Levoye A, Klemm L et al. Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signalling. J Clin Invest 2008 118 : 1074 84.
31. Holm AM, Aukrust P, Damas JK, Muller F, Halvorsen B, Froland SS. Abnormal interleukin-7 function in common variable immunodeficiency. Blood 2005 105 : 2887 90.
32. Chapel H, Lucas M, Lee M et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 2008 112 : 277 86.