Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients

Clinical Immunology

Volumn 121, Issue 2, 2006, Pages 203-214

  Moratto, Daniele ^a   Gulino, Anna Virginia ^a   Fontana, Stefania ^a   Mori, Luigi ^a   Pirovano, Silvia ^b   Soresina, Annarosa ^a   Meini, Antonella ^a   Imberti, Luisa ^b   Notarangelo, Luigi Daniele ^a   Plebani, Alessandro ^a   Badolato, Raffaele ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b Terzo Servizio Analisi   (Italy)

Author keywords

B lymphocytes; CD19hi CD21lo B cells; CD23; CD27; Hypogammaglobulinemia; T lymphocytes

Indexed keywords

CD19 ANTIGEN; CD4 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HYPOGAMMAGLOBULINEMIA; IMMUNOPHENOTYPING; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT INFECTION; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGAMMAGLOBULINEMIA; ANTIGENS, CD19; B-LYMPHOCYTE SUBSETS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; RECEPTORS, CCR7; RECEPTORS, CHEMOKINE; RECEPTORS, COMPLEMENT 3D; RECEPTORS, CXCR5; T-LYMPHOCYTE SUBSETS;

EID: 33750143588     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.07.003     Document Type: Article

References (45)

1. Cunningham-Rundles C., and Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin. Immunol. 92 (1999) 34-48
2. Sneller M.C., Strober W., Eisenstein E., Jaffe J.S., and Cunningham-Rundles C. NIH conference. New insights into common variable immunodeficiency. Ann. Intern. Med. 118 (1993) 720-730
3. Pirofsky B. Intravenous immune globulin therapy in hypogammaglobulinemia. A review. Am. J. Med. 76 (1984) 53-60
4. Busse P.J., Razvi S., and Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J. Allergy Clin. Immunol. 109 (2002) 1001-1004
5. Grimbacher B., Hutloff A., Schlesier M., Glocker E., Warnatz K., Drager R., Eibel H., Fischer B., Schaffer A.A., Mages H.W., Kroczek R.A., and Peter H.H. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 4 (2003) 261-268
6. Spickett G.P., Farrant J., North M.E., Zhang J.G., Morgan L., and Webster A.D. Common variable immunodeficiency: how many diseases?. Immunol. Today 18 (1997) 325-328
7. Salzer U., Chapel H.M., Webster A.D., Pan-Hammarstrom Q., Schmitt-Graeff A., Schlesier M., Peter H.H., Rockstroh J.K., Schneider P., Schaffer A.A., Hammarstrom L., and Grimbacher B. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 37 (2005) 820-828
8. Castigli E., Wilson S.A., Garibyan L., Rachid R., Bonilla F., Schneider L., and Geha R.S. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet. 37 (2005) 829-834
9. Losi C.G., Silini A., Fiorini C., Soresina A., Meini A., Ferrari S., Notarangelo L.D., Lougaris V., and Plebani A. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J. Clin. Immunol. 25 (2005) 496-502
10. Bryant A., Calver N.C., Toubi E., Webster A.D., and Farrant J. Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin. Immunol. Immunopathol. 56 (1990) 239-248
11. Warnatz K., Denz A., Drager R., Braun M., Groth C., Wolff-Vorbeck G., Eibel H., Schlesier M., and Peter H.H. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 99 (2002) 1544-1551
12. Klein U., Rajewsky K., and Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188 (1998) 1679-1689
13. Piqueras B., Lavenu-Bombled C., Galicier L., Bergeron-van der Cruyssen F., Mouthon L., Chevret S., Debre P., Schmitt C., and Oksenhendler E. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J. Clin. Immunol. 23 (2003) 385-400
14. Agematsu K., Futatani T., Hokibara S., Kobayashi N., Takamoto M., Tsukada S., Suzuki H., Koyasu S., Miyawaki T., Sugane K., Komiyama A., and Ochs H.D. Absence of memory B cells in patients with common variable immunodeficiency. Clin. Immunol. 103 (2002) 34-42
15. Warnatz K., Wehr C., Drager R., Schmidt S., Eibel H., Schlesier M., and Peter H.H. Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia. Immunobiology 206 (2002) 502-513
16. Ko J., Radigan L., and Cunningham-Rundles C. Immune competence and switched memory B cells in common variable immunodeficiency. Clin. Immunol. 116 (2005) 37-41
17. Conley M.E., Notarangelo L.D., and Etzioni A. Diagnostic criteria for primary immunodeficiencies. Clin. Immunol. 93 (1999) 190-197
18. Sullivan K., Chapel H., Orange J., and Cunningham-Rundles C. Primary immunodeficiency diseases consortium conference. Clin. Immunol. 116 (2005) 279-280
19. Gulino A.V., Moratto D., Sozzani S., Cavadini P., Otero K., Tassone L., Imberti L., Pirovano S., Notarangelo L.D., Soresina R., Mazzolari E., Nelson D.L., Notarangelo L.D., and Badolato R. Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome. Blood 104 (2004) 444-452
20. Zhang L., Lewin S.R., Markowitz M., Lin H.H., Skulsky E., Karanicolas R., He Y., Jin X., Tuttleton S., Vesanen M., Spiegel H., Kost R., van Lunzen J., Stellbrink H.J., Wolinsky S., Borkowsky W., Palumbo P., Kostrikis L.G., and Ho D.D. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J. Exp. Med. 190 (1999) 725-732
21. Agematsu K. Memory B cells and CD27. Histol. Histopathol. 15 (2000) 573-576
22. Klein U., Tu Y., Stolovitzky G.A., Keller J.L., Haddad Jr. J., Miljkovic V., Cattoretti G., Califano A., and Dalla-Favera R. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2639-2644
23. Muller G., Hopken U.E., Stein H., and Lipp M. Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J. Leukocyte Biol. 72 (2002) 1-8
24. Muller G., and Lipp M. Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking. Microcirculation 10 (2003) 325-334
25. Kruger G., Welte K., Ciobanu N., Cunningham-Rundles C., Ralph P., Venuta S., Feldman S., Koziner B., Wang C.Y., and Moore M.A. Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency. J. Clin. Immunol. 4 (1984) 295-303
26. Pastorelli G., Roncarolo M.G., Touraine J.L., Peronne G., Tovo P.A., and de Vries J.E. Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens. Clin. Exp. Immunol. 78 (1989) 334-340
27. Sneller M.C., and Strober W. Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency. J. Immunol. 144 (1990) 3762-3769
28. Fischer M.B., Hauber I., Eggenbauer H., Thon V., Vogel E., Schaffer E., Lokaj J., Litzman J., Wolf H.M., and Mannhalter J.W. A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency. Blood 84 (1994) 4234-4241
29. Stagg A.J., Funauchi M., Knight S.C., Webster A.D., and Farrant J. Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID). Clin. Exp. Immunol. 96 (1994) 48-53
30. Kondratenko I., Amlot P.L., Webster A.D., Farrant J., and MRC Immunodeficiency Group. Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen-specific memory T cells. Clin. Exp. Immunol. 108 (1997) 9-13
31. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
32. Campbell J.J., Murphy K.E., Kunkel E.J., Brightling C.E., Soler D., Shen Z., Boisvert J., Greenberg H.B., Vierra M.A., Goodman S.B., Genovese M.C., Wardlaw A.J., Butcher E.C., and Wu L. CCR7 expression and memory T cell diversity in humans. J. Immunol. 166 (2001) 877-884
33. Schaerli P., Loetscher P., and Moser B. Cutting edge: induction of follicular homing precedes effector Th cell development. J. Immunol. 167 (2001) 6082-6086
34. Guazzi V., Aiuti F., Mezzaroma I., Mazzetta F., Andolfi G., Mortellaro A., Pierdominici M., Fantini R., Marziali M., and Aiuti A. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles. Clin. Exp. Immunol. 129 (2002) 346-353
35. Isgro A., Marziali M., Mezzaroma I., Luzi G., Mazzone A.M., Guazzi V., Andolfi G., Cassani B., Aiuti A., and Aiuti F. Bone marrow clonogenic capability, cytokine production, and thymic output in patients with common variable immunodeficiency. J. Immunol. 174 (2005) 5074-5081
36. Bonnefoy J.Y., Henchoz S., Hardie D., Holder M.J., and Gordon J. A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis. Eur. J. Immunol. 23 (1993) 969-972
37. Fischer M.B., Goerg S., Shen L., Prodeus A.P., Goodnow C.C., Kelsoe G., and Carroll M.C. Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science 280 (1998) 582-585
38. Carroll M. Role of complement receptors CD21/CD35 in B lymphocyte activation and survival. Curr. Top. Microbiol. Immunol. 246 (1999) 63-68
39. Nakayama T., Hieshima K., Izawa D., Tatsumi Y., Kanamaru A., and Yoshie O. Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J. Immunol. 170 (2003) 1136-1140
40. Sims G.P., Ettinger R., Shirota Y., Yarboro C.H., Illei G.G., and Lipsky P.E. Identification and characterization of circulating human transitional B cells. Blood 105 (2005) 4390-4398
41. Sato S., Steeber D.A., Jansen P.J., and Tedder T.F. CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. J. Immunol. 158 (1997) 4662-4669
42. Su I., and Tarakhovsky A. B-1 cells: orthodox or conformist?. Curr. Opin. Immunol. 12 (2000) 191-194
43. Martin F., and Kearney J.F. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13 (2001) 195-201
44. Iglesias J., Matamoros N., Raga S., Ferrer J.M., and Mila J. CD95 expression and function on lymphocyte subpopulations in common variable immunodeficiency (CVID); related to increased apoptosis. Clin. Exp. Immunol. 117 (1999) 138-146
45. Hsueh R.C., and Scheuermann R.H. Tyrosine kinase activation in the decision between growth, differentiation, and death responses initiated from the B cell antigen receptor. Adv. Immunol. 75 (2000) 283-316