Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects

Journal of Clinical Immunology

Volumn 23, Issue 5, 2003, Pages 385-400

  Piqueras, B ^a,d   Lavenu Bombled, C ^a   Galicier, L ^b   Bergeron Van Der Cruyssen, F ^a   Mouthon, L ^c   Chevret, S ^b   Debre P ^e   Schmitt, C ^a   Oksenhendler, E ^b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c AVICENNE HOSPITAL   (France)

^d BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

^e NONE

Author keywords

B cell memory; CD27; Classification; CVID

Indexed keywords

B7 ANTIGEN; CD27 ANTIGEN; CD57 ANTIGEN; CD86 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; FAS ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN D; INTERLEUKIN 2 RECEPTOR;

ADULT; AGED; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL FEATURE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GRANULOMATOSIS; HUMAN; LYMPHOID CELL; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; PATIENT CODING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC MUTATION; SPLENOMEGALY; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD27; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; T-LYMPHOCYTES;

EID: 0042332029     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025373601374     Document Type: Article

References (25)

1. Sneller MC, Strober W, Eisenstein E, Jaffe JS, Cunningham-Rundles C: NIH conference. New insights into common variable immunodeficiency. Ann Intern Med 118:720-730, 1993
2. Hermaszewski RA, Webster AD: Primary hypogammaglobulinaemia: A survey of clinical manifestations and complications. Q J Med 86:31-42, 1993
3. Rosen FS, Cooper MD, Wedgwood RJ: The primary immunodeficiencies. N Engl J Med 333:431-440, 1995
4. Cunningham-Rundles C, Bodian C: Common variable immunodeficiency: Clinical and immunological features of 248 patients. Clin Immunol 92:34-48, 1999
5. Primary immunodeficiency diseases. Report of an IUIS scientific committee. Clin Exp Immunol 118(Suppl 1):1-28, 1999
6. Bryant A, Calver NC, Toubi E, Webster AD, Farrant J: Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin Immunol Immunopathol 56:239-248, 1990
7. Tangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE: Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 188:1691-1703, 1998
8. Maurer D, Holter W, Majdic O, Fischer GF, Knapp W: CD27 expression by a distinct subpopulation of human B lymphocytes. Eur J Immunol 20:2679-2684, 1990
9. Agematsu K, Nagumo H, Yang FC, Nakazawa T, Fukushima K, Ito S, Sugita K, Mori T, Kobata T, Morimoto C, Komiyama A: B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol 27:2073-2079, 1997
10. Klein U, Rajewsky K, Kuppers R: Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188:1679-1689, 1998
11. Agematsu K, Nagumo H, Shinozaki K, Hokibara S, Yasui K, Terada K, Kawamura N, Toba T, Nonoyama S, Ochs HD, Komiyama A: Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome. J Clin Invest 102:853-860, 1998
12. Weller S, Faili A, Garcia C, Braun MC, Le Deist FF, de Saint Basile GG, Hermine O, Fischer A, Reynaud CA, Weill JC: CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci USA 98:1166-1170, 2001
13. Brouet JC, Chedeville A, Fermand JP, Royer B: Study of the B cell memory compartment in common variable immunodeficiency. Eur J Immunol 30:2516-2520, 2000
14. Jacquot S, Macon-Lemaitre L, Paris E, Kobata T, Tanaka Y, Morimoto C, Schlossman SF, Tron F: B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients. Int Immunol 13:871-876, 2001
15. Agematsu K, Futatani T, Hokibara S, Kobayashi N, Takamoto M, Tsukada S, Suzuki H, Koyasu S, Miyawaki T, Sugane K, Komiyama A, Ochs HD: Absence of memory B cells in patients with common variable immunodeficiency. Clin Immunol 103:34-42, 2002
16. Warnatz K, Denz A, Drager R, Braun M, Groth C, Wolff-Vorbeck G, Eibel H, Schlesier M, Peter HH: Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: A new approach to classify a heterogeneous disease. Blood 99:1544-1551, 2002
17. Levy Y, Gupta N, Le Deist F, Garcia C, Fischer A, Weill JC, Reynaud CA: Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome. Proc Natl Acad Sci USA 95:13135-13140, 1998
18. Bonhomme D, Hammarstrom L, Webster D, Chapel H, Hermine O, Le Deist F, Lepage E, Romeo PH, Levy Y: Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency. J Immunol 165:4725-4730, 2000
19. Mechanic LJ, Dikman S, Cunningham-Rundles C: Granulomatous disease in common variable immunodeficiency. Ann Intern Med 127:613-617, 1997
20. Agematsu K, Kobata T, Yang FC, Nakazawa T, Fukushima K, Kitahara M, Mori T, Sugita K, Morimoto C, Komiyama A: CD27/CD70 interaction directly drives B cell IgG and IgM synthesis. Eur J Immunol 25:2825-2829, 1995
21. Jacquot S, Kobata T, Iwata S, Morimoto C, Schlossman SF: CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: Enhancement of plasma cell differentiation by CD27 signaling. J Immunol 159:2652-2657, 1997
22. Reynaud CA, Garcia C, Hein WR, Weill JC: Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115-125, 1995
23. Mullighan CG, Fanning GC, Chapel HM, Welsh KI: TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: Role in the pathogenesis of granulomatous disease. J Immunol 159:6236-6241, 1997
24. Wright JJ, Wagner DK, Blaese RM, Hagengruber C, Waldmann TA, Fleisher TA: Characterization of common variable immunodeficiency: Identification of a subset of patients with distinctive immunophenotypic and clinical features. Blood 76:2046-2051, 1990
25. Groth C, Drager R, Warnatz K, Wolff-Vorbeck G, Schmidt S, Eibel H, Schlesier M, Peter HH: Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol 129:133-139, 2002