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1
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10644231649
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The germinal center response
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K.L. Wolniak, S.M. Shinall, and T.J. Waldschmidt The germinal center response Crit Rev Immunol 24 2004 39 66 A comprehensive review of the GC response in humans and rodents. The review details current knowledge of GC formation and maturation, its key components, various model systems used to study the GC, and key molecules involved in the GC reaction.
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(2004)
Crit Rev Immunol
, vol.24
, pp. 39-66
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Wolniak, K.L.1
Shinall, S.M.2
Waldschmidt, T.J.3
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2
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0025726702
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In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations
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J. Jacob, R. Kassir, and G. Kelsoe In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations J Exp Med 173 1991 1165 1175
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(1991)
J Exp Med
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, pp. 1165-1175
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Jacob, J.1
Kassir, R.2
Kelsoe, G.3
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3
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0026670190
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In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl) acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
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J. Jacob, and G. Kelsoe In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers J Exp Med 176 1992 679 687
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(1992)
J Exp Med
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Jacob, J.1
Kelsoe, G.2
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4
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0027305024
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In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl) acetyl. III. The kinetics of V region mutation and selection in the germinal center B cells
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J. Jacob, J. Przylepa, C. Miller, and G. Kelsoe In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V region mutation and selection in the germinal center B cells J Exp Med 178 1993 1293 1307
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(1993)
J Exp Med
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Jacob, J.1
Przylepa, J.2
Miller, C.3
Kelsoe, G.4
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5
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0034082121
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Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens
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S.M. Shinall, M. Gonzalez-Fernandez, R.J. Noelle, and T.J. Waldschmidt Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens J Immunol 164 2000 5729 5738
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(2000)
J Immunol
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, pp. 5729-5738
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Shinall, S.M.1
Gonzalez-Fernandez, M.2
Noelle, R.J.3
Waldschmidt, T.J.4
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6
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0030909902
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Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells
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J.G. Tew, J. Wu, D. Qin, S. Helm, G.F. Burton, and A.K. Szakal Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells Immunol Rev 156 1997 39 52
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(1997)
Immunol Rev
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Tew, J.G.1
Wu, J.2
Qin, D.3
Helm, S.4
Burton, G.F.5
Szakal, A.K.6
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8
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0030587821
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Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG response in vitro
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J. Wu, D. Qin, G.F. Burton, A.K. Szakal, and J.G. Tew Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG response in vitro J Immunol 157 1996 3404 3411
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(1996)
J Immunol
, vol.157
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Wu, J.1
Qin, D.2
Burton, G.F.3
Szakal, A.K.4
Tew, J.G.5
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9
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0032211091
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Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses
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D. Qin, J. Wu, M.C. Carroll, G.F. Burton, A.K. Szakal, and J.G. Tew Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses J Immunol 161 1998 4549 4554
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(1998)
J Immunol
, vol.161
, pp. 4549-4554
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Qin, D.1
Wu, J.2
Carroll, M.C.3
Burton, G.F.4
Szakal, A.K.5
Tew, J.G.6
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10
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1542317525
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FcγRII expression on follicular dendritic cells and immunoreceptor tyrosine-based inhibition motif signaling in B cells
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Y. Aydar, J. Wu, J. Song, A.K. Szakal, and J.G. Tew FcγRII expression on follicular dendritic cells and immunoreceptor tyrosine-based inhibition motif signaling in B cells Eur J Immunol 34 2004 98 107 This study explored the mechanism by which FcγRII expression on FDCs can enhance an antigen-induced immune response. The authors demonstrated that immune complexes bind to the FcγRII on the FDCs, resulting in decreased immune-complex-induced immunoreceptor tyrosine-based inhibition motif signaling through the FcγRII on B cells.
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(2004)
Eur J Immunol
, vol.34
, pp. 98-107
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Aydar, Y.1
Wu, J.2
Song, J.3
Szakal, A.K.4
Tew, J.G.5
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11
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0034659826
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Fcγ receptor IIB on follicular dendritic cells regulates the B cell recall response
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D. Qin, J. Wu, K.A. Vora, J.V. Ravetch, A.K. Szakal, T. Manser, and J.G. Tew Fcγ receptor IIB on follicular dendritic cells regulates the B cell recall response J Immunol 164 2000 6268 6275
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(2000)
J Immunol
, vol.164
, pp. 6268-6275
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Qin, D.1
Wu, J.2
Vora, K.A.3
Ravetch, J.V.4
Szakal, A.K.5
Manser, T.6
Tew, J.G.7
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12
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0037103335
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Differential expression of the inhibitory IgG Fc receptor FcγRIIB on germinal center cells: Implications for selection of high-affinity B cells
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S.P. Rao, K.A. Vora, and T. Manser Differential expression of the inhibitory IgG Fc receptor FcγRIIB on germinal center cells: implications for selection of high-affinity B cells J Immunol 169 2002 1859 1868
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(2002)
J Immunol
, vol.169
, pp. 1859-1868
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Rao, S.P.1
Vora, K.A.2
Manser, T.3
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13
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0036772765
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Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation
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Y. Aydar, P. Balogh, J.G. Tew, and A.K. Szakal Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation Eur J Immunol 32 2002 2817 2826
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(2002)
Eur J Immunol
, vol.32
, pp. 2817-2826
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Aydar, Y.1
Balogh, P.2
Tew, J.G.3
Szakal, A.K.4
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14
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0345016411
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Altered regulation of FcγRII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation
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Y. Aydar, P. Balogh, J.G. Tew, and A.K. Szakal Altered regulation of FcγRII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation J Immunol 171 2003 5975 5987 This paper demonstrates a second mechanism by which aged FDCs fail to drive an immune response. In situ analysis identified a defect in the expression of FcγRII on FDC reticula in aged mice. In vitro studies of aged FDCs revealed a deficiency in stimulation of young memory B cells that was dependent on B cell expression of FcγRII.
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(2003)
J Immunol
, vol.171
, pp. 5975-5987
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Aydar, Y.1
Balogh, P.2
Tew, J.G.3
Szakal, A.K.4
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15
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0141678842
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Chemokines in the systemic organization of immunity
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D.J. Campbell, C.H. Kim, and E.C. Butcher Chemokines in the systemic organization of immunity Immunol Rev 195 2003 58 71
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(2003)
Immunol Rev
, vol.195
, pp. 58-71
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Campbell, D.J.1
Kim, C.H.2
Butcher, E.C.3
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16
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0036431533
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Traffic patterns of B cells and plasma cells
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J.G. Cyster, K.M. Ansel, V.N. Ngo, D.C. Hargraves, and T.T. Lu Traffic patterns of B cells and plasma cells Adv Exp Med Biol 512 2002 35 41
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(2002)
Adv Exp Med Biol
, vol.512
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Cyster, J.G.1
Ansel, K.M.2
Ngo, V.N.3
Hargraves, D.C.4
Lu, T.T.5
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17
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0034691531
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A chemokine driven positive feedback loop organizes lymphoid follicles
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K.M. Ansel, V.N. Ngo, P. Hyman, S. Luther, R. Forster, J. Sedgwick, J. Browning, M. Lipp, and J.G. Cyster A chemokine driven positive feedback loop organizes lymphoid follicles Nature 406 2000 309 314
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(2000)
Nature
, vol.406
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Ansel, K.M.1
Ngo, V.N.2
Hyman, P.3
Luther, S.4
Forster, R.5
Sedgwick, J.6
Browning, J.7
Lipp, M.8
Cyster, J.G.9
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18
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0030582773
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A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
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R. Forster, A. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen Cell 87 1996 1037 1047
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Cell
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Forster, R.1
Mattis, A.2
Kremmer, E.3
Wolf, E.4
Brem, G.5
Lipp, M.6
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19
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0033955708
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CXCR5 deficient mice develop functional germinal centers in the splenic T cell zone
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I. Voigt, S.A. Camacho, B. deBoer, M. Lipp, R. Forster, and C. Berek CXCR5 deficient mice develop functional germinal centers in the splenic T cell zone Eur J Immunol 30 2000 560 567
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(2000)
Eur J Immunol
, vol.30
, pp. 560-567
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Voigt, I.1
Camacho, S.A.2
Deboer, B.3
Lipp, M.4
Forster, R.5
Berek, C.6
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22
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0142188050
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Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice
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Z.S.M. Rahman, S.P. Rao, S.L. Kalled, and T. Manser Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice J Exp Med 198 2003 1157 1169
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(2003)
J Exp Med
, vol.198
, pp. 1157-1169
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Rahman, Z.S.M.1
Rao, S.P.2
Kalled, S.L.3
Manser, T.4
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24
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8644227902
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The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
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Y. Nie, J. Waite, F. Brewer, M.-J. Sunshine, D.R. Littman, and Y.-R. Zou The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity J Exp Med 200 2004 1145 1156 Mice with selective B-cell deficiency of CXCR4 were created to elucidate the role this chemokine plays in peripheral B-cell homeostasis and function. The authors found that GCs form aberrantly, but T cell-dependent responses do not appear to be compromised.
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(2004)
J Exp Med
, vol.200
, pp. 1145-1156
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Nie, Y.1
Waite, J.2
Brewer, F.3
Sunshine, M.-J.4
Littman, D.R.5
Zou, Y.-R.6
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25
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0032701695
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In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
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K.M. Ansel, L.J. McHeyzer-Williams, V.N. Ngo, M.G. McHeyzer-Williams, and J.G. Cyster In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines J Exp Med 190 1999 1123 1134
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J Exp Med
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, pp. 1123-1134
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Ansel, K.M.1
McHeyzer-Williams, L.J.2
Ngo, V.N.3
McHeyzer-Williams, M.G.4
Cyster, J.G.5
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27
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0037460115
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Lymphocyte traffic control by chemokines: Follicular B helper T cells
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B. Moser, and L. Ebert Lymphocyte traffic control by chemokines: follicular B helper T cells Immunol Lett 85 2003 105 112
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(2003)
Immunol Lett
, vol.85
, pp. 105-112
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Moser, B.1
Ebert, L.2
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28
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9144258465
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Cutting edge: TCR revision occurs in germinal centers
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C.J. Cooper, G.L. Turk, M. Sun, A.G. Farr, and P.J. Fink Cutting edge: TCR revision occurs in germinal centers J Immunol 173 2004 6532 6536
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(2004)
J Immunol
, vol.173
, pp. 6532-6536
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Cooper, C.J.1
Turk, G.L.2
Sun, M.3
Farr, A.G.4
Fink, P.J.5
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30
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2942586926
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CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation
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Y. Xiao, J. Hendriks, P. Langerak, H. Jacobs, and J. Borst CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation J Immunol 172 2004 7432 7441 This study demonstrated that CD27, a marker of human memory B cells, is expressed transiently on murine GC centroblasts. Although CD27 is not required for murine GC formation, it plays a role in enhancing the GC response.
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(2004)
J Immunol
, vol.172
, pp. 7432-7441
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Xiao, Y.1
Hendriks, J.2
Langerak, P.3
Jacobs, H.4
Borst, J.5
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31
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0345016435
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Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses
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V.S. Raman, R.S. Akondy, S. Rath, V. Bal, and A. George Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses J Immunol 171 2003 5876 5881
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(2003)
J Immunol
, vol.171
, pp. 5876-5881
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Raman, V.S.1
Akondy, R.S.2
Rath, S.3
Bal, V.4
George, A.5
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33
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0038446862
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Cutting edge: Germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function
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K.A. Vora, L.C. Wang, S.P. Rao, Z. Liu, G.R. Majeau, A.H. Cutler, P.S. Hochman, M.L. Scott, and S.L. Kalled Cutting edge: Germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function J Immunol 171 2003 547 551 This paper addressed the role of BAFF in murine GC maintenance by neutralizing this factor with a soluble BAFF receptor and by examining BAFF-null mice. The authors demonstrated GCs could be initiated in the absence of BAFF, but the duration of the GC was decreased. Additionally, they demonstrated SHM was intact, although there was an attenuation of the high-affinity antibody response.
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(2003)
J Immunol
, vol.171
, pp. 547-551
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Vora, K.A.1
Wang, L.C.2
Rao, S.P.3
Liu, Z.4
Majeau, G.R.5
Cutler, A.H.6
Hochman, P.S.7
Scott, M.L.8
Kalled, S.L.9
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