Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients

Journal of Immunology

Volumn 175, Issue 8, 2005, Pages 5498-5503

  Taubenheim, Nadine ^a   Von Hornung, Marcus ^a   Durandy, Anne ^b   Warnatz, Klaus ^a   Corcoran, Lynn ^c   Peter, Hans Hartmut ^a   Eibel, Hermann ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN BCL 6; PROTEIN BLIMP 1; SYNDECAN 1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BACTERIAL INFECTION; CELL DIFFERENTIATION; CELL MATURATION; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT INFECTION;

EID: 26844459829     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.8.5498     Document Type: Article

References (35)

1. International Union of Immunological Societies. 1999. Primary immunodeficiency diseases. Report of an IUIS Scientific Committee. Clin. Exp. Immunol. 118(Suppl. 1): 1-28.
2. Cunningham-Rundles, C., and C. Bodian. 1999. Common variable immunodeficiency, clinical and immunological features of 248 patients. Clin. Immunol. 92: 34-48.
3. Grimbacher, B., A. Hutloff, M. Schlesier, E. Glocker, K. Warnatz, R. Drager, H. Eibel, B. Fischer, A. A. Schaffer, H. W. Mages, et al. 2003. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 4: 261-268.
4. North, M. E., A. D. Webster, and J. Farrant. 1991. Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. Clin. Exp. Immunol 85: 198-201.
5. Rump, J. A., A. Jahreis, M. Schlesier, R. Drager, I. Melchers, and H. H. Peter. 1992. Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency. Clin. Exp. Immunol. 89: 204-210.
6. -) B cells from patients with common variable immunodeficiency (CVID). Clin. Exp. Immunol. 129: 133-139.
7. Denz, A., H. Eibel, H. Illges, G. Kienzle, M. Schlesier, and H. H. Peter. 2000. Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients. Eur. J. Immunol. 30: 1069-1077.
8. Eisenstein, E. M., and W. Strober. 1995. Evidence for a generalized signaling abnormality in B cells from patients with common variable immunodeficiency. Adv. Exp. Med. Biol. 371B: 699-704.
9. Levy, Y., N. Gupta, F. Le Deist, C. Garcia, A. Fischer, J. C. Weill, and C. A. Reynaud. 1998. Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome. Proc. Natl. Acad. Sci. USA 95: 13135-13140.
10. -) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 99: 1544-1551.
11. Brouet, J. C., A. Chedeville, J. P. Fermand, and B. Royer. 2000. Study of the B cell memory compartment in common variable immunodeficiency. Eur. J. Immunol. 30: 2516-2520.
12. Agematsu, K., T. Futatani, S. Hokibara, N. Kobayashi, M. Takamoto, S. Tsukada, H. Suzuki, S. Koyasu, T. Miyawaki, K. Sugane, et al. 2002. Absence of memory B cells in patients with common variable immunodeficiency. Clin. Immunol. 103: 34-42.
13. Piqueras, B., C. Lavenu-Bombled, L. Galicier, F. Bergeron-van der Cruyssen, L. Mouthon, S. Chevret, P. Debre, C. Schmitt, and E. Oksenhendler. 2003. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J. Clin. Immunol. 23: 385-400.
14. Allman, D., A. Jain, A. Dent, R. R. Maile, T. Selvaggi, M. R. Kehry, and L. M. Staudt. 1996. BCL-6 expression during B-cell activation. Blood 87: 5257-5268.
15. Cattoretti, G., C. C. Chang, K. Cechova, J. Zhang, B. H. Ye, B. Falini, D. C. Louie, K. Offit, R. S. Chaganti, and R. Dalla-Favera. 1995. BCL-6 protein is expressed in germinal-center B cells. Blood 86: 45-53.
16. Onizuka, T., M. Moriyama, T. Yamochi, T. Kuroda, A. Kazama, N. Kanazawa, K. Sato, T. Kato, H. Ota, and S. Mori. 1995. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86: 28-37.
17. Keller, A. D., and T. Maniatis. 1992. Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Mol. Cell Biol. 12: 1940-1949.
18. Turner, C. A., Jr., D. H. Mack, and M. M. Davis. 1994. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77: 297-306.
19. Kallies, A., J. Hasbold, D. M. Tarlinton, W. Dietrich, L. M. Corcoran, P. D. Hodgkin, and S. L. Nutt. 2004. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J. Exp. Med. 200: 967-977.
20. Durandy, A., C. Schiff, J. Y. Bonnefoy, M. Forveille, F. Rousset, G. Mazzei, M. Milili, and A. Fischer. 1993. Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X-linked hyper IgM syndrome. Eur. J. Immunol. 23: 2294-2299.
21. Imai, K., N. Catalan, A. Plebani, L. Marodi, O. Sanal, S. Kumaki, V. Nagendran, P. Wood, C. Glastre, F. Sarrot-Reynauld, et al. 2003. Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination. J. Clin. Invest. 112: 136-142.
22. Colucci, F., C. Soudais, E. Rosmaraki, L. Vanes, V. L. Tybulewicz, and J. P. Di Santo. 1999. Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation. J. Immunol. 162: 2761-2765.
23. Angelin-Duclos, C., G. Cattoretti, K. I. Lin, and K. Calame. 2000. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. J. Immunol. 165: 5462-5471.
24. Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13: 199-212.
25. Dent, A. L., A. L. Shaffer, X. Yu, D. Allman, and L. M. Staudt. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589-592.
26. Ye, B. H., G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, R. S. Chaganti, et al. 1997. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16: 161-170.
27. Shapiro-Shelef, M., K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams, and K. Calame. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607-620.
28. Shaffer, A. L., A. Rosenwald, E. M. Hurt, J. M. Giltnane, L. T. Lam, O. K. Pickeral, and L. M. Staudt. 2001. Signatures of the immune response. Immunity 15: 375-385.
29. Shaffer, A. L., K. I. Lin, T. C. Kuo, X. Yu, E. M. Hurt, A. Rosenwald, J. M. Giltnane, L. Yang, H. Zhao, K. Calame, and L. M. Staudt. 2002. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17: 51-62.
30. Chalfie, M., Y. Tu, G. Euskirchen, W. W. Ward, and D. C. Prasher. 1994. Green fluorescent protein as a marker for gene expression. Science 263: 802-805.
31. Li, X., X. Zhao, Y. Fang, X. Jiang, T. Duong, C. Fan, C. C. Huang, and S. R. Kain. 1998. Generation of destabilized green fluorescent protein as a transcription reporter. J. Biol. Chem. 273: 34970-34975.
32. Chang, D. H., C. Angelin-Duclos, and K. Calame. 2000. BLIMP-1: trigger for differentiation of myeloid lineage. Nat. Immunol. 1: 169-176.
33. Reimold, A. M., N. N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E. M. Gravallese, D. Friend, M. J. Grusby, F. Alt, and L. H. Glimcher. 2001. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300-307.
34. Reimold, A. M., A. Etkin, I. Clauss, A. Perkins, D. S. Friend, J. Zhang, H. F. Horton, A. Scott, S. H. Orkin, M. C. Byrne, et al. 2000. An essential role in liver development for transcription factor XBP-1. Genes Dev. 14: 152-157.
35. Bryant, A., N. C. Calver, E. Toubi, A. D. Webster, and J. Farrant. 1990. Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin. Immunol. Immunopathol. 56: 239-248.