메뉴 건너뛰기




Volumn 286, Issue 1 55-1, 2004, Pages

Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells

Author keywords

Angiogenesis; Kinetics; Mathematical or computational model; Receptor ligand interactions; Synergy

Indexed keywords

GROWTH FACTOR; PLACENTAL GROWTH FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 0345737075     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00254.2003     Document Type: Article
Times cited : (115)

References (59)
  • 1
    • 0037093078 scopus 로고    scopus 로고
    • Placental growth factor is a survival factor for tumor endothelial cells and macrophages
    • Adini A, Kornaga T, Firoozbakht F, and Benjamin LE. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res 62: 2749-2752, 2002.
    • (2002) Cancer Res , vol.62 , pp. 2749-2752
    • Adini, A.1    Kornaga, T.2    Firoozbakht, F.3    Benjamin, L.E.4
  • 2
    • 0031689569 scopus 로고    scopus 로고
    • Role of placenta growth factor (P1GF) in human extravillous trophoblast proliferation, migration and invasiveness
    • Athanassiades A and Lala PK. Role of placenta growth factor (P1GF) in human extravillous trophoblast proliferation, migration and invasiveness. Placenta 19: 465-473, 1998.
    • (1998) Placenta , vol.19 , pp. 465-473
    • Athanassiades, A.1    Lala, P.K.2
  • 3
    • 0031954222 scopus 로고    scopus 로고
    • The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a soluble form: Implications for tumor angiogenesis
    • Barillari G, Albonici L, Franzese O, Modesti A, Liberati F, Barillari P, Ensoli B, Manzari V, and Santeusanio G. The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a soluble form: implications for tumor angiogenesis. Am J Pathol 152: 1161-1166, 1998.
    • (1998) Am J Pathol , vol.152 , pp. 1161-1166
    • Barillari, G.1    Albonici, L.2    Franzese, O.3    Modesti, A.4    Liberati, F.5    Barillari, P.6    Ensoli, B.7    Manzari, V.8    Santeusanio, G.9
  • 4
    • 0030609013 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells
    • Barleon B, Siemeister G, Martiny-Baron G, Weindel K, Herzog C, and Marme D. Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res 57: 5421-5425, 1997.
    • (1997) Cancer Res , vol.57 , pp. 5421-5425
    • Barleon, B.1    Siemeister, G.2    Martiny-Baron, G.3    Weindel, K.4    Herzog, C.5    Marme, D.6
  • 5
    • 0027146418 scopus 로고
    • Fluorescence photobleaching with spatial Fourier analysis: Measurement of diffusion in light-scattering media
    • Berk DA, Yuan F, Leunig M, and Jain RK. Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media. Biophys J 65: 2428-2436, 1993.
    • (1993) Biophys J , vol.65 , pp. 2428-2436
    • Berk, D.A.1    Yuan, F.2    Leunig, M.3    Jain, R.K.4
  • 6
    • 0025944147 scopus 로고
    • Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects
    • Bikfalvi A, Sauzeau C, Moukadiri H, Maclouf J, Busso N, Bryckaert M, Plouet J, and Tobelem G. Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: binding, internalization, degradation, and biological effects. J Cell Physiol 149: 50-59, 1991.
    • (1991) J Cell Physiol , vol.149 , pp. 50-59
    • Bikfalvi, A.1    Sauzeau, C.2    Moukadiri, H.3    Maclouf, J.4    Busso, N.5    Bryckaert, M.6    Plouet, J.7    Tobelem, G.8
  • 7
    • 0030030668 scopus 로고    scopus 로고
    • Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression
    • Brogi E, Schatteman G, Wu T, Kim EA, Varticovski L, Keyt B, and Isner JM. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J Clin Invest 97: 469-476, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 469-476
    • Brogi, E.1    Schatteman, G.2    Wu, T.3    Kim, E.A.4    Varticovski, L.5    Keyt, B.6    Isner, J.M.7
  • 8
    • 0034848647 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide
    • Bussolati B, Dunk C, Grohman M, Kontos CD, Mason J, and Ahmed A. Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. Am J Pathol 159: 993-1008, 2001.
    • (2001) Am J Pathol , vol.159 , pp. 993-1008
    • Bussolati, B.1    Dunk, C.2    Grohman, M.3    Kontos, C.D.4    Mason, J.5    Ahmed, A.6
  • 11
    • 0029929716 scopus 로고    scopus 로고
    • The vascular endothelial, growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
    • Clauss M, Weich H, Breier G, Knies U, Rockl W, Waltenberger J, and Risau W. The vascular endothelial, growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 271: 17629-17634, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17629-17634
    • Clauss, M.1    Weich, H.2    Breier, G.3    Knies, U.4    Rockl, W.5    Waltenberger, J.6    Risau, W.7
  • 12
    • 0033603346 scopus 로고    scopus 로고
    • Characterization of vascular endothelial cell growth factor interactions with the kinase insert domain-containing receptor tyrosine kinase. A real time kinetic study
    • Cunningham SA, Tran TM, Arrate MP, and Brock TA. Characterization of vascular endothelial cell growth factor interactions with the kinase insert domain-containing receptor tyrosine kinase. A real time kinetic study. J Biol Chem 274: 18421-18427, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 18421-18427
    • Cunningham, S.A.1    Tran, T.M.2    Arrate, M.P.3    Brock, T.A.4
  • 13
    • 0034781147 scopus 로고    scopus 로고
    • Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation
    • Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, and Munn LL. Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvasc Res 61: 203-210, 2001.
    • (2001) Microvasc Res , vol.61 , pp. 203-210
    • Dull, R.O.1    Yuan, J.2    Chang, Y.S.3    Tarbell, J.4    Jain, R.K.5    Munn, L.L.6
  • 15
    • 0034673136 scopus 로고    scopus 로고
    • Potentiation and inhibition of bFGF binding by heparin: A model for regulation of cellular response
    • Fannon M, Forsten KE, and Nugent MA. Potentiation and inhibition of bFGF binding by heparin: a model for regulation of cellular response. Biochemistry 39: 1434-1445, 2000.
    • (2000) Biochemistry , vol.39 , pp. 1434-1445
    • Fannon, M.1    Forsten, K.E.2    Nugent, M.A.3
  • 16
    • 0029999241 scopus 로고    scopus 로고
    • Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate
    • Fannon M and Nugent MA. Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate. J Biol Chem 271: 17949-17956, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17949-17956
    • Fannon, M.1    Nugent, M.A.2
  • 17
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77: 527-543, 1999.
    • (1999) J Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 18
    • 0032764427 scopus 로고    scopus 로고
    • Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    • Fong GH, Zhang L, Bryce DM, and Peng J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 126: 3015-3025, 1999.
    • (1999) Development , vol.126 , pp. 3015-3025
    • Fong, G.H.1    Zhang, L.2    Bryce, D.M.3    Peng, J.4
  • 19
    • 0034698012 scopus 로고    scopus 로고
    • Potential mechanisms for the regulation of growth factor binding by heparin
    • Forsten KE, Fannon M, and Nugent MA. Potential mechanisms for the regulation of growth factor binding by heparin. J Theor Biol 205: 215-230, 2000.
    • (2000) J Theor Biol , vol.205 , pp. 215-230
    • Forsten, K.E.1    Fannon, M.2    Nugent, M.A.3
  • 20
    • 0036376677 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA
    • Freedman SB, Vale P, Kalka C, Kearney M, Pieczek A, Symes J, Losordo D, and Isner JM. Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA. Hum Gene Ther 13: 1595-1603, 2002.
    • (2002) Hum Gene Ther , vol.13 , pp. 1595-1603
    • Freedman, S.B.1    Vale, P.2    Kalka, C.3    Kearney, M.4    Pieczek, A.5    Symes, J.6    Losordo, D.7    Isner, J.M.8
  • 21
    • 0031106311 scopus 로고    scopus 로고
    • Morphology favors an endothelial cell pathway for longitudinal conduction within arterioles
    • Haas TL and Duling BR. Morphology favors an endothelial cell pathway for longitudinal conduction within arterioles. Microvasc Res 53: 113-120, 1997.
    • (1997) Microvasc Res , vol.53 , pp. 113-120
    • Haas, T.L.1    Duling, B.R.2
  • 22
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • Hiratsuka S, Maru Y, Okada A, Seiki M, Noda T, and Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 61: 1207-1213, 2001.
    • (2001) Cancer Res , vol.61 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 23
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiolgenesis in mice
    • Hiratsuka S, Minowa O, Kuno J, Noda T, and Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiolgenesis in mice. Proc Natl Acad Sci USA 95: 9349-9354, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 24
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck KA, Leung DW, Rowland AM, Winer J, and Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 25
    • 0032573553 scopus 로고    scopus 로고
    • Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance
    • Huang X, Gottstein C, Brekken RA, and Thorpe PE. Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance. Biochem Biophys Res Commun 252: 643-648, 1998.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 643-648
    • Huang, X.1    Gottstein, C.2    Brekken, R.A.3    Thorpe, P.E.4
  • 27
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
    • Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, Shibuya M, and Sato Y. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19: 2138-2146, 2000.
    • (2000) Oncogene , vol.19 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3    Terai, Y.4    Ito, M.5    Shitara, K.6    Tabayashi, K.7    Shibuya, M.8    Sato, Y.9
  • 28
    • 0029002297 scopus 로고
    • Molecular/cell engineering approach to autocrine ligand control of cell function
    • Lauffenburger DA, Forsten KE, Will B, and Wiley HS. Molecular/cell engineering approach to autocrine ligand control of cell function. Ann Biomed Eng 23: 208-215, 1995.
    • (1995) Ann Biomed Eng , vol.23 , pp. 208-215
    • Lauffenburger, D.A.1    Forsten, K.E.2    Will, B.3    Wiley, H.S.4
  • 30
    • 0022449843 scopus 로고
    • Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta
    • Levesque MJ, Liepsch D, Moravec S, and Nerem RM. Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta. Arteriosclerosis 6: 220-229, 1986.
    • (1986) Arteriosclerosis , vol.6 , pp. 220-229
    • Levesque, M.J.1    Liepsch, D.2    Moravec, S.3    Nerem, R.M.4
  • 32
    • 0036828280 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma
    • Lip PL, Felmeden DC, Blann AD, Matheou N, Thakur S, Cunliffe IA, and Lip GY. Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma. Br J Ophthalmol 86: 1299-1302, 2002.
    • (2002) Br J Ophthalmol , vol.86 , pp. 1299-1302
    • Lip, P.L.1    Felmeden, D.C.2    Blann, A.D.3    Matheou, N.4    Thakur, S.5    Cunliffe, I.A.6    Lip, G.Y.7
  • 33
    • 0034524141 scopus 로고    scopus 로고
    • Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia
    • Livingston JC, Chin R, Haddad B, McKinney ET, Ahokas R, and Sibai BM. Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia. Am J Obstet Gynecol 183: 1554-1557, 2000.
    • (2000) Am J Obstet Gynecol , vol.183 , pp. 1554-1557
    • Livingston, J.C.1    Chin, R.2    Haddad, B.3    McKinney, E.T.4    Ahokas, R.5    Sibai, B.M.6
  • 34
    • 0035476882 scopus 로고    scopus 로고
    • Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domaincontaining receptor
    • Lu D, Jimenez X, Zhang H, Wu Y, Bohlen P, Witte L, and Zhu Z. Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domaincontaining receptor. Cancer Res 61: 7002-7008, 2001.
    • (2001) Cancer Res , vol.61 , pp. 7002-7008
    • Lu, D.1    Jimenez, X.2    Zhang, H.3    Wu, Y.4    Bohlen, P.5    Witte, L.6    Zhu, Z.7
  • 37
    • 0036085390 scopus 로고    scopus 로고
    • Blockade of in vivo VEGF-mediated angiogenesis by antisense gene therapy: Role of Flk-1 and Flt-1 receptors
    • Marchand GS, Noiseux N, Tanguay JF, and Sirois MG. Blockade of in vivo VEGF-mediated angiogenesis by antisense gene therapy: role of Flk-1 and Flt-1 receptors. Am J Physiol Heart Circ Physiol 282: H194-H204, 2002.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Marchand, G.S.1    Noiseux, N.2    Tanguay, J.F.3    Sirois, M.G.4
  • 38
    • 4244078727 scopus 로고    scopus 로고
    • VEGF receptor signal transduction
    • Matsumoto T and Claesson-Welsh L. VEGF receptor signal transduction. Sci STKE 2001: RE21, 2001.
    • (2001) Sci STKE , vol.2001
    • Matsumoto, T.1    Claesson-Welsh, L.2
  • 39
    • 0025991563 scopus 로고
    • Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites
    • Myoken Y, Kayada Y, Okamoto T, Kan M, Sato GH, and Sato JD. Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites. Proc Natl Acad Sci USA 88: 5819-5823, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5819-5823
    • Myoken, Y.1    Kayada, Y.2    Okamoto, T.3    Kan, M.4    Sato, G.H.5    Sato, J.D.6
  • 40
    • 0035143709 scopus 로고    scopus 로고
    • Differential expression of VEGF isoforms in mouse during development and in the adult
    • Ng YS, Rohan R, Sunday ME, Demello DE, and D'Amore PA. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220: 112-121, 2001.
    • (2001) Dev Dyn , vol.220 , pp. 112-121
    • Ng, Y.S.1    Rohan, R.2    Sunday, M.E.3    Demello, D.E.4    D'Amore, P.A.5
  • 42
    • 0037252531 scopus 로고    scopus 로고
    • Levels of placenta growth factor in gestational trophoblastic diseases
    • Okamoto T, Niu R, Mizutani S, and Yamada S. Levels of placenta growth factor in gestational trophoblastic diseases. Am J Obstet Gynecol 188: 135-140, 2003.
    • (2003) Am J Obstet Gynecol , vol.188 , pp. 135-140
    • Okamoto, T.1    Niu, R.2    Mizutani, S.3    Yamada, S.4
  • 43
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park JE, Chen HH, Winer J, Houck KA, and Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 269: 25646-25654, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 44
    • 0001475562 scopus 로고    scopus 로고
    • Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia
    • Reuvekamp A, Velsing-Aarts FV, Poulina IE, Capello JJ, and Duits AJ. Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia. BrJ Obstet Gynaecol 106: 1019-1022. 1999.
    • (1999) BrJ Obstet Gynaecol , vol.106 , pp. 1019-1022
    • Reuvekamp, A.1    Velsing-Aarts, F.V.2    Poulina, I.E.3    Capello, J.J.4    Duits, A.J.5
  • 45
    • 0032491429 scopus 로고    scopus 로고
    • Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
    • Shen BQ, Lee DY, Gerber HP, Keyt BA, Ferrara N, and Zioncheck TF. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro. J Biol Chem 273: 29979-29985, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 29979-29985
    • Shen, B.Q.1    Lee, D.Y.2    Gerber, H.P.3    Keyt, B.A.4    Ferrara, N.5    Zioncheck, T.F.6
  • 46
    • 0034805462 scopus 로고    scopus 로고
    • Spatial range of autocrine signaling: Modeling and computational analysis
    • Shvartsman SY, Wiley HS, Deen WM, and Lauffenburger DA. Spatial range of autocrine signaling: modeling and computational analysis. Biophys J 81: 1854-1867, 2001,
    • (2001) Biophys J , vol.81 , pp. 1854-1867
    • Shvartsman, S.Y.1    Wiley, H.S.2    Deen, W.M.3    Lauffenburger, D.A.4
  • 47
    • 0032558391 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells
    • Sperinde GV and Nugent MA. Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells. Biochemistry 37: 13153-13164, 1998.
    • (1998) Biochemistry , vol.37 , pp. 13153-13164
    • Sperinde, G.V.1    Nugent, M.A.2
  • 48
    • 0026833077 scopus 로고
    • Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses
    • Starbuck C and Lauffenburger DA. Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotechnol Prog 8: 132-143, 1992.
    • (1992) Biotechnol Prog , vol.8 , pp. 132-143
    • Starbuck, C.1    Lauffenburger, D.A.2
  • 49
    • 0035688408 scopus 로고    scopus 로고
    • Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor. FLT-1, inhibit the growth of C6 glioma in a mouse xenograft
    • Stefanik DF, Fellows WK, Rizkalla LR, Rizkalla WM, Stefanik PP, Deleo AB, and Welch WC. Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor. FLT-1, inhibit the growth of C6 glioma in a mouse xenograft, J Neurooncol 55: 91-100, 2001.
    • (2001) J Neurooncol , vol.55 , pp. 91-100
    • Stefanik, D.F.1    Fellows, W.K.2    Rizkalla, L.R.3    Rizkalla, W.M.4    Stefanik, P.P.5    Deleo, A.B.6    Welch, W.C.7
  • 50
    • 0035049357 scopus 로고    scopus 로고
    • An autocrine loop mediates expression of vascular endothelial growth factor in human dermal microvascular endothelial cells
    • Vega-Diaz B, Herron GS, and Michel S. An autocrine loop mediates expression of vascular endothelial growth factor in human dermal microvascular endothelial cells. J Invest Dermatol 116: 525-530, 2001.
    • (2001) J Invest Dermatol , vol.116 , pp. 525-530
    • Vega-Diaz, B.1    Herron, G.S.2    Michel, S.3
  • 51
    • 0036883534 scopus 로고    scopus 로고
    • Characterization of the vascular endothelial growth factor-receptor interaction and determination of the recombinant protein by an optical receptor sensor
    • Von Tiedemann B and Bilitewski U. Characterization of the vascular endothelial growth factor-receptor interaction and determination of the recombinant protein by an optical receptor sensor. Biosens Bioelectron 17: 983-991, 2002.
    • (2002) Biosens Bioelectron , vol.17 , pp. 983-991
    • Von Tiedemann, B.1    Bilitewski, U.2
  • 53
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt 1, two receptors for vascular endothelial growth factor
    • Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, and Heldin CH. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-26995, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 55
    • 0036845084 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: Relative roles of KDR and Flt-1 receptors
    • Yang S, Toy K, Ingle G, Zlot C, Williams PM, Fuh G, Li B, de Vos A, and Gerritsen ME. Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors. Arterioscler Thromb Vasc Biol 22: 1797-1803, 2002.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1797-1803
    • Yang, S.1    Toy, K.2    Ingle, G.3    Zlot, C.4    Williams, P.M.5    Fuh, G.6    Li, B.7    De Vos, A.8    Gerritsen, M.E.9
  • 56
    • 0035895711 scopus 로고    scopus 로고
    • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    • Zachary I and Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581, 2001.
    • (2001) Cardiovasc Res , vol.49 , pp. 568-581
    • Zachary, I.1    Gliki, G.2
  • 57
    • 0035920244 scopus 로고    scopus 로고
    • Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways
    • Zeng H, Dvorak HF, and Mukhopadhyay D. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem 276: 26969-26979, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 26969-26979
    • Zeng, H.1    Dvorak, H.F.2    Mukhopadhyay, D.3
  • 58
    • 0031079738 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is the major angiogenic factor in omentum: Mechanism of the omentum-mediated angiogenesis
    • Zhang QX, Magovern CJ, Mack CA, Budenbender KT, Ko W, and Rosengart TK. Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res 67: 147-154, 1997.
    • (1997) J Surg Res , vol.67 , pp. 147-154
    • Zhang, Q.X.1    Magovern, C.J.2    Mack, C.A.3    Budenbender, K.T.4    Ko, W.5    Rosengart, T.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.