Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-β on tropoelastin mRNA in lung fibroblasts

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 291, Issue 2, 2006, Pages

  DiCamillo, Sandra J ^a   Yang, Shenghong ^a   Panchenko, Maria V ^a   Toselli, Paul A ^a   Naggar, Estee F ^a   Rich, Celeste B ^a   Stone, Phillip J ^a   Nugent, Matthew A ^a   Panchenko, Mikhail P ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Elastin; Epidermal growth factor receptor; Extracellular signal regulated kinases 1 and 2; Mitogen activated protein kinase kinase; Transforming growth factor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ELASTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; LEUKOCYTE ELASTASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TROPOELASTIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME RELEASE; LUNG FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA STABILITY;

ANIMALS; AUTOCRINE COMMUNICATION; CELL LINE; DICHLORORIBOFURANOSYLBENZIMIDAZOLE; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTE ELASTASE; LUNG; MAP KINASE KINASE 1; MICE; NUCLEIC ACID SYNTHESIS INHIBITORS; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TROPOELASTIN;

EID: 33744830716     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00530.2005     Document Type: Article

References (42)

1. Berk JL, Franzblau C, and Goldstein RH. Recombinant interleukin-1β inhibits elastin formation by a neonatal rat lung fibroblast subtype. J Biol Chem 266: 3192-3197, 1991.
2. Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, and Nugent MA. Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol 31: 344-350, 2004.
3. Burri PH and Weibel ER. Ultrastructure and morphometry of the developing lung. In: Development of the Lung. Part 1: Structural Development, edited by Hodson WA. New York: Marcel Dekker, 1977, p. 215-268.
4. Damiano VV, Tsang A, Kucich U, Abrams WR, Rosenbloom J, Kimbel P, Fallahnejad M, and Weinbaum G. Immunolocalization of elastase in human emphysematous lungs. J Clin Invest 78: 482-493, 1986.
5. DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nugent MA, Foster JA, and Panchenko MP. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem 277: 18938-18946, 2002.
6. Dubick MA, Rucker RB, Cross CE, and Last JA. Elastin metabolism in rodent lung. Biochim Biophys Acta 672: 303-306, 1981.
7. Ganser GL, Stricklin GP, and Matrisian LM. EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases. Int J Dev Biol 35: 453-461, 1991.
8. Hew Y, Grzelczak Z, Lau C, and Keeley FW. Identification of a large region of secondary structure in the 3′-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. J Biol Chem 274: 14415-14421, 1999.
9. Hoidal JR and Niewoehner DE. Pathogenesis of emphysema. Chest 83: 679-685, 1983.
10. Hornstra IK, Birge S, Starcher B, Bailey AJ, Mecham RP, and Shapiro SD. Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem 278: 14387-14393, 2003.
11. Kagan HM and Sullivan KA. Lysyl oxidase: preparation and role in elastin biosynthesis. Methods Enzymol 82 Pt. A: 637-650, 1982.
12. Kahari VM, Chen YQ, Bashir MM, Rosenbloom J, and Uitto J. Tumor necrosis factor-α down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. J Biol Chem 267: 26134-26141, 1992.
13. Kheradmand F, Rishi K, and Werb Z. Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci 115: 839-848, 2002.
14. Kohri K, Ueki IF, and Nadel JA. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol 283: L531-L540, 2002.
15. Kucich U, Rosenbloom JC, Abrams WR, Bashir MM, and Rosenbloom J. Stabilization of elastin mRNA by TGF-β: initial characterization of signaling pathway. Am J Respir Cell Mol Biol 17:10 -16, 1997.
16. Kucich U, Rosenbloom JC, Abrams WR, and Rosenbloom J. Transforming growth factor-β stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-δ, and p38. Am J Respir Cell Mol Biol 26: 183-188, 2002.
17. Le Cras TD, Hardie WD, Deutsch GH, Albertine KH, Ikegami M, Whitsett JA, and Korfhagen TR. Transient induction of TGF-α disrupts lung morphogenesis causing pulmonary disease in adulthood. Am J Physiol Lung Cell Mol Physiol 287: L718-L729, 2004.
18. Liu J, Rich CB, Buczek-Thomas JA, Nugent MA, Panchenko MP, and Foster JA. Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 285: L1106-L1115, 2003.
19. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, and Li T. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet 36: 178-182, 2004.
20. Lucattelli M, Bartalesi B, Cavarra E, Fineschi S, Lunghi B, Martorana PA, and Lungarella G. Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. Respir Res 6: 83-97, 2005.
21. McGowan SE, Jackson SK, Olson PJ, Parekh T, and Gold LI. Exogenous and endogenous transforming growth factors-β influence elastin gene expression in cultured lung fibroblasts. Am J Respir Cell Mol Biol 17: 25-35, 1997.
22. McGowan SE and McNamer R. Transforming growth factor-β increases elastin production by neonatal rat lung fibroblasts. Am J Respir Cell Mol Biol 3: 369-376, 1990.
23. Mecham RP. Elastic fibers. In: The Lung: Scientific Foundations, edited by Crystal RG, West JB, Weibel ER, and Barnes PJ. Philadelphia, PA: Lippincott-Raven, 1997, p. 729-736.
24. Mercer BA, Kolesnikova N, Sonett J, and D'Armiento J. Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. J Biol Chem 279: 17690-17696, 2004.
25. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J Jr, Honjo T, and Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature 415: 171-175, 2002.
26. Noguchi A and Samaha H. Developmental changes in tropoelastin gene expression in the rat lung studied by in situ hybridization. Am J Respir Cell Mol Biol 5: 571-578, 1991.
27. Parks WC. Posttranscriptional regulation of lung elastin production. Am J Respir Cell Mol Biol 17: 1-2, 1997.
28. Pierce RA, Mariani TJ, and Senior RM. Elastin in lung development and disease. Ciba Found Symp 192: 199-212, 1995.
29. Reid PT and Sallenave JM. Cytokines in the pathogenesis of chronic obstructive pulmonary disease. Curr Pharm Des 9: 25-38, 2003.
30. Rich CB, Carreras I, Lucey EC, Jaworski JA, Buczek-Thomas JA, Nugent MA, Stone P, and Foster JA. Transcriptional regulation of pulmonary elastin gene expression in elastase-induced injury. Am J Physiol Lung Cell Mol Physiol 285: L354-L362, 2003.
31. Rich CB, Nugent MA, Stone P, and Foster JA. Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in downregulation of elastin gene transcription. A role for basic fibroblast growth factor in regulating lung repair. J Biol Chem 271: 23043-23048, 1996.
32. Sakai LY, Keene DR, and Engvall E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol 103: 2499-2509, 1986.
33. Shapiro SD, Endicott SK, Province MA, Pierce JA, and Campbell EJ. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 87: 1828-1834, 1991.
34. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, and Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 163: 2329-2335, 2003.
35. Shapiro SD and Ingenito EP. The pathogenesis of chronic obstructive pulmonary disease. Advances in the past 100 years. Am J Respir Cell Mol Biol 32: 367-372, 2005.
36. Siegel PM and Massague J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat Rev Cancer 3: 807-821, 2003.
37. Snider GL, Ciccolella DE, Morris SM, Stone PJ, and Lucey EC. Putative role of neutrophil elastase in the pathogenesis of emphysema. Ann NY Acad Sci 624: 45-59, 1991.
38. Snider GL, Lucey EC, and Stone PJ. Animal models of emphysema. Am Rev Respir Dis 133: 149-169, 1986.
39. Wendel DP, Taylor DG, Albertine KH, Keating MT, and Li DY. Impaired distal airway development in mice lacking elastin. Am J Respir Cell Mol Biol 23: 320-326, 2000.
40. Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, and Olson EN. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415: 168-171, 2002.
41. Yee W, Wang J, Liu J, Tseu I, Kuliszewski M, and Post M. Glucocorticoid-induced tropoelastin expression is mediated via transforming growth factor-β3. Am J Physiol Lung Cell Mol Physiol 270: L992-L1001, 1996.
42. Zhang M, Pierce RA, Wachi H, Mecham RP, and Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor beta. Mol Cell Biol 9: 7314-7326, 1999.