The identification of novel PLC-γ inhibitors using virtual high throughput screening

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 8, 2009, Pages 3169-3176

  Reynisson, Jóhannes ^a   Court, William ^a   O'Neill, Ciaran ^a   Day, James ^a   Patterson, Lisa ^a   McDonald, Edward ^a   Workman, Paul ^a   Katan, Matilda ^a   Eccles, Suzanne A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Docking; Drug discovery; Oncology; PLC protein; Virtual screening

Indexed keywords

AMINE; CCT 129940; CCT 129950; CCT 129954; CCT 129957; CCT 129959; CCT 129960; CCT 129962; CCT 129967; CCT 129968; CCT 129970; CCT 129971; CCT 140222; CCT 196661; CCT 196664; CCT 196675; CCT 196677; CCT 196678; CCT 196681; CCT 196786; CCT 196787; INDOLE DERIVATIVE; INDORAMIN; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PHOSPHOLIPASE C DELTA; PHOSPHOLIPASE C GAMMA INHIBITOR; PHOSPHOLIPASE INHIBITOR; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHOSPHOLIPASE C GAMMA; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 64049103037     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.049     Document Type: Article

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