3β-hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 4, 2000, Pages 699-706

  Xie, Wenge ^a   Peng, Hairuo ^a   Zalkow, Leon H ^a   Li, Yu Hua ^a   Zhu, Cheng ^a   Powis, Garth ^b   Kunkel, Mark ^b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA HYDROXY 6 AZA CHOLESTANE; CHOLESTANE DERIVATIVE; UNCLASSIFIED DRUG; 3BETA-HYDROXY-6-AZA-CHOLESTANE; ANTINEOPLASTIC AGENT; CHOLESTANOL; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE; PHOSPHOLIPASE C;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL MIGRATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CANCER TRANSPLANTATION; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; MOUSE; MOUSE MUTANT; SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; CHOLESTANOLS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHOLIPASE C; SPECTRUM ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0033625178     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00014-6     Document Type: Article

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