-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124:783-801.
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
2
-
-
59749085907
-
MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease
-
Baril, M., M. E. Racine, F. Penin, and D. Lamarre. 2009. MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease. J. Virol. 83:1299-1311.
-
(2009)
J. Virol.
, vol.83
, pp. 1299-1311
-
-
Baril, M.1
Racine, M.E.2
Penin, F.3
Lamarre, D.4
-
3
-
-
36749069393
-
Interferons at age 50: Past, current and future impact on biomedicine
-
Borden, E. C., G. C. Sen, G. Uze, R. H. Silverman, R. M. Ransohoff, G. R. Foster, and G. R. Stark. 2007. Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6:975-990.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 975-990
-
-
Borden, E.C.1
Sen, G.C.2
Uze, G.3
Silverman, R.H.4
Ransohoff, R.M.5
Foster, G.R.6
Stark, G.R.7
-
4
-
-
21244460002
-
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases
-
DOI 10.1016/j.febslet.2005.05.071, PII S0014579305006976
-
Chin, C. N., J. N. Sachs, and D. M. Engelman. 2005. Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett. 579:3855-3858. (Pubitemid 40897735)
-
(2005)
FEBS Letters
, vol.579
, Issue.17
, pp. 3855-3858
-
-
Chin, C.-N.1
Sachs, J.N.2
Engelman, D.M.3
-
5
-
-
30044440012
-
Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4
-
Choi, S., E. Lee, S. Kwon, H. Park, J. Y. Yi, S. Kim, I. O. Han, Y. Yun, and E. S. Oh. 2005. Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4. J. Biol. Chem. 280:42573-42579.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42573-42579
-
-
Choi, S.1
Lee, E.2
Kwon, S.3
Park, H.4
Yi, J.Y.5
Kim, S.6
Han, I.O.7
Yun, Y.8
Oh, E.S.9
-
6
-
-
41949092999
-
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
-
Clément, J.-F., A. Bibeau-Poirier, S.-P. Gravel, N. Grandvaux, E. Bonneil, P. Thibault, S. Meloche, and M. J. Servant. 2008. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J. Virol. 82:3984-3996.
-
(2008)
J. Virol.
, vol.82
, pp. 3984-3996
-
-
Clément, J.-F.1
Bibeau-Poirier, A.2
Gravel, S.-P.3
Grandvaux, N.4
Bonneil, E.5
Thibault, P.6
Meloche, S.7
Servant, M.J.8
-
7
-
-
0038393016
-
IKKE and TBKI are essential components of the IRF3 signalling pathway
-
DOI 10.1038/ni921
-
Fitzgerald, K. A., S. M. McWhirter, K. L. Faia, D. C. Rowe, E. Latz, D. T. Golenbock, A. J. Coyle, S. M. Liao, and T. Maniatis. 2003. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4:491-496. (Pubitemid 36592443)
-
(2003)
Nature Immunology
, vol.4
, Issue.5
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
Coyle, A.J.7
Liao, S.-M.8
Maniatis, T.9
-
8
-
-
33744791510
-
Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus
-
Gitlin, L., W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R. A. Flavell, M. S. Diamond, and M. Colonna. 2006. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. USA 103:8459-8464.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8459-8464
-
-
Gitlin, L.1
Barchet, W.2
Gilfillan, S.3
Cella, M.4
Beutler, B.5
Flavell, R.A.6
Diamond, M.S.7
Colonna, M.8
-
9
-
-
34548129605
-
Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response
-
DOI 10.1016/j.cytogfr.2007.06.002, PII S1359610107000706
-
Hiscott, J. 2007. Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev. 18:483-490. (Pubitemid 47302822)
-
(2007)
Cytokine and Growth Factor Reviews
, vol.18
, Issue.5-6
, pp. 483-490
-
-
Hiscott, J.1
-
10
-
-
32044457700
-
MasterCARD: A priceless link to innate immunity
-
Hiscott, J., R. Lin, P. Nakhaei, and S. Paz. 2006. MasterCARD: a priceless link to innate immunity. Trends Mol. Med. 12:53-56.
-
(2006)
Trends Mol. Med.
, vol.12
, pp. 53-56
-
-
Hiscott, J.1
Lin, R.2
Nakhaei, P.3
Paz, S.4
-
11
-
-
0034623225
-
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
-
Inohara, N., T. Koseki, J. Lin, L. del Peso, P. C. Lucas, F. F. Chen, Y. Ogura, and G. Nunez. 2000. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 275:27823-27831.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27823-27831
-
-
Inohara, N.1
Koseki, T.2
Lin, J.3
Del Peso, L.4
Lucas, P.C.5
Chen, F.F.6
Ogura, Y.7
Nunez, G.8
-
12
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa, H., and G. N. Barber. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674-678.
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
13
-
-
0033859771
-
Receptor-like protein tyrosine phosphatase α homodimerizes on the cell surface
-
DOI 10.1128/MCB.20.16.5917-5929.2000
-
Jiang, G., J. den Hertog, and T. Hunter. 2000. Receptor-like protein tyrosine phosphatase homodimerizes on the cell surface. Mol. Cell. Biol. 20:5917-5929. (Pubitemid 30613041)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.16
, pp. 5917-5929
-
-
Jiang, G.1
Den Hertog, J.2
Hunter, T.3
-
14
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato, H., O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. S. Koh, C. Reis e Sousa, Y. Matsuura, T. Fujita, and S. Akira. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.
-
(2006)
Nature
, vol.441
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
Yamamoto, M.5
Matsui, K.6
Uematsu, S.7
Jung, A.8
Kawai, T.9
Ishii, K.J.10
Yamaguchi, O.11
Otsu, K.12
Tsujimura, T.13
Koh, C.S.14
Reis E Sousa, C.15
Matsuura, Y.16
Fujita, T.17
Akira, S.18
-
15
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai, T., K. Takahashi, S. Sato, C. Coban, H. Kumar, H. Kato, K. J. Ishii, O. Takeuchi, and S. Akira. 2005. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6:981-988.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
Kato, H.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
16
-
-
36448943427
-
DUBA: A deubiquitinase that regulates type I interferon production
-
Kayagaki, N., Q. Phung, S. Chan, R. Chaudhari, C. Quan, K. M. O'Rourke, M. Eby, E. Pietras, G. Cheng, J. F. Bazan, Z. Zhang, D. Arnott, and V. M. Dixit. 2007. DUBA: a deubiquitinase that regulates type I interferon production. Science 318:1628-1632.
-
(2007)
Science
, vol.318
, pp. 1628-1632
-
-
Kayagaki, N.1
Phung, Q.2
Chan, S.3
Chaudhari, R.4
Quan, C.5
O'Rourke, K.M.6
Eby, M.7
Pietras, E.8
Cheng, G.9
Bazan, J.F.10
Zhang, Z.11
Arnott, D.12
Dixit, V.M.13
-
17
-
-
33745814424
-
Essential role of IPS-1 in innate immune responses against RNA viruses
-
DOI 10.1084/jem.20060792
-
Kumar, H., T. Kawai, H. Kato, S. Sato, K. Takahashi, C. Coban, M. Yamamoto, S. Uematsu, K. J. Ishii, O. Takeuchi, and S. Akira. 2006. Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med. 203:1795-1803. (Pubitemid 44036284)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1795-1803
-
-
Kumar, H.1
Kawai, T.2
Kato, H.3
Sato, S.4
Takahashi, K.5
Coban, C.6
Yamamoto, M.7
Uematsu, S.8
Ishii, K.J.9
Takeuchi, O.10
Akira, S.11
-
18
-
-
0027050182
-
Sequence specificity in the dimerization of transmembrane alpha-helices
-
Lemmon, M. A., J. M. Flanagan, H. R. Treutlein, J. Zhang, and D. M. Engelman. 1992. Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry 31:12719-12725.
-
(1992)
Biochemistry
, vol.31
, pp. 12719-12725
-
-
Lemmon, M.A.1
Flanagan, J.M.2
Treutlein, H.R.3
Zhang, J.4
Engelman, D.M.5
-
19
-
-
2942700100
-
IIb subunit in cell membranes
-
DOI 10.1074/jbc.M314168200
-
Li, R., R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, and J. S. Bennett. 2004. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J. Biol. Chem. 279:26666-26673. (Pubitemid 38798824)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.25
, pp. 26666-26673
-
-
Li, R.1
Gorelik, R.2
Nanda, V.3
Law, P.B.4
Lear, J.D.5
Degrado, W.F.6
Bennett, J.S.7
-
20
-
-
29144462494
-
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
-
Li, X. D., L. Sun, R. B. Seth, G. Pineda, and Z. J. Chen. 2005. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc. Natl. Acad. Sci. USA 102:17717-17722.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17717-17722
-
-
Li, X.D.1
Sun, L.2
Seth, R.B.3
Pineda, G.4
Chen, Z.J.5
-
22
-
-
0037085373
-
The single transmembrane domains of ErbB receptors self-associate in cell membranes
-
Mendrola, J. M., M. B. Berger, M. C. King, and M. A. Lemmon. 2002. The single transmembrane domains of ErbB receptors self-associate in cell membranes. J. Biol. Chem. 277:4704-4712.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4704-4712
-
-
Mendrola, J.M.1
Berger, M.B.2
King, M.C.3
Lemmon, M.A.4
-
23
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-1172.
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
Bartenschlager, R.6
Tschopp, J.7
-
24
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
-
Oganesyan, G., S. K. Saha, B. Guo, J. Q. He, A. Shahangian, B. Zarnegar, A. Perry, and G. Cheng. 2006. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439:208-211.
-
(2006)
Nature
, vol.439
, pp. 208-211
-
-
Oganesyan, G.1
Saha, S.K.2
Guo, B.3
He, J.Q.4
Shahangian, A.5
Zarnegar, B.6
Perry, A.7
Cheng, G.8
-
25
-
-
33746479050
-
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
-
DOI 10.1038/sj.emboj.7601220, PII 7601220
-
Saha, S. K., E. M. Pietras, J. Q. He, J. R. Kang, S. Y. Liu, G. Oganesyan, A. Shahangian, B. Zarnegar, T. L. Shiba, Y. Wang, and G. Cheng. 2006. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25:3257-3263. (Pubitemid 44141784)
-
(2006)
EMBO Journal
, vol.25
, Issue.14
, pp. 3257-3263
-
-
Saha, S.K.1
Pietras, E.M.2
He, J.Q.3
Kang, J.R.4
Liu, S.-Y.5
Oganesyan, G.6
Shahangian, A.7
Zarnegar, B.8
Shiba, T.L.9
Wang, Y.10
Cheng, G.11
-
26
-
-
33846307026
-
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
-
Saito, T., R. Hirai, Y. M. Loo, D. Owen, C. L. Johnson, S. C. Sinha, S. Akira, T. Fujita, and M. Gale, Jr. 2007. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. USA 104:582-587.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 582-587
-
-
Saito, T.1
Hirai, R.2
Loo, Y.M.3
Owen, D.4
Johnson, C.L.5
Sinha, S.C.6
Akira, S.7
Fujita, T.8
Gale Jr., M.9
-
27
-
-
0038660668
-
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
-
Servant, M. J., N. Grandvaux, B. R. tenOever, D. Duguay, R. Lin, and J. Hiscott. 2003. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J. Biol. Chem. 278:9441-9447.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9441-9447
-
-
Servant, M.J.1
Grandvaux, N.2
TenOever, B.R.3
Duguay, D.4
Lin, R.5
Hiscott, J.6
-
28
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
-
Seth, R. B., L. Sun, C. K. Ea, and Z. J. Chen. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122:669-682.
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
29
-
-
0345802999
-
Sequence-specific dimerization of the transmembrane domain of the "BH3-only" protein BNIP3 in membranes and detergent
-
Sulistijo, E. S., T. M. Jaszewski, and K. R. MacKenzie. 2003. Sequence-specific dimerization of the transmembrane domain of the "BH3-only" protein BNIP3 in membranes and detergent. J. Biol. Chem. 278:51950-51956.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51950-51956
-
-
Sulistijo, E.S.1
Jaszewski, T.M.2
MacKenzie, K.R.3
-
30
-
-
33646592188
-
The specific and essential role of MAVS in antiviral innate immune responses
-
Sun, Q., L. Sun, H. H. Liu, X. Chen, R. B. Seth, J. Forman, and Z. J. Chen. 2006. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24:633-642.
-
(2006)
Immunity
, vol.24
, pp. 633-642
-
-
Sun, Q.1
Sun, L.2
Liu, H.H.3
Chen, X.4
Seth, R.B.5
Forman, J.6
Chen, Z.J.7
-
31
-
-
0141621240
-
A role for NF-κB essential modifier/IκB kinase-γ (NEMO/IKKγ) ubiquitination in the activation of the IκB kinase complex by tumor necrosis factor-α
-
DOI 10.1074/jbc.M303389200
-
Tang, E. D., C. Y. Wang, Y. Xiong, and K. L. Guan. 2003. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J. Biol. Chem. 278:37297-37305. (Pubitemid 37175246)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.39
, pp. 37297-37305
-
-
Tang, E.D.1
Wang, C.-Y.2
Xiong, Y.3
Guan, K.-L.4
-
32
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong, B., Y. Yang, S. Li, Y. Y. Wang, Y. Li, F. Diao, C. Lei, X. He, L. Zhang, P. Tien, and H. B. Shu. 2008. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29:538-550.
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
Yang, Y.2
Li, S.3
Wang, Y.Y.4
Li, Y.5
Diao, F.6
Lei, C.7
He, X.8
Zhang, L.9
Tien, P.10
Shu, H.B.11
|