Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus

Neuroscience

Volumn 160, Issue 1, 2009, Pages 227-239

  Wang, H ^a   Turner, J G ^a   Ling, L ^a   Parrish, J L ^a   Hughes, L F ^a   Caspary, D M ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aging; auditory; dorsal cochlear nucleus; gephyrin; glycine receptor; presbycusis

Indexed keywords

GEPHYRIN; GLYCINE RECEPTOR; PROTEIN SUBUNIT;

ARTICLE; COCHLEAR NUCLEUS; CONTROLLED STUDY; ENZYME REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; RAT;

AGING; ANIMALS; AUDITORY PERCEPTION; AUDITORY THRESHOLD; CARRIER PROTEINS; COCHLEAR NUCLEUS; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; MALE; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, INBRED F344; RECEPTORS, GLYCINE; RNA, MESSENGER;

EID: 63649157410     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.01.079     Document Type: Article

References (126)

1. Abbott S.D., Hughes L.F., Bauer C.A., Salvi R., and Caspary D.M. Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure. Neuroscience 93 (1999) 1375-1381
2. Allen P.D., Burkard R.F., Ison J.R., and Walton J.P. Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hear Res 186 (2003) 17-29
3. Banay-Schwartz M., Lajtha A., and Palkovits M. Changes with aging in the levels of amino acids in rat CNS structural elements II. Taurine and small neutral amino acids. Neurochem Res 14 (1989) 563-570
4. Battaini F., Del Vesco R., Govoni S., and Trabucchi M. Regulation of phorbol ester binding and protein kinase C activity in aged rat brain. Neurobiol Aging 11 5 (1990) 563-566
5. Battaini F., Elkabes S., Bergamaschi S., Ladisa V., Lucchi L., De Graan P.N., Schuurman T., Wetsel W.C., Trabucchi M., and Govoni S. Protein kinase C activity, translocation, and conventional isoforms in aging rat brain. Neurobiol Aging 16 2 (1995) 137-148
6. Battaini F., and Pascale A. Protein kinase C signal transduction regulation in physiological and pathological aging. Review. Ann N Y Acad Sci 1057 (2005) 177-192
7. Bauer C.A., Turner J.G., Caspary D.M., Myers K.S., and Brozoski T.J. Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma. J Neurosci Res 86 11 (2008) 2564-2578
8. Betz H., Kuhse J., Fischer M., Schmieden V., Laube B., Kuryatov A., Langosch D., Meyer G., Bormann J., and Rundström N. Structure, diversity and synaptic localization of inhibitory glycine receptors. Review. J Physiol Paris 88 4 (1994) 243-248
9. Betz H., Kuhse J., Schmieden V., Laube B., Kirsch J., and Harvey R.J. Structure and functions of inhibitory and excitatory glycine receptors. Review. Ann N Y Acad Sci 868 (1999) 667-676
10. Beyerl B.D. Afferent projections to the central nucleus of the inferior colliculus in the rat. Brain Res 145 2 (1978) 209-223
11. Brozoski T.J., Bauer C.A., and Caspary D.M. Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. J Neurosci 22 6 (2002) 2383-2390
12. Caspary D.M., Pazara K.E., Kössl M., and Faingold C.L. Strychnine alters the fusiform cell output from the dorsal cochlear nucleus. Brain Res 417 2 (1987) 273-282
13. Caspary D.M., Milbrandt J.C., and Helfert R.H. Central auditory aging: GABA changes in the inferior colliculus. Review. Exp Gerontol 30 3-4 (1995) 349-360
14. A receptor subunit composition and function in rat auditory system. Neuroscience 93 (1999) 307-312
15. Caspary D.M., Schatteman T.A., and Hughes L.F. Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs. J Neurosci 25 47 (2005) 10952-10959
16. Caspary D.M., Hughes L.F., Schatteman T.A., and Turner J.G. Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Hear Res 216-217 (2006) 207-215
17. Caspary D.M., Ling L., Turner J.G., and Hughes L.F. Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system. J Exp Biol 211 Pt 11 (2008) 1781-1791
18. Colombo P.J., Wetsel W.C., and Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc Natl Acad Sci U S A 94 25 (1997) 14195-14199
19. Colombo P.J., and Gallagher M. Individual differences in spatial memory among aged rats are related to hippocampal PKCgamma immunoreactivity. Hippocampus 12 2 (2002) 285-289
20. Cuervo A.M., and Dice J.F. When lysosomes get old. Review. Exp Gerontol 35 2 (2000) 119-131
21. Danglot L., Rostaing P., Triller A., and Bessis A. Morphologically identified glycinergic synapses in the hippocampus. Mol Cell Neurosci 27 4 (2004) 394-403
22. Davis K.A., and Young E.D. Pharmacological evidence of inhibitory and disinhibitory neuronal circuits in dorsal cochlear nucleus. J Neurophysiol 83 2 (2000) 926-940
23. Dazert S., Feldman M.L., and Keithley E.M. Cochlear spiral ganglion cell degeneration in wild-caught mice as a function of age. Hear Res 100 1-2 (1996) 101-106
24. Dice J.F. Altered intracellular protein degradation in aging: a possible cause of proliferative arrest. Exp Gerontol 24 5-6 (1989) 451-459
25. Doucet J.R., Ross A.T., Gillespie M.B., and Ryugo D.K. Glycine immunoreactivity of multipolar neurons in the ventral cochlear nucleus which project to the dorsal cochlear nucleus. J Comp Neurol 408 (1999) 515-531
26. Francis H.W., Ryugo D.K., Gorelikow M.J., Prosen C.A., and May B.J. The functional age of hearing loss in a mouse model of presbycusis. II. Neuroanatomical correlates. Hear Res 183 (2003) 29-36
27. Friauf E. Tonotopic order in the adult and developing auditory system of the rat as shown by c-fos immunocytochemistry. Eur J Neurosci 4 9 (1992) 798-812
28. Friguet B., Bulteau A.L., Chondrogianni N., Conconi M., and Petropoulos I. Protein degradation by the proteasome and its implications in aging. Review. Ann N Y Acad Sci 908 (2000) 143-154
29. Frisina R.D., Walton J.P., and Karcich K.J. Dorsal cochlear nucleus single neurons can enhance temporal processing capabilities in background noise. Exp Brain Res 102 1 (1994) 160-164
30. Frisina R.D. Subcortical neural coding mechanisms for auditory temporal processing. Review. Hear Res 158 1-2 (2001) 1-27
31. Fritschy J.M., Harvey R.J., and Schwarz G. Gephyrin: where do we stand, where do we go?. Trends Neurosci 31 5 (2008) 257-264
32. Frostholm A., and Rotter A. Glycine receptor distribution in mouse CNS: autoradiographic localization of [3H] strychnine binding sites. Brain Res Bull 15 5 (1985) 473-486
33. Frostholm A., and Rotter A. Autoradiographic localization of receptors in the cochlear nucleus of the mouse. Brain Res Bull 16 2 (1986) 189-203
34. Fukuoka T., Tokunaga A., Kondo E., Miki K., Tachibana T., and Noguchi K. Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model. Pain 78 1 (1998) 13-26
35. Glendenning K.K., and Baker B.N. Neuroanatomical distribution of receptors for three potential inhibitory neurotransmitters in the brainstem auditory nuclei of the cat. J Comp Neurol 275 2 (1988) 288-308
36. Grudzinska J., Schemm R., Haeger S., Nicke A., Schmalzing G., Betz H., and Laube B. The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45 5 (2005) 727-739
37. A receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging. Brain Res Mol Brain Res 45 1 (1997) 59-70
38. Hamann I., Gleich O., Klump G.M., Kittel M.C., and Strutz J. Age-dependent changes of gap detection in the Mongolian gerbil (Meriones unguiculatus). J Assoc Res Otolaryngol 5 (2004) 49-57
39. Huang X., Chen S., and Tietz E.I. Immunocytochemical detection of regional protein changes in rat brain sections using computer-assisted image analysis. J Histochem Cytochem 44 9 (1996) 981-987
40. Huang R., He S., Chen Z., Dillon G.H., and Leidenheimer N.J. Mechanisms of homomeric alpha1 glycine receptor endocytosis. Biochemistry 46 41 (2007) 11484-11493
41. Ingham N.J., Comis S.D., Withington D.J., Ingham N.J., Comis S.D., and Withington D.J. Hair cell loss in the aged guinea pig cochlea. Acta Otolaryngol 119 1 (1999) 42-47
42. Joris P.X., and Smith P.H. Temporal and binaural properties in dorsal cochlear nucleus and its output tract. J Neurosci 18 23 (1998) 10157-10170
43. Keithley E.M., and Feldman M.L. Spiral ganglion cell counts in an age-graded series of rat cochleas. J Comp Neurol 188 3 (1979) 429-442
44. Keithley E.M., and Feldman M.L. Hair cell counts in an age-graded series of rat cochleas. Hear Res 8 3 (1982) 249-262
45. Keithley E.M., Ryan A.F., and Woolf N.K. Spiral ganglion cell density in young and old gerbils. Hear Res 38 1-2 (1989) 125-133
46. Keithley E.M., and Croskrey K.L. Spiral ganglion cell endings in the cochlear nucleus of young and old rats. Hear Res 49 1-3 (1990) 169-177
47. Keithley E.M., Ryan A.F., and Feldman M.L. Cochlear degeneration in aged rats of four strains. Hear Res 59 2 (1992) 171-178
48. Keller J.N., Huang F.F., and Markesbery W.R. Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience 98 1 (2000) 149-156
49. Kiffin R., Kaushik S., Zeng M., Bandyopadhyay U., Zhang C., Massey A.C., Martinez-Vicente M., and Cuervo A.M. Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J Cell Sci 120 5 (2007) 782-791
50. Kirsch J., Wolters I., Triller A., and Betz H. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature 366 6457 (1993) 745-748
51. Kirsch J., and Betz H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392 6677 (1998) 717-720
52. Kirsch J. Glycinergic transmission. Review. Cell Tissue Res 326 2 (2006) 535-540
53. Kneussel M., Hermann A., Kirsch J., and Betz H. Hydrophobic interactions mediate binding of the glycine receptor beta-subunit to gephyrin. J Neurochem 72 3 (1999) 1323-1326
54. Kneussel M., and Betz H. Receptors, gephyrin and gephyrin-associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations. Review. J Physiol 525 1 (2000) 1-9
55. Kneussel M. Postsynaptic scaffold proteins at nonsynaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes. Review. EMBO Rep 6 1 (2005) 22-27
56. Kneussel M., and Loebrich S. Trafficking and synaptic anchoring of ionotropic inhibitory neurotransmitter receptors. Review. Biol Cell 99 6 (2007) 297-309
57. Kolston J., Osen K.K., Hackney C.M., Ottersen O.P., and Storm-Mathisen J. An atlas of glycine- and GABA-like immunoreactivity and colocalization in the cochlear nuclear complex of the guinea pig. Anat Embryol (Berl) 186 (1992) 443-465
58. Krenning J., Hughes L.F., Caspary D.M., and Helfert R.H. Age-related glycine receptor subunit changes in the cochlear nucleus of Fischer-344 rats. Laryngoscope 108 (1998) 26-31
59. Kujawa SJ, Liberman MC (2008) Noise-induced primary neuronal degeneration in ears with Complete threshold Recovery. In: Abstract 760 of the Association for Research in Otolaryngology (ARO) meeting 2008.
60. Langosch D., Becker C.M., and Betz H. The inhibitory glycine receptor: a ligand-gated chloride channel of the central nervous system. Eur J Biochem 194 1 (1990) 1-8
61. Legendre P. The glycinergic inhibitory synapse. Review. Cell Mol Life Sci 58 5-6 (2001) 760-793
62. Lévi S., Vannier C., and Triller A. Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J Cell Sci 111 Pt 3 (1998) 335-345
63. Ling L.L., Hughes L.F., and Caspary D.M. Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex. Neuroscience 132 4 (2005) 1103-1113
64. Lynch J.W. Molecular structure and function of the glycine receptor chloride channel. Review. Physiol Rev 84 4 (2004) 1051-1095
65. Maas C., Tagnaouti N., Loebrich S., Behrend B., Lappe-Siefke C., and Kneussel M. Neuronal cotransport of glycine receptor and the scaffold protein gephyrin. J Cell Biol 172 3 (2006) 441-451
66. Magnusson K.R., Nelson S.E., and Young A.B. Age-related changes in the protein expression of subunits of the NMDA receptor. Brain Res Mol Brain Res 99 1 (2002) 40-45
67. Malosio M.L., Marquèze-Pouey B., Kuhse J., and Betz H. Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J 10 9 (1991) 2401-2409
68. Massey A.C., Kiffin R., and Cuervo A.M. Autophagic defects in aging: looking for an "emergency exit"?. Cell Cycle 5 12 (2006) 1292-1296
69. May B.J. Role of the dorsal cochlear nucleus in the sound localization behavior of cats. Hear Res 148 1-2 (2000) 74-87
70. Mazurek B., Haupt H., Georgiewa P., Klapp B.F., and Reisshauer A. A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia. Med Hypotheses 67 4 (2006) 892-899
71. Meier J., Meunier-Durmort C., Forest C., Triller A., and Vannier C. Formation of glycine receptor clusters and their accumulation at synapses. J Cell Sci 113 Pt 15 (2000) 2783-2795
72. Milbrandt J.C., and Caspary D.M. Age-related reduction of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. Neuroscience 67 3 (1995) 713-719
73. A receptor subunit mRNA levels in the aging Fischer rat inferior colliculus. J Comp Neurol 379 3 (1997) 455-465
74. Moss S.J., and Smart T.G. Constructing inhibitory synapses. Review. Nat Rev Neurosci 2 4 (2001) 240-250
75. Nadol J.B. Electron microscopic findings in presbycusic degeneration of the basal turn of the human cochlea. Otolaryngol Head Neck Surg 87 (1979) 818-836
76. Ostroff J.M., McDonald K.L., Schneider B.A., and Alain C. Aging and the processing of sound duration in human auditory cortex. Hear Res 181 1-2 (2003) 1-7
77. Oertel D., and Young E.D. What's a cerebellar circuit doing in the auditory system?. Review. Trends Neurosci 27 2 (2004) 104-110
78. Otte J., Schunknecht H.F., and Kerr A.G. Ganglion cell populations in normal and pathological human cochleae. Implications for cochlear implantation. Laryngoscope 88 8 Pt 1 (1978) 1231-1246
79. Paloff A.M., and Usunoff K.G. Projections to the inferior colliculus from the dorsal column nuclei. An experimental electron microscopic study in the cat. J Hirnforsch 33 6 (1992) 597-610
80. Palombi P.S., and Caspary D.M. GABA inputs control discharge rate primarily within frequency receptive fields of inferior colliculus neurons. J Neurophysiol 75 6 (1996) 2211-2219
81. Pascale A., Amadio M., Govoni S., and Battaini F. The aging brain, a key target for the future: the protein kinase C involvement. Review. Pharmacol Rev 55 6 (2007) 560-569
82. Pichora-Fuller M.K., and Souza P.E. Effects of aging on auditory processing of speech. Review. Int J Audiol 42 Suppl 2 (2003) 2S11-2S16
83. Puel J.L., Ruel J., Guitton M., Wang J., and Pujol R. The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. Audiol Neurootol 7 1 (2002) 49-54
84. Pujol R., Rebillard G., Puel J.L., Lenoir M., Eybalin M., and Recasens M. Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing. Acta Otolaryngol Suppl 476 (1990) 32-36
85. Rattan S.I., Derventzi A., and Clark B.F. Protein synthesis, posttranslational modifications, and aging. Review. Ann N Y Acad Sci 663 (1992) 48-62
86. Rattan S.I. Synthesis, modifications, and turnover of proteins during aging. Review. Exp Gerontol 31 1-2 (1996) 33-47
87. Reiss L.A., and Young E.D. Spectral edge sensitivity in neural circuits of the dorsal cochlear nucleus. J Neurosci 25 14 (2005) 3680-3691
88. Rhode W.S., and Greenberg S. Encoding of amplitude modulation in the cochlear nucleus of the cat. J Neurophysiol 71 (1994) 1797-1825
89. Rhode W.S. Vertical cell responses to sound in cat dorsal cochlear nucleus. J Neurophysiol 82 (1999) 1019-1032
90. Rissman R.A., Nocera R., Fuller L.M., Kordower J.H., and Armstrong D.M. Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus. Brain Res 1073-1074 (2006) 120-130
91. Rissman R.A., De Blas A.L., and Armstrong D.M. GABA(A) receptors in aging and Alzheimer's disease. Review. J Neurochem 103 4 (2007) 1285-1292
92. Rose J.E., Galambos R., and Hughes J.R. Microelectrode studies of the cochlear nuclei of the cat. Bull Johns Hopkins Hosp 104 5 (1959) 211-251
93. Rose J.E., Galambos R., and Hughes J. Organization of frequency sensitive neurons in the cochlear nuclear complex of the cat. In: Rasmussan G.C., and Windle W.F. (Eds). Neuronal mechanisms of the auditory and vestibular systems (1960), Thomas Publishing, Springfield, IL 116-136
94. Rouiller E.M., Wan X.S., Moret V., and Liang F. Mapping of c-fos expression elicited by pure tones stimulation in the auditory pathways of the rat, with emphasis on the cochlear nucleus. Neurosci Lett 144 1-2 (1992) 19-24
95. Ryan A.F., Furlow Z., Woolf N.K., and Keithley E.M. The spatial representation of frequency in the rat dorsal cochlear nucleus and inferior colliculus. Hear Res 36 2-3 (1988) 181-189
96. Ryazanov A.G., and Nefsky B.S. Protein turnover plays a key role in aging. Review. Mech Ageing Dev 123 2-3 (2002) 207-213
97. Saint Marie R.L., Benson C.G., Ostapoff E.M., and Morest D.K. Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus. Hear Res 51 1 (1991) 11-28
98. Saint Marie R.L., Luo L., and Ryan A.F. Effects of stimulus frequency and intensity on c-fos mRNA expression in the adult rat auditory brainstem. J Comp Neurol 404 2 (1999) 258-270
99. Sato K., Kiyama H., and Tohyama M. Regional distribution of cells expressing glycine receptor alpha 2 subunit mRNA in the rat brain. Brain Res 590 1-2 (1992) 95-108
100. Schatteman T.A., Hughes L.F., and Caspary D.M. Aged-related loss of temporal processing: altered responses to amplitude modulated tones in rat dorsal cochlear nucleus. Neuroscience 154 1 (2008) 329-337
101. Schmieden V., and Betz H. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol 48 5 (1995) 919-927
102. Schneider B.A., Pichora-Fuller M.K., Kowalchuk D., and Lamb M. Gap detection and the precedence effect in young and old adults. J Acoust Soc Am 95 (1994) 980-991
103. Schrott A., Stephan K., and Spoendlin H. Auditory brainstem response thresholds in a mouse mutant with selective outer hair cell loss. Eur Arch Otorhinolaryngol 247 1 (1990) 8-11
104. Snell K.B. Age-related changes in temporal gap detection. J Acoust Soc Am 101 (1997) 2214-2220
105. Spirou G.A., Davis K.A., Nelken I., and Young E.D. Spectral integration by type II interneurons in dorsal cochlear nucleus. J Neurophysiol 82 2 (1999) 648-663
106. Spoendlin H., and Schrott A. The spiral ganglion and the innervation of the human organ of Corti. Acta Otolaryngol 105 5-6 (1988) 403-410
107. Spongr V.P., Flood D.G., Frisina R.D., and Salvi R.J. Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans. J Acoust Soc Am 101 6 (1997) 3546-3553
108. Stamataki S., Francis H.W., Lehar M., May B.J., and Ryugo D.K. Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice. Hear Res 221 1-2 (2006) 104-118
109. Sutherland D.P., Glendenning K.K., and Masterton R.B. Role of acoustic striae in hearing: discrimination of sound-source elevation. Hear Res 120 1-2 (1998) 86-108
110. Syka J., Rybalko N., Mazelova J., and Druga R. Gap detection threshold in the rat before and after auditory cortex ablation. Hear Res 172 (2002) 151-159
111. Tremblay K.L., Piskosz M., and Souza P. Aging alters the neural representation of speech cues. Neuroreport 13 (2002) 1865-1870
112. Tremblay K.L., Piskosz M., and Souza P. Effects of age and age-related hearing loss on the neural representation of speech cues. Clin Neurophysiol 114 7 (2003) 1332-1343
113. Turner J.G., Brozoski T.J., Bauer C.A., Parrish J.L., Myers K., Hughes L.F., and Caspary D.M. Gap detection deficits in rats with tinnitus: a potential novel screening tool. Behav Neurosci 120 1 (2006) 188-195
114. Turner J.G., and Caspary D.M. Comparision of two rat models of aging. In: Syka J., and Merzenich M.M. (Eds). Plasticity and signal representation in the auditory system (2005), Springer, New York 217-225
115. Vela J., Gutierrez A., Vitorica J., and Ruano D. Rat hippocampal GABAergic molecular markers are differentially affected by ageing. J Neurochem 85 2 (2003) 368-377
116. Voigt H.F., and Young E.D. Evidence of inhibitory interactions between neurons in dorsal cochlear nucleus. J Neurophysiol 44 1 (1980) 76-96
117. Voigt H.F., and Young E.D. Cross-correlation analysis of inhibitory interactions in dorsal cochlear nucleus. J Neurophysiol 64 5 (1990) 1590-1610
118. Walton J.P., Frisina R.D., Ison J.R., and O'Neill W.E. Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse. J Comp Physiol 181 (1997) 161-176
119. Walton J.P., Frisina R.D., and O'Neill W.E. Age-related alteration in processing of temporal sound features in the auditory midbrain of the CBA mouse. J Neurosci 18 7 (1998) 2764-2776
120. Wickesberg R.E., and Oertel D. Tonotopic projection from the dorsal to the anteroventral cochlear nucleus of mice. J Comp Neurol 268 3 (1988) 389-399
121. Willott J.F., Milbrandt J.C., Bross L.S., and Caspary D.M. Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochlear impairment and aging. J Comp Neurol 385 (1997) 405-414
122. Willott J.F., and Turner J.G. Prolonged exposure to an augmented acoustic environment ameliorates age-related auditory changes in C57BL/6J and DBA/2J mice. Hear Res 135 1-2 (1999) 78-88
123. Yajima Y., and Hayashi Y. Response properties and tonotopical organization in the dorsal cochlear nucleus in rats. Exp Brain Res 75 2 (1989) 381-389
124. Young A.B., and Snyder S.H. Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A 70 10 (1973) 2832-2836
125. Young A.B., and Snyder S.H. The glycine synaptic receptor: evidence that strychnine binding is associated with the ionic conductance mechanism. Proc Natl Acad Sci U S A 71 10 (1974) 4002-4005
126. Zhang S., and Oertel D. Neuronal circuits associated with the output of the dorsal cochlear nucleus through fusiform cells. J Neurophysiol 71 3 (1994) 914-930