Postsynaptic scaffold proteins at non-synaptic sites: The role of postsynaptic scaffold proteins in motor-protein-receptor complexes

EMBO Reports

Volumn 6, Issue 1, 2005, Pages 22-27

  Kneussel, Matthias ^a,b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Motor protein; Neurotransmitter receptor; Postsynaptic density; Synapse; Transport

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACTIN BINDING PROTEIN; ADAPTOR PROTEIN; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DYNEIN ADENOSINE TRIPHOSPHATASE; GEPHYRIN; GLUTAMATE RECEPTOR 1; GLYCINE RECEPTOR; KAINIC ACID RECEPTOR; KINESIN; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MOLECULAR MOTOR; MYOSIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROTRANSMITTER RECEPTOR; NUCLEAR RECEPTOR COACTIVATOR 2; PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; REGULATOR PROTEIN; SCAFFOLD PROTEIN;

CELL MEMBRANE; INTRACELLULAR TRANSPORT; MICROFILAMENT; MICROTUBULE; NERVE CELL; NONHUMAN; PLASTICITY; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; SYNAPTIC TRANSMISSION; ANIMAL; CHEMISTRY; METABOLISM; SYNAPSE;

ANIMALS; MICROTUBULES; NEURONS; PROTEIN TRANSPORT; SYNAPSES;

EID: 21444447912     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400319     Document Type: Review

References (35)

1. Ashby MC, De La Rue SA, Ralph GS, Uney J, Collingridge GL, Henley JM (2004) Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. J Neurosci 24: 5172-5176
2. Baas PW, Deitch JS, Black MM, Banker GA (1988) Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci USA 85: 8335-8339
3. Choquet D, Triller A (2003) The role of receptor diffusion in the organization of the postsynaptic membrane. Nat Rev Neurosci 4: 251-265
4. Christensen El, Birn H (2002) Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 3: 256-266
5. Dong H, Zhang P, Liao D, Huganir RL (1999) Characterization, expression, and distribution of GRIP protein. Ann NY Acad Sci 868: 535-540
6. Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M (2002) Gephyrin interacts with dynein light chains 1 and 2, components of motor protein complexes. J Neurosci 22: 5393-5402
7. Greger IH, Khatri L, Ziff EB (2002) RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum. Neuron 34: 759-772
8. Guillaud L, Setou M, Hirokawa N (2003) KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci 23: 131-140
9. Hanus C, Vannier C, Triller A (2004) Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate. J Neurosci 24: 1119-1128
10. Hasson T (2003) Myosin VI: two distinct roles in endocytosis. J Cell Sci 116: 3453-3461
11. Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci 3: 661-669
12. Jakowec MW, Yen L, Kalb RG (1995) In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67: 909-920
13. Kanai Y, Okada Y, Janaka Y, Harada A, Terada S, Hirokawa N (2000) KIF5C, a novel neuronal kinesin enriched in motor neurons. J Neurosci 20: 6374-6384
14. Kittler JT, Rostaing P, Schiavo G, Fritschy JM, Olsen R, Triller A, Moss SJ (2001) The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors. Mol Cell Neurosci 18: 13-25
15. Klopfenstein DR, Vale RD, Rogers SL (2000) Motor protein receptors: moonlighting on other jobs. Cell 103: 537-540
16. Kneussel M, Betz H (2000) Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci 23: 429-435
17. Kneussel M, Haverkamp S, Fuhrmann JC, Wang H, Wassle H, Olsen RW, Betz H (2000) The γ-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci USA 97: 8594-8599
18. Lee SH, Liu L, Wang YT, Sheng M (2002) Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36: 661-674
19. Meier J, Meunier-Durmort C, Forest C, Triller A, Vannier C (2000) Formation of glycine receptor clusters and their accumulation at synapses. J Cell Sci 113: 2783-2795
20. Mok H, Shin H, Kim S, Lee JR, Yoon J, Kim E (2002) Association of the kinesin superfamily motor protein KIF1 Bα with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci 22: 5253-5258
21. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (2000) Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci 20: 4524-4534
22. Nakata T, Hirokawa N (2003) Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. J Cell Biol 162: 1045-1055
23. Peng J, Kim MJ, Cheng D, Duong DM, Gygi SP, Sheng M (2004) Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. J Biol Chem 279: 21003-21011
24. Petralia RS, Wenthold RJ (1992) Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J Comp Neurol 318: 329-354
25. Petralia RS, Wang YX, Wenthold RJ (2003) Internalization at glutamatergic synapses during development. Eur J Neurosci 18: 3207-3217
26. Rao A, Kim E, Sheng M, Craig AM (1998) Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. J Neurosci 18: 1217-1229
27. Rao A, Cha EM, Craig AM (2000) Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neurons. J Neurosci 20: 8344-8353
28. Setou M, Nakagawa T, Seog DH, Hirokawa N (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288: 1796-1802
29. Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N (2002) Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature 417: 83-87
30. Sheng M (2001) Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci USA 98: 7058-7061
31. Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS (2003) Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol 161: 805-816
32. Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19: 4180-4188
33. Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (1999) GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature 397: 69-72
34. Wong RW, Setou M, Teng J, Takei Y, Hirokawa N (2002) Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA 99: 14500-14505
35. Wu H, Nash JE, Zamorano P, Garner CC (2002) Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking. J Biol Chem 277: 30928-30934