Regulation of murine airway eosinophilia and Th2 cells by antigen- conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator

Journal of Immunology

Volumn 164, Issue 11, 2000, Pages 5575-5582

  Shirota, Hidekazu ^a   Sano, Kunio ^a   Kikuchi, Tadashi ^a   Tamura, Gen ^a   Shirato, Kunio ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EOSINOPHILIA; IMMUNOMODULATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY TRACT DISEASE; TH2 CELL;

EID: 0034090116     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.5575     Document Type: Article

References (48)

1. Tada, T. 1984. Help, suppression, and specific factors. In Fundamental Immunology. W. E. Paul, ed. Raven Press, New York, p. 481.
2. Mitchison, N. A. 1971. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation. Eur. J. Immunol. 1:18.
3. d. Proc. Natl. Acad. Sci. USA 81:7564.
4. + T cells. Nature 401:76.
5. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A. J. Wardlaw, C. J. Corrigan, B. Bradley, S. R. Durham, J. V. Collins, P. K. Jeffery, et al. 1991. Expression of mRNA for IL-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87: 1541.
6. Walker, C., J. C. Virchow, Jr., P. L. Bruijnzeel, and K. Blaser. 1991. T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J. Immunol. 146:1829.
7. Bradley, B. L., M. Azzawi, M. Jacobson, B. Assoufi, J. V. Collins, A. M. Irani, L. B. Schwartz, S. R. Durham, P. K. Jeffery, and A. B. Kay. 1991. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 88:661.
8. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
9. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J. C. Virchow, Jr. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 145:109.
10. Haneda, K., K. Sano, G. Tamura, T. Sato, S. Habu, and K. Shirato. 1997. TGF-β induced by oral tolerance ameliorates experimental tracheal eosinophilia. J. Immunol. 159:4484.
11. Sano, K., K. Haneda, G. Tamura, and K. Shirato. 1999. Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia. Am. J. Respir. Mol. Cell Biol. 20:1260.
12. + T cells ameliorates antigen-induced eosinophilic inflammation: novel high-dose tolerance in the trachea. Am. J. Respir. Cell Mol. Biol. 21:268.
13. Shirota, H., K. Sano, T. Kikuchi, G. Tamura, and K. Shirato. 2000. Regulation of T-helper cell type 2 and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am. J. Respir. Cell Mol. Biol. 22:176.
14. Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete IL-6, IL-12, and IFN-γ. Proc. Natl. Acad. Sci. USA 93:2879.
15. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
16. Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623.
17. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185.
18. Lipford, G. B., M. Bauer, C. Blank, R. Reiter, H. Wagner, and K. Heeg. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:2340.
19. Weiner, G. J., H. M. Liu, J. E. Wooldridge, C. E. Dahle, and A. M. Krieg. 1997. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 94:10833.
20. Jakob, T., P. S. Walker, A. M. Krieg, M. C. Udey, and J. C. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 3042.
21. Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627.
22. Sun, S., H. Kishimoto, and J. Sprent, 1998. DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J. Exp. Med. 187:1145.
23. Sparwasser, T., E. S. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, J. W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045.
24. Cowdery, J. S., J. H. Chace, A. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570.
25. Sarmiento, U. M., J. R. Perez, J. M. Becker, and R. Narayanan. 1994. In vivo toxicological effects of Rel A antisense phosphorothioates in CD-1 mice. Antisense Res. Dev. 4:99.
26. Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Häcker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336.
27. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of TNF-α-mediated shock. Eur. J. Immunol. 27:1671.
28. Broide, D., J. Schwarze, H. Tighe, T. Gifford, M. Nguyen, S. Malek, J. V. Uden, E. Martin-Orozco, E. W. Gelfand, and E. Raz. 1998. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J. Immunol. 161:7054.
29. Sur, S., J. S. Wild, B. K. Choudhury, N. Sur, R. Alam, and D. M. Klinman. 1999. Long-term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 162:6284.
30. Sato, T., T. Sasahara, Y. Nakamura, T. Osaki, T. Hasegawa, T. Tadakuma, Y. Arata, Y. Kumagai, M. Katsuki, and S. Habu. 1994. Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur. J. Immunol. 24:1512.
31. Mead, J., and J. L. Whittenberger. 1953. Physical properties of human lungs measured during spontaneous respiration. J. Appl. Physiol. 5:779.
32. Wilde, D. B., P. Marrack, J. Kappler, D. P. Dialynas, and F.W. Fitch. 1983. Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1. 5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J. Immunol. 131:2178.
33. Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
34. Doerfler W. 1991. Patterns of DNA methylation-evolutionary vestiges of foreign DNA inactivation as a host defense mechanism: a proposal. Biol. Chem. Hoppe-Seyler 372:557.
35. Krieg, A. M., A. K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
36. Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of natural killer activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840.
37. Kline, J. N., T. J. Waldschmidt, T. R. Businga, J. E. Lemish, J. V. Weinstock, P. S. Thorne, and A. M. Krieg. 1998. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160:2555.
38. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34.
39. Krieg, A. M. CpG DNA: a pathogenic factor in systemic lupus erythematosus? 1995. J. Clin. Immunol. 15:284.
40. Gilkeson, G. S., P. Ruiz, A. M. M. Pippen, A. L. Alexander, J. B. Lefkowith, and D. S. Pisetsky. 1996. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. J. Exp. Med. 183:1389.
41. Mor, G., M. Singla, A. D. Steinberg, S. L. Hoffman, K. Okuda, and D. M. Klinman. 1997. Do DNA vaccines induce autoimmune disease? Hum. Gene Ther. 8:293.
42. Tsunoda, I., N. D. Tolley, D. J. Theil, J. L. Whitton, H. Kobayashi, and R. S. Fujinami. 1999. Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA. Brain Pathol. 9:481.
43. Schwartz, D. A., T. J. Quinn, P. S. Thorne, S. Sayeed, A. K. Yi, and A. M. Krieg. 1997. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract. J. Clin. Invest. 100:68.
44. Deng, G. M., I. M. Nilsson, M. Verdrengh, L. V. Collins, and A. Tarkowski. 1999. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat. Med. 5:702.
45. Desai, D., M. Krishnan, J. Swindle, and T. Marion. 1993. Antigen specific induction of antibodies against native mammalian DNA in non-autoimmune mice. J. Immunol. 151:1614.
46. Gilkeson, G. S., A. M. Pippen, and D. S. Pisetsky. 1995. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J. Clin. Invest. 95:1398.
47. Rekvig, O. P., U. Moens, A. Sundsfjord, G. Bredholt, A. Osei, H. Haaheim, T. Traavik, E. Arnesen, and H. J. Haga. 1997. Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen: a molecular basis for induction of antibodies to DNA and eukaryotic transcription factors. J. Clin. Invest. 99:2045.
48. Gilkeson, G. S., P. Ruiz, A. M. M. Pippen, A. L. Alexander, J. B. Lefkowith, and D. S. Pisetsky. 1996. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. J. Exp. Med. 183:1389.