3,4-dihydroxypyrrolidine as glycosidase inhibitor

Current Topics in Medicinal Chemistry

Volumn 9, Issue 1, 2009, Pages 34-57

  Suzuki, Katsuhiko ^a   Nakahara, Tatsuto ^b   Kanie, Osamu ^a,b  

^a MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Azasugar; Conformational change; Glycosidase; Imino sugar; Inhibitor; Pyrrolidine; Transition

Indexed keywords

1 DEOXYNOJIRIMYCIN; 3,4 DIHYDROXYPYRROLIDINE DERIVATIVE; ALPHA GALACTOSIDASE; ALPHA GLUCOSIDASE; ALPHA LEVO FUCOSIDASE; ALPHA MANNOSIDASE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; GALACTOSIDASE; GALACTOSIDASE INHIBITOR; GALACTOSTATIN; GLUCOSIDASE; GLYCOSIDASE INHIBITOR; IMINOSUGAR; MANNOSIDASE; PYRROLIDINE DERIVATIVE; SWAINSONINE; UNCLASSIFIED DRUG;

COLON CANCER; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DIABETES MELLITUS; DIAGNOSTIC VALUE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SPECIFICITY; FABRY DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIVER CELL CARCINOMA; LYSOSOME STORAGE DISEASE; METASTASIS; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GALACTOSIDASES; GLYCOSIDE HYDROLASES; IMINO SUGARS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 63249126630     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802609787354315     Document Type: Review

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