Polyhydroxylated alkaloids - Natural occurrence and therapeutic applications

Phytochemistry

Volumn 56, Issue 3, 2001, Pages 265-295

  Watson, Alison A ^a   Fleet, George W J ^b   Asano, Naoki ^c   Molyneux, Russell J ^d   Nash, Robert J ^e  

^a Molecular Nature Ltd   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HOKURIKU UNIVERSITY   (Japan)

^d WESTERN REGIONAL RESEARCH CENTER   (United States)

^e ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Glycosidase; Indolizidines; Inhibitors; N Containing sugars; Nortropanes; Piperidines; Pyrrolidines; Pyrrolizidines

Indexed keywords

1 DEOXYNOJIRIMYCIN; 2,6 DIDEOXY 2,6 IMINO 7 O BETA D GLUCOPYRANOSYL D GLYCERO L GULO HEPTITOL; ALKALOID; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CASTANOSPERMINE; ENZYME INHIBITOR; FAGOMINE; GD 0039; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; GLYCOSPHINGOLIPID; IMMUNOSTIMULATING AGENT; MIGLITOL; NECTRISINE; PYRROLIDINE DERIVATIVE; PYRROLINE DERIVATIVE; SWAINSONINE; UNCLASSIFIED DRUG;

ANIMAL; ANTINEOPLASTIC ACTIVITY; AUTOIMMUNE DISEASE; CARBOHYDRATE METABOLISM; CLINICAL TRIAL; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; DRUG ISOLATION; DRUG MECHANISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYSOSOME STORAGE DISEASE; NONHUMAN; REVIEW; TOXICITY TESTING; VIRUS INFECTION;

ALKALOIDS; ANIMALS; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; TOXICITY TESTS;

EID: 0035925104     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(00)00451-9     Document Type: Article

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208. Castanospermine and other plant alkaloid inhibitors of glucosidase activity block the growth of HIV
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210. Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta
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213. Inhibition of adjuvant arthritis in the rat by phosphosugars and the α-glucosidase inhibitor castanospermine
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221. Configurational and conformational analysis of highly oxygenated pyrrolizidines: Definitive identification of some naturally occurring 7α-epi-alexines
222. Inhibition of human ovarian carcinoma cell- and hexosamininidase-mediated degradation of extracellular matrix by sugar analogs
223. The structure of moranoline, a piperidine alkaloid from Morus species
224. Swainsonine an inhibitor of glycoprotein processing enhances cytotoxicity of large granular lymphocytes
225. Homonojirimycin and N-methyl α-homonojirimycin inhibit N-linked oligosaccharide processing