Inhibition of heme synthesis alters Amyloid Precursor Protein processing

Journal of Neural Transmission

Volumn 116, Issue 1, 2009, Pages 79-88

  Gatta, Luisa Benerini ^a   Vitali, Massimiliano ^a   Verardi, Rosanna ^b   Arosio, Paolo ^a,c   Finazzi, Dario ^a,c  

^a UNIVERSITY OF BRESCIA   (Italy)

^b Servizio di Immunoematologia e Medicina Trasfusionale   (Italy)

^c Spedali Civili di Brescia   (Italy)

Author keywords

Alzheimer's disease; Amyloid ; Ferrochelatase; Heme; Mitochondria; N Methylprotoporphyrin; Oxidative stress

Indexed keywords

ADAM 10 PROTEIN; ADAM PROTEIN; ADENOSINE TRIPHOSPHATE; ALPHA SECRETASE; AMYLOID A PROTEIN; AMYLOID BETA PROTEIN[25-35]; AMYLOID PRECURSOR PROTEIN; CHLOROTRIANISENE; CYTOCHROME C OXIDASE; FERROCHELATASE; HEME; N METHYLPROTOPORPHYRIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENERGY YIELD; HEME SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING;

ADAM PROTEINS; ADENOSINE TRIPHOSPHATE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; FERROCHELATASE; HEME; HUMANS; MEMBRANE PROTEINS; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PHYSIOLOGICAL PROCESSES; PROTEIN CARBONYLATION; PROTOPORPHYRINS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 62949207781     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-008-0147-z     Document Type: Article

References (44)

1. S Afonso G Vanore A Batlle 1999 Protoporphyrin IX and oxidative stress Free Radic Res 31 3 161 170
2. H Atamna WH Frey 2nd 2004 A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism Proc Natl Acad Sci USA 101 30 11153 11158
3. H Atamna K Boyle 2006 Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease Proc Natl Acad Sci USA 103 9 3381 3386
4. H Atamna WH Frey 2nd 2007 Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease Mitochondrion 7 5 297 310
5. H Atamna J Liu BN Ames 2001 Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: relevance to aging J Biol Chem 276 51 48410 48416
6. H Atamna DW Killilea AN Killilea BN Ames 2002 Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging Proc Natl Acad Sci USA 99 23 14807 14812
7. M Bentahir O Nyabi J Verhamme A Tolia K Horre J Wiltfang H Esselmann B De Strooper 2006 Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms J Neurochem 96 3 732 742
8. L Bertram RE Tanzi 2004 The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacol Res 50 4 385 396
9. M Bitar M Weiner 1983 Modification of age-induced changes in heme and hemoproteins by testosterone in male rats Mech Ageing Dev 23 3-4 285 296
10. H Brunner F Hausmann RC Krieg E Endlicher J Scholmerich R Knuechel H Messmann 2001 The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines Photochem Photobiol 74 5 721 725
11. DA Butterfield HF Poon D St Clair JN Keller WM Pierce JB Klein WR Markesbery 2006 Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease Neurobiol Dis 22 2 223 232
12. T Chernova P Nicotera AG Smith 2006 Heme deficiency is associated with senescence and causes suppression of N-methyl-d-aspartate receptor subunits expression in primary cortical neurons Mol Pharmacol 69 3 697 705
13. MJ de Leon AE George 1983 Computed tomography in aging and senile dementia of the Alzheimer type Adv Neurol 38 103 122
14. BE Dwyer ML Stone X Zhu G Perry MA Smith 2006 Heme deficiency in Alzheimer's disease: a possible connection to porphyria J Biomed Biotechnol 3 24038 24042
15. JT Gamble HA Dailey GS Marks 2000 N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase Drug Metab Dispos 28 4 373 375
16. GE Gibson KF Sheu JP Blass 1998 Abnormalities of mitochondrial enzymes in Alzheimer disease J Neural Transm 105 8-9 855 870
17. TE Golde D Dickson M Hutton 2006 Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease Curr Alzheimer Res 3 5 421 430
18. J Hardy D Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 5580 353 356
19. D Howlett P Cutler S Heales P Camilleri 1997 Hemin and related porphyrins inhibit beta-amyloid aggregation FEBS Lett 417 2 249 251
20. A Hoyer HJ Bardenheuer E Martin K Plaschke 2005 Amyloid precursor protein (APP) and its derivatives change after cellular energy depletion. An in vitro-study J Neural Transm 112 2 239 253
21. JM Jacobs PR Sinclair JF Sinclair N Gorman HS Walton SG Wood C Nichols 1998 Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead Toxicology 125 2-3 95 105
22. JN Keller FA Schmitt SW Scheff Q Ding Q Chen DA Butterfield WR Markesbery 2005 Evidence of increased oxidative damage in subjects with mild cognitive impairment Neurology 64 7 1152 1156
23. S Kumar-Singh J Theuns B Van Broeck D Pirici K Vennekens E Corsmit M Cruts B Dermaut R Wang C Van Broeckhoven 2006 Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40 Hum Mutat 27 7 686 695
24. PN Lacor MC Buniel L Chang SJ Fernandez Y Gong KL Viola MP Lambert PT Velasco EH Bigio CE Finch GA Krafft WL Klein 2004 Synaptic targeting by Alzheimer's-related amyloid beta oligomers J Neurosci 24 45 10191 10200
25. MP Lambert AK Barlow BA Chromy C Edwards R Freed M Liosatos TE Morgan I Rozovsky B Trommer KL Viola P Wals C Zhang CE Finch GA Krafft WL Klein 1998 Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins Proc Natl Acad Sci USA 95 11 6448 6453
26. A Lloret MC Badía NJ Mora A Ortega FV Pallardó MD Alonso H Atamna J Viña 2008 Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease Free Radic Biol Med 44 12 2019 2025
27. WR Markesbery MA Lovell 1998 Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease Neurobiol Aging 19 1 33 36
28. EM Mutisya AC Bowling MF Beal 1994 Cortical cytochrome oxidase activity is reduced in Alzheimer's disease J Neurochem 63 6 2179 2184
29. WJ Netzer F Dou D Cai D Veach S Jean Y Li WG Bornmann B Clarkson H Xu P Greengard 2003 Gleevec inhibits beta-amyloid production but not Notch cleavage Proc Natl Acad Sci USA 100 21 12444 12449
30. J Nunan DH Small 2000 Regulation of APP cleavage by alpha-, beta- and gamma-secretases FEBS Lett 483 1 6 10
31. A Nunomura S Chiba CF Lippa P Cras RN Kalaria A Takeda K Honda MA Smith G Perry 2004 Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease Neurobiol Dis 17 1 108 113
32. D Pratico CM Clark F Liun J Rokach VY Lee JQ Trojanowski 2002 Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease Arch Neurol 59 6 972 976
33. H Reichmann S Florke G Hebenstreit H Schrubar P Riederer 1993 Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease J Neurol 240 6 377 380
34. C Richter V Gogvadze R Laffranchi R Schlapbach M Schweizer M Suter P Walter M Yaffee 1995 Oxidants in mitochondria: from physiology to diseases Biochim Biophys Acta 1271 1 67 74
35. S Scheuermann B Hambsch L Hesse J Stumm C Schmidt D Beher TA Bayer K Beyreuther G Multhaup 2001 Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease J Biol Chem 276 36 33923 33929
36. DM Skovronsky DB Moore ME Milla RW Doms VM Lee 2000 Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network J Biol Chem 275 4 2568 2575
37. CD Smith JM Carney PE Starke-Reed CN Oliver ER Stadtman RA Floyd WR Markesbery 1991 Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease Proc Natl Acad Sci USA 88 23 10540 10543
38. RS Sohal 1993 Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria Free Radic Biol Med 14 6 583 588
39. R Sultana HF Poon J Cai WM Pierce M Merchant JB Klein WR Markesbery DA Butterfield 2006 Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach Neurobiol Dis 22 1 76 87
40. E Tamagno P Bardini A Obbili A Vitali R Borghi D Zaccheo MA Pronzato O Danni MA Smith G Perry M Tabaton 2002 Oxidative stress increases expression and activity of BACE in NT2 neurons Neurobiol Dis 10 3 279 288
41. Y Tong W Zhou V Fung MA Christensen H Qing X Sun W Song 2005 Oxidative stress potentiates BACE1 gene expression and Abeta generation J Neural Transm 112 3 455 469
42. RA Velliquette T O'Connor R Vassar 2005 Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis J Neurosci 25 47 10874 10883
43. DM Walsh I Klyubin JV Fadeeva MJ Rowan DJ Selkoe 2002 Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition Biochem Soc Trans 30 4 552 557
44. A Wielburski BD Nelson 1994 Heme a induces assembly of rat liver cytochrome c oxidase subunits I-III in isolated mitochondria FEBS Lett 177 2 291 294