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Volumn 23, Issue 2, 2009, Pages 149-157

Neuromedin U: Physiology, pharmacology and therapeutic potential

Author keywords

Neuromedin U; Neuropeptide; NmU R1; NmU R2

Indexed keywords

NEUROMEDIN U;

EID: 62849094751     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2009.00667.x     Document Type: Review
Times cited : (47)

References (74)
  • 1
    • 0022249076 scopus 로고
    • Neuromedin U 8 and neuromedin U25 novel uterus stimulating and hypertensive peptides identified in porcine spinal cord
    • Minamino N., Kangawa K., Matsuo H. Neuromedin U 8 and neuromedin U25 novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem. Biophys. Res. Commun. (1985) 130 1078 1085.
    • (1985) Biochem. Biophys. Res. Commun. , vol.130 , pp. 1078-1085
    • Minamino, N.1    Kangawa, K.2    Matsuo, H.3
  • 2
    • 0034805457 scopus 로고    scopus 로고
    • Evolution of vertebrate neuropeptides
    • Holmgren S., Jensen J. Evolution of vertebrate neuropeptides. Brain Res. Bull. (2001) 55 723 735.
    • (2001) Brain Res. Bull. , vol.55 , pp. 723-735
    • Holmgren, S.1    Jensen, J.2
  • 3
    • 0028923630 scopus 로고
    • Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract
    • Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. J. Mol. Endocrinal. (1995) 14 157 169.
    • (1995) J. Mol. Endocrinal. , vol.14 , pp. 157-169
    • Austin, C.1    Lo, G.2    Nandha, K.A.3    Meleagros, L.4    Bloom, S.R.5
  • 4
    • 0023405198 scopus 로고
    • NmU - A study of its distribution in the rat
    • Domin J., Ghatei M.A., Chohan P., Bloom S.R. NmU - A study of its distribution in the rat. Peptides (1987) 8 779 784.
    • (1987) Peptides , vol.8 , pp. 779-784
    • Domin, J.1    Ghatei, M.A.2    Chohan, P.3    Bloom, S.R.4
  • 5
    • 2642553111 scopus 로고    scopus 로고
    • Neuromedin U and its receptors: Structure, function, and physiological roles
    • Brighton P.J., Szekeres P.G., Willars G.B. Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol. Rev. (2004) 56 231 248.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 231-248
    • Brighton, P.J.1    Szekeres, P.G.2    Willars, G.B.3
  • 6
    • 0034671543 scopus 로고    scopus 로고
    • Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
    • Shan L., Qiao X., Crona J.H. et al. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. J. Biol. Chem. (2000) 275 39482 39486.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39482-39486
    • Shan, L.1    Qiao, X.2    Crona, J.H.3
  • 7
    • 0034693142 scopus 로고    scopus 로고
    • Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
    • Raddatz R., Wilson A.E., Artymyshyn R. et al. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J. Biol. Chem. (2000) 275 32452 32459.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32452-32459
    • Raddatz, R.1    Wilson, A.E.2    Artymyshyn, R.3
  • 9
    • 0033798358 scopus 로고    scopus 로고
    • Identificationof a human gastrointestinal tract and immune system receptor for the peptide neuromedin U
    • Hedrick J.A., Morse K., Shan L. et al. Identificationof a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol. Pharmacol. (2000) 58 870 875.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 870-875
    • Hedrick, J.A.1    Morse, K.2    Shan, L.3
  • 10
    • 0034647902 scopus 로고    scopus 로고
    • Identification of neuromedin U as the cognate ligands of the orphans G protein coupled receptor FM3
    • Fujii R., Hosoya M., Fukusumi S. et al. Identification of neuromedin U as the cognate ligands of the orphans G protein coupled receptor FM3. J. Biol. Chem. (2000) 275 21068 21074.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21068-21074
    • Fujii, R.1    Hosoya, M.2    Fukusumi, S.3
  • 11
    • 2642526577 scopus 로고    scopus 로고
    • Characterisation of signaling by recombinant human neuromedin U receptors
    • Brighton P.J., Szekeres P.G., Aiyar N., Willars G.B. Characterisation of signaling by recombinant human neuromedin U receptors. Br. J. Pharmacol. (2003) 140 75P.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 75
    • Brighton, P.J.1    Szekeres, P.G.2    Aiyar, N.3    Willars, G.B.4
  • 12
    • 24344453402 scopus 로고    scopus 로고
    • Screening of active compounds as neuromedin U2 receptor agonist from natural products
    • Zheng X., Hu Y., Liu J., Ouyang K. Screening of active compounds as neuromedin U2 receptor agonist from natural products. Bioorg. Med. Chem. Lett. (2005) 15 4531 4535.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4531-4535
    • Zheng, X.1    Hu, Y.2    Liu, J.3    Ouyang, K.4
  • 13
    • 20144385882 scopus 로고    scopus 로고
    • Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima
    • Lee W.H., Liu S.B., Shen J.H., Jin Y., Lai R., Zhang Y. Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima. Regul. Pept. (2005) 129 43 47.
    • (2005) Regul. Pept. , vol.129 , pp. 43-47
    • Lee, W.H.1    Liu, S.B.2    Shen, J.H.3    Jin, Y.4    Lai, R.5    Zhang, Y.6
  • 14
    • 0034681357 scopus 로고    scopus 로고
    • Isolation, structural characterization, and bioactivity of a novel neuromedin U analog from the defensive skin secretion of the Australasian tree frog, Litoria caerulea
    • Salmon A.L., Johnsen A.H., Bienert M. et al. Isolation, structural characterization, and bioactivity of a novel neuromedin U analog from the defensive skin secretion of the Australasian tree frog, Litoria caerulea. J. Biol. Chem. (2000) 275 4549 4554.
    • (2000) J. Biol. Chem. , vol.275 , pp. 4549-4554
    • Salmon, A.L.1    Johnsen, A.H.2    Bienert, M.3
  • 15
    • 0141923484 scopus 로고    scopus 로고
    • Pro-nociceptive effects of neuromedin U in rat
    • Yu X.H., Cao C.Q., Mennicken F. et al. Pro-nociceptive effects of neuromedin U in rat. Neuroscience (2003) 120 467 474.
    • (2003) Neuroscience , vol.120 , pp. 467-474
    • Yu, X.H.1    Cao, C.Q.2    Mennicken, F.3
  • 16
    • 62849108123 scopus 로고    scopus 로고
    • Hawthorn, J., Redmond, K. Blackwell Publishing, USA, pp.
    • Hawthorn J., Redmond K. Pain Causes & Management, Blackwell Publishing, USA, 1998, pp. 7 29.
    • (1998) Pain Causes & Management , pp. 7-29
  • 17
    • 4644242533 scopus 로고    scopus 로고
    • Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones
    • Moriyama M., Furue H., Katafuchi T., Teranishi H., Sato T., Kano T. Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones. J. Physiol. (2004) 559 707 713.
    • (2004) J. Physiol. , vol.559 , pp. 707-713
    • Moriyama, M.1    Furue, H.2    Katafuchi, T.3    Teranishi, H.4    Sato, T.5    Kano, T.6
  • 18
    • 33646539175 scopus 로고    scopus 로고
    • The neuropeptide neuromedin U activates eosinophils and is involved in allergen induced eosinophilia
    • Moriyama M., Fukuyama S., Inoue H. et al. The neuropeptide neuromedin U activates eosinophils and is involved in allergen induced eosinophilia. Am. J. Physiol. Lung Cell. Mol. Physiol. (2006) 290 L971 L977.
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.290
    • Moriyama, M.1    Fukuyama, S.2    Inoue, H.3
  • 19
    • 0141887005 scopus 로고    scopus 로고
    • A pronociception role of neuromedin U in adult mice
    • Cao C.Q., Yu X.H., Dray A., Filosa A., Perkins M.N. A pronociception role of neuromedin U in adult mice. Pain (2003) 104 609 616.
    • (2003) Pain , vol.104 , pp. 609-616
    • Cao, C.Q.1    Yu, X.H.2    Dray, A.3    Filosa, A.4    Perkins, M.N.5
  • 20
    • 4544235456 scopus 로고    scopus 로고
    • Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice
    • Nakahara K., Kojima M., Hanada R. et al. Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice. Biochem. Biophys. Res. Commun. (2004) 323 615 620.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 615-620
    • Nakahara, K.1    Kojima, M.2    Hanada, R.3
  • 21
    • 34250844458 scopus 로고    scopus 로고
    • Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses
    • Torres R., Croll S.D., Vercollone J. et al. Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain (2007) 130 267 278.
    • (2007) Pain , vol.130 , pp. 267-278
    • Torres, R.1    Croll, S.D.2    Vercollone, J.3
  • 22
    • 33845407004 scopus 로고    scopus 로고
    • Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding
    • Zeng H., Gragerov A., Hohmann J.G. et al. Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol. Cell. Biol. (2006) 26 9352 9363.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 9352-9363
    • Zeng, H.1    Gragerov, A.2    Hohmann, J.G.3
  • 23
    • 35748943212 scopus 로고    scopus 로고
    • Pharmacologic management of neuropathic pain: Evidence-based recommendations
    • Dworkin R.H., O'Connor A.B., Backonja M. et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain (2007) 132 237 251.
    • (2007) Pain , vol.132 , pp. 237-251
    • Dworkin, R.H.1    O'Connor, A.B.2    Backonja, M.3
  • 24
    • 33746311553 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of neuropathic pain
    • Truini A., Cruccu G. Pathophysiological mechanisms of neuropathic pain. Neurol. Sci. (2006) 27 S179 S182.
    • (2006) Neurol. Sci. , vol.27
    • Truini, A.1    Cruccu, G.2
  • 25
    • 33750048137 scopus 로고    scopus 로고
    • EFNS guidelineson pharmacological treatment of neuropathic pain
    • Attal N., Cruccu G., Haanpää M. et al. EFNS guidelineson pharmacological treatment of neuropathic pain. Eur. J. Neurol. (2006) 13 1153 1169.
    • (2006) Eur. J. Neurol. , vol.13 , pp. 1153-1169
    • Attal, N.1    Cruccu, G.2    Haanpää, M.3
  • 26
    • 0036772330 scopus 로고    scopus 로고
    • Evaluation of neuromedin U actions in energy homeostasis and pituitary function
    • Ivanov T.R., Lawrence C.B., Stanley P.J., Luckman S.M. Evaluation of neuromedin U actions in energy homeostasis and pituitary function. Endocrinology (2002) 143 3813 3821.
    • (2002) Endocrinology , vol.143 , pp. 3813-3821
    • Ivanov, T.R.1    Lawrence, C.B.2    Stanley, P.J.3    Luckman, S.M.4
  • 28
    • 34548514793 scopus 로고    scopus 로고
    • Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity
    • Novak C.M., Zhang M., Levine J.A. Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity. Brain Res. (2007) 1169 57 68.
    • (2007) Brain Res. , vol.1169 , pp. 57-68
    • Novak, C.M.1    Zhang, M.2    Levine, J.A.3
  • 29
    • 4444369414 scopus 로고    scopus 로고
    • Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight
    • Thompson E.L., Murphy K.G., Todd J.F. et al. Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight. Biochem. Biophys. Res. Commun. (2004) 323 65 71.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 65-71
    • Thompson, E.L.1    Murphy, K.G.2    Todd, J.F.3
  • 30
    • 85087537377 scopus 로고    scopus 로고
    • Brain oxytocin receptors mediate corticotropin releasing hormone induced anorexia
    • Olson B.R., Drutarosky M.D., Stricker E.M., Verbalis J.G. Brain oxytocin receptors mediate corticotropin releasing hormone induced anorexia. Am. J. Physiol. (2000) 91 R448 R452.
    • (2000) Am. J. Physiol. , vol.91
    • Olson, B.R.1    Drutarosky, M.D.2    Stricker, E.M.3    Verbalis, J.G.4
  • 31
    • 12344335083 scopus 로고    scopus 로고
    • Studies of the neuromedin U-2 receptor gene in human obesity: Evidence for the existence of two ancestral forms of the receptor
    • Bhattacharyya S., Luan J., Farooqi I.S. et al. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. J. Endocrinol. (2004) 183 115 120.
    • (2004) J. Endocrinol. , vol.183 , pp. 115-120
    • Bhattacharyya, S.1    Luan, J.2    Farooqi, I.S.3
  • 32
    • 33845509898 scopus 로고    scopus 로고
    • Association between neuromedin U gene variants and overweight and obesity
    • Hainerová I., Torekov S.S., Ek J. et al. Association between neuromedin U gene variants and overweight and obesity. J. Clin. Endocrinol. Metab. (2006) 91 5057 5063.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 5057-5063
    • Hainerová, I.1    Torekov, S.S.2    Ek, J.3
  • 33
    • 33745686120 scopus 로고    scopus 로고
    • Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis
    • Novak C.M., Zhang M., Levine J.A. Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis. J. Neuroendocrinol. (2006) 18 594 601.
    • (2006) J. Neuroendocrinol. , vol.18 , pp. 594-601
    • Novak, C.M.1    Zhang, M.2    Levine, J.A.3
  • 34
    • 34548514793 scopus 로고    scopus 로고
    • Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity
    • Novak C.M., Zhang M., Levine J.A. Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity. Brain Res. (2007) 1169 57 68.
    • (2007) Brain Res. , vol.1169 , pp. 57-68
    • Novak, C.M.1    Zhang, M.2    Levine, J.A.3
  • 36
    • 0345305837 scopus 로고    scopus 로고
    • Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: Effects of nutritional status
    • Graham E.S., Turnbull Y., Fotheringham P. et al. Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status. J. Neurochem. (2003) 87 1165 1173.
    • (2003) J. Neurochem. , vol.87 , pp. 1165-1173
    • Graham, E.S.1    Turnbull, Y.2    Fotheringham, P.3
  • 37
    • 10744233887 scopus 로고    scopus 로고
    • Central actionsof neuromedin U via corticotropin-releasing hormone
    • Hanada T., Date Y., Shimbara T. et al. Central actionsof neuromedin U via corticotropin-releasing hormone. Biochem. Biophys. Res. Commun. (2003) 311 954 958.
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 954-958
    • Hanada, T.1    Date, Y.2    Shimbara, T.3
  • 38
    • 33747881869 scopus 로고    scopus 로고
    • Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis
    • Nogueiras R., Tovar S., Mitchell S.E. et al. Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis. J. Endocrinol. (2006) 190 545 553.
    • (2006) J. Endocrinol. , vol.190 , pp. 545-553
    • Nogueiras, R.1    Tovar, S.2    Mitchell, S.E.3
  • 39
    • 23644445514 scopus 로고    scopus 로고
    • Neuromedin U - A new target in obesity
    • Doggrell S.A. Neuromedin U - a new target in obesity. Expert. Opin. Ther. Targets. (2005) 9 875 877.
    • (2005) Expert. Opin. Ther. Targets. , vol.9 , pp. 875-877
    • Doggrell, S.A.1
  • 40
    • 62849116156 scopus 로고    scopus 로고
    • Immunopharmacology
    • Katzung, B.G. (. Ed. The McGraw-Hill Companies Inc, USA, pp.
    • Lake D.F., Briggs A.D., Akporiaye E.T. Immunopharmacology, in : Katzung B.G. (Ed. Basic & Clinical Pharmacology, The McGraw-Hill Companies Inc, USA, 2004, pp. 931 957.
    • (2004) Basic & Clinical Pharmacology , pp. 931-957
    • Lake, D.F.1    Briggs, A.D.2    Akporiaye, E.T.3
  • 41
    • 10344225084 scopus 로고    scopus 로고
    • Neuromedin U elicits cytokine release in murine Th2 type T cell clone D10.G4.1
    • Johnson E.N., Appelbaum E.R., Carptenter D.C. et al. Neuromedin U elicits cytokine release in murine Th2 type T cell clone D10.G4.1. J. Immunol. (2004) 173 7230 7238.
    • (2004) J. Immunol. , vol.173 , pp. 7230-7238
    • Johnson, E.N.1    Appelbaum, E.R.2    Carptenter, D.C.3
  • 42
    • 22944465107 scopus 로고    scopus 로고
    • The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells
    • Moriyama M., Sato T., Inoue H. et al. The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J. Exp. Med. (2005) 202 217 223.
    • (2005) J. Exp. Med. , vol.202 , pp. 217-223
    • Moriyama, M.1    Sato, T.2    Inoue, H.3
  • 43
    • 32344438877 scopus 로고    scopus 로고
    • The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock
    • Moriyama M., Matsukawa A., Kudoh S. et al. The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock. Biochem. Biophys. Res. Commun. (2006) 341 1149 1154.
    • (2006) Biochem. Biophys. Res. Commun. , vol.341 , pp. 1149-1154
    • Moriyama, M.1    Matsukawa, A.2    Kudoh, S.3
  • 44
    • 41949091552 scopus 로고    scopus 로고
    • Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents
    • Iwai T., Iinuma Y., Kodani R., Oka J.I. Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents. Neurosci. Res. (2008) 61 113 119.
    • (2008) Neurosci. Res. , vol.61 , pp. 113-119
    • Iwai, T.1    Iinuma, Y.2    Kodani, R.3    Oka, J.I.4
  • 45
    • 0035959741 scopus 로고    scopus 로고
    • Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis
    • Alevizos I., Mahadevappa M., Zhang X. et al. Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene (2001) 20 6196 6204.
    • (2001) Oncogene , vol.20 , pp. 6196-6204
    • Alevizos, I.1    Mahadevappa, M.2    Zhang, X.3
  • 46
    • 4444353425 scopus 로고    scopus 로고
    • Neuromedin U: A Myb-regulated autocrine growth factor for human myeloid leukemias
    • Shetzline S.E., Rallapalli R., Dowd K.J., Zou S., Nakata Y., Swider C.R. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Blood (2004) 104 1833 1840.
    • (2004) Blood , vol.104 , pp. 1833-1840
    • Shetzline, S.E.1    Rallapalli, R.2    Dowd, K.J.3    Zou, S.4    Nakata, Y.5    Swider, C.R.6
  • 47
    • 33750323311 scopus 로고    scopus 로고
    • The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer
    • Takahashi K., Furukawa C., Takano A. et al. The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Res. (2006) 66 9408 9419.
    • (2006) Cancer Res. , vol.66 , pp. 9408-9419
    • Takahashi, K.1    Furukawa, C.2    Takano, A.3
  • 48
    • 33846846542 scopus 로고    scopus 로고
    • Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia
    • Wu Y., McRoberts K., Berr S.S., Frierson H.F. Jr., Conaway M., Theodorescu D. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene (2007) 26 765 773.
    • (2007) Oncogene , vol.26 , pp. 765-773
    • Wu, Y.1    McRoberts, K.2    Berr, S.S.3    Frierson Jr., H.F.4    Conaway, M.5    Theodorescu, D.6
  • 49
    • 15044363087 scopus 로고    scopus 로고
    • Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens
    • Euer N.I., Kaul S., Deissler H., Möbus V.J., Zeillinger R., Weidle U.H. Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens. Oncol. Rep. (2005) 13 375 387.
    • (2005) Oncol. Rep. , vol.13 , pp. 375-387
    • Euer, N.I.1    Kaul, S.2    Deissler, H.3    Möbus, V.J.4    Zeillinger, R.5    Weidle, U.H.6
  • 50
    • 34548412580 scopus 로고    scopus 로고
    • RhoGDI2: A new metastasis suppressor gene: Discovery and clinical translation
    • Harding M.A., Theodorescu D. RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation. Urol. Oncol. (2007) 25 401 406.
    • (2007) Urol. Oncol. , vol.25 , pp. 401-406
    • Harding, M.A.1    Theodorescu, D.2
  • 51
    • 11144356117 scopus 로고    scopus 로고
    • The gut brain peptide neuromedin U is involved in the mammalian circadian oscillator system
    • Nakahara K., Hanada R., Murakami N. et al. The gut brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem. Biophys. Res. Commun. (2004) 318 56 61.
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 56-61
    • Nakahara, K.1    Hanada, R.2    Murakami, N.3
  • 52
    • 0037089795 scopus 로고    scopus 로고
    • Cardiovascular actions of central neuromedin U in conscious rats
    • Chu C., Jin Q., Kunitake T. et al. Cardiovascular actions of central neuromedin U in conscious rats. Regul. Pept. (2002) 105 29 34.
    • (2002) Regul. Pept. , vol.105 , pp. 29-34
    • Chu, C.1    Jin, Q.2    Kunitake, T.3
  • 53
    • 85026139223 scopus 로고    scopus 로고
    • Hypotensive effects of neuromedin U microinjected into the cardiovascular-related region of the rat nucleus tractus solitarius
    • Tsubota Y., Kakimoto N., Owada-Makabe K. et al. Hypotensive effects of neuromedin U microinjected into the cardiovascular-related region of the rat nucleus tractus solitarius. Neuroreport (2003) 14 2387 2390.
    • (2003) Neuroreport , vol.14 , pp. 2387-2390
    • Tsubota, Y.1    Kakimoto, N.2    Owada-Makabe, K.3
  • 54
    • 0023667139 scopus 로고
    • Effect of synthetic neuromedin U-8 and U-25, novel peptides identified in porcine spinal cord, on splanchnic circulation in dogs
    • Sumi S., Inoue K., Kogire M. et al. Effect of synthetic neuromedin U-8 and U-25, novel peptides identified in porcine spinal cord, on splanchnic circulation in dogs. Life Sci. (1987) 41 1585 1590.
    • (1987) Life Sci. , vol.41 , pp. 1585-1590
    • Sumi, S.1    Inoue, K.2    Kogire, M.3
  • 57
    • 0036266843 scopus 로고    scopus 로고
    • Characterization of neuromedin U effects in canine smooth muscle
    • Westfall T.D., McCafferty G.P., Pullen M. et al. Characterization of neuromedin U effects in canine smooth muscle. J. Pharmacol. Exp. Ther. (2002) 301 987 992.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 987-992
    • Westfall, T.D.1    McCafferty, G.P.2    Pullen, M.3
  • 58
    • 33747364438 scopus 로고    scopus 로고
    • Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro
    • Jones N.A., Morton M.F., Prendergast C.E., Powell G.L., Shankley N.P., Hollingsworth S.J. Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro. Regul. Pept. (2006) 136 109 116.
    • (2006) Regul. Pept. , vol.136 , pp. 109-116
    • Jones, N.A.1    Morton, M.F.2    Prendergast, C.E.3    Powell, G.L.4    Shankley, N.P.5    Hollingsworth, S.J.6
  • 59
    • 33646593151 scopus 로고    scopus 로고
    • Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice
    • Prendergast C.E., Morton M.F., Figueroa K.W., Wu X., Shankley N.P. Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice. Br. J. Pharmacol. (2006) 147 886 896.
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 886-896
    • Prendergast, C.E.1    Morton, M.F.2    Figueroa, K.W.3    Wu, X.4    Shankley, N.P.5
  • 60
    • 0036805791 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    • Tsigos C., Chrousos G.P. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. Psychosom. Res. (2002) 53 865 871.
    • (2002) J. Psychosom. Res. , vol.53 , pp. 865-871
    • Tsigos, C.1    Chrousos, G.P.2
  • 61
    • 3543035811 scopus 로고    scopus 로고
    • Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U
    • Yokota M., Ozaki Y., Sakamoto F. et al. Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U. Stress (2004) 7 109 112.
    • (2004) Stress , vol.7 , pp. 109-112
    • Yokota, M.1    Ozaki, Y.2    Sakamoto, F.3
  • 63
    • 40249115226 scopus 로고    scopus 로고
    • Effects of neuromedin-U on immature rat adrenocortical cells: In vitro and in vivo studies
    • Ziolkowska A., Macchi C., Trejter M. et al. Effects of neuromedin-U on immature rat adrenocortical cells: in vitro and in vivo studies. Int. J. Mol. Med. (2008) 21 303 307.
    • (2008) Int. J. Mol. Med. , vol.21 , pp. 303-307
    • Ziolkowska, A.1    MacChi, C.2    Trejter, M.3
  • 64
    • 0242661557 scopus 로고    scopus 로고
    • Effects of neuromedin U on the pulsatile LH secretion in overiectomised rats in association with feeding conditions
    • Quan H., Funabashi T., Furuta M., Kimura F. Effects of neuromedin U on the pulsatile LH secretion in overiectomised rats in association with feeding conditions. Biochem. Biophys. Res. Commun. (2003) 311 721 727.
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 721-727
    • Quan, H.1    Funabashi, T.2    Furuta, M.3    Kimura, F.4
  • 65
    • 0036827818 scopus 로고    scopus 로고
    • Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat
    • Ozaki Y., Onaka T., Nakazato M. et al. Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology (2002) 143 4320 4329.
    • (2002) Endocrinology , vol.143 , pp. 4320-4329
    • Ozaki, Y.1    Onaka, T.2    Nakazato, M.3
  • 66
    • 33646911937 scopus 로고    scopus 로고
    • Regulation of gonadotropin secretion and puberty onset by neuromedin U
    • Fukue Y., Sato T., Teranishi H. et al. Regulation of gonadotropin secretion and puberty onset by neuromedin U. FEBS Lett. (2006) 580 3485 3488.
    • (2006) FEBS Lett. , vol.580 , pp. 3485-3488
    • Fukue, Y.1    Sato, T.2    Teranishi, H.3
  • 67
    • 41649106038 scopus 로고    scopus 로고
    • Estradiol suppresses NMU mRNA expression during sexual maturation in the female rat pituitary
    • Shimizu F., Matsuzaki T., Iwasa T. et al. Estradiol suppresses NMU mRNA expression during sexual maturation in the female rat pituitary. Int. J. Dev. Neurosci. (2008) 26 381 384.
    • (2008) Int. J. Dev. Neurosci. , vol.26 , pp. 381-384
    • Shimizu, F.1    Matsuzaki, T.2    Iwasa, T.3
  • 68
    • 5644294515 scopus 로고    scopus 로고
    • Intracerebroventricular injection of corticotropin-releasing hormone receptor antagonist blocks the suppression of pulsatile luteinizing hormone secretion induced by neuromedin U in ovariectomized rats after 48 hours of fasting
    • Quan H., Funabashi T., Kimura F. Intracerebroventricular injection of corticotropin-releasing hormone receptor antagonist blocks the suppression of pulsatile luteinizing hormone secretion induced by neuromedin U in ovariectomized rats after 48 hours of fasting. Neurosci. Lett. (2004) 369 33 38.
    • (2004) Neurosci. Lett. , vol.369 , pp. 33-38
    • Quan, H.1    Funabashi, T.2    Kimura, F.3
  • 69
    • 36148929381 scopus 로고    scopus 로고
    • Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod
    • Vigo E., Roa J., Pineda R. et al. Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod. Am. J. Physiol. Endocrinol. Metab. (2007) 293 E1265 E1273.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Vigo, E.1    Roa, J.2    Pineda, R.3
  • 70
    • 0346159170 scopus 로고    scopus 로고
    • Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors
    • Rokkaku K., Onaka T., Okada N. et al. Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors. Neuroreport (2003) 14 1997 2000.
    • (2003) Neuroreport , vol.14 , pp. 1997-2000
    • Rokkaku, K.1    Onaka, T.2    Okada, N.3
  • 71
    • 0023801587 scopus 로고
    • Neuromedin U octapeptide alters ion transport in porcine Jejunum
    • Brown D.R., Quito F.L. Neuromedin U octapeptide alters ion transport in porcine Jejunum. Eur. J. Pharmacol. (1988) 155 159 162.
    • (1988) Eur. J. Pharmacol. , vol.155 , pp. 159-162
    • Brown, D.R.1    Quito, F.L.2
  • 72
    • 33847107185 scopus 로고    scopus 로고
    • Neuromedin U can exert colon-specific, enteric nerve-mediated prokinetic activity, via a pathway involving NMU1 receptor activation
    • Dass N.B., Bassil A.K., North-Laidler V.J. et al. Neuromedin U can exert colon-specific, enteric nerve-mediated prokinetic activity, via a pathway involving NMU1 receptor activation. Br. J. Pharmacol. (2007) 150 502 508.
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 502-508
    • Dass, N.B.1    Bassil, A.K.2    North-Laidler, V.J.3
  • 73
    • 39049191471 scopus 로고    scopus 로고
    • Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets
    • Kaczmarek P., Malendowicz L.K., Pruszynska-Oszmalek E. et al. Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets. Int. J. Mol. Med. (2006) 18 951 955.
    • (2006) Int. J. Mol. Med. , vol.18 , pp. 951-955
    • Kaczmarek, P.1    Malendowicz, L.K.2    Pruszynska-Oszmalek, E.3
  • 74
    • 34948910681 scopus 로고    scopus 로고
    • Central control of bone remodeling by neuromedin U
    • Sato S., Hanada R., Kimura A. et al. Central control of bone remodeling by neuromedin U. Nat. Med. (2007) 13 1234 1240.
    • (2007) Nat. Med. , vol.13 , pp. 1234-1240
    • Sato, S.1    Hanada, R.2    Kimura, A.3


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