RhoGDI2: A new metastasis suppressor gene: Discovery and clinical translation

Urologic Oncology: Seminars and Original Investigations

Volumn 25, Issue 5, 2007, Pages 401-406

  Harding, Michael A ^a   Theodorescu, Dan ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Biomarker; Bladder cancer; GTPases; Metastasis

Indexed keywords

ENDOTHELIN 1; GENE PRODUCT; NEUROMODULIN; NEUROMODULIN U; PROTEIN RHOGDI2; UNCLASSIFIED DRUG;

BLADDER CANCER; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER MORTALITY; CANCER RISK; CANCER STAGING; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; METASTASIS SUPPRESSOR GENE; MICROARRAY ANALYSIS; MORBIDITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RHOGDI2 GENE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE, TUMOR; DOWN-REGULATION; ENDOTHELIN-1; FEMALE; GENES, TUMOR SUPPRESSOR; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEUROPEPTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RATS; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; URINARY BLADDER NEOPLASMS;

EID: 34548412580     PISSN: 10781439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urolonc.2007.05.006     Document Type: Review

References (20)

1. Sengelov L., Kamby C., and von der Maase H. Pattern of metastases in relation to characteristics of primary tumor and treatment in patients with disseminated urothelial carcinoma. J Urol 155 (1996) 111-114
2. Dinney C.P., McConkey D.J., Millikan R.E., et al. Focus on bladder cancer. Cancer Cell 6 (2004) 111-116
3. Gupta G.P., and Massague J. Cancer metastasis: Building a framework. Cell 127 (2006) 679-695
4. Rinker-Schaeffer C.W., O'Keefe J.P., Welch D.R., et al. Metastasis suppressor proteins: Discovery, molecular mechanisms, and clinical application. Clin Cancer Res 12 (2006) 3882-3889
5. Gildea J.J., Golden W.L., Harding M.A., et al. Genetic and phenotypic changes associated with the acquisition of tumorigenicity in human bladder cancer. Genes Chromosomes Cancer 27 (2000) 252-263
6. Seraj M.J., Harding M.A., Gildea J.J., et al. The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines. Clin Exp Metastasis 18 (2000) 519-525
7. Harding M.A., Arden K.C., Gildea J.W., et al. Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling. Cancer Res 62 (2002) 6981-6989
8. Gildea J.J., Seraj M.J., Oxford G., et al. RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 62 (2002) 6418-6423
9. Segal N.H., Pavlidis P., Noble W.S., et al. Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. J Clin Oncol 21 (2003) 1775-1781
10. Dhanasekaran S.M., Barrette T.R., Ghosh D., et al. Delineation of prognostic biomarkers in prostate cancer. Nature 412 (2001) 822-826
11. Beer D.G., Kardia S.L., Huang C.C., et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8 (2002) 816-824
12. Garber M.E., Troyanskaya O.G., Schluens K., et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA 98 (2001) 13784-13789
13. Theodorescu D., Sapinoso L.M., Conaway M.R., et al. Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 10 (2004) 3800-3806
14. DerMardirossian C., and Bokoch G.M. GDIs: Central regulatory molecules in Rho GTPase activation. Trends Cell Biol 15 (2005) 356-363
15. Golovanov A.P., Chuang T.H., DerMardirossian C., et al. Structure-activity relationships in flexible protein domains: Regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol 305 (2001) 121-135
16. Scheffzek K., Stephan I., Jensen O.N., et al. Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Mol Biol 7 (2000) 122-126
17. Oxford G., and Theodorescu D. The role of Ras superfamily proteins in bladder cancer progression. J Urol 170 (2003) 1987-1993
18. Titus B., Frierson Jr. H.F., Conaway M., et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 65 (2005) 7320-7327
19. Nelson J., Bagnato A., Battistini B., et al. The endothelin axis: emerging role in cancer. Nat Rev Cancer 3 (2003) 110-116
20. Brighton P.J., Szekeres P.G., and Willars G.B. Neuromedin U and its receptors: Structure, function, and physiological roles. Pharmacol Rev 56 (2004) 231-248