Association between neuromedin U gene variants and overweight and obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 12, 2006, Pages 5057-5063

  Hainerová, Irena ^a   Torekov, Signe S ^b   Ek, Jakob ^b,c   Finková, Marie ^a   Borch Johnsen, Knut ^b,e   Jørgensen, Torben ^d   Madsen, Ole D ^b   Lebl, Jan ^a   Hansen, Torben ^b   Pedersen, Oluf ^b,e  

^a CHARLES UNIVERSITY   (Czech Republic)

^b STENO DIABETES CENTER   (Denmark)

^c JOHN F KENNEDY INSTITUTE   (Denmark)

^d GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROMEDIN U;

ADULT; ALLELE; ARTICLE; BODY MASS; CHILD; COHORT ANALYSIS; CONFIDENCE INTERVAL; EXON; FEMALE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; HETEROZYGOTE DETECTION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL;

STENO;

EID: 33845509898     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1442     Document Type: Article

References (21)

1. Cummings DE, Schwartz MW 2003 Genetics and pathophysiology of human obesity. Annu Rev Med 54:453-471
2. Angelopoulos N, Goula A, Tolis G 2005 Current knowledge in the neurophysiologic modulation of obesity. Metabolism 54:1202-1217
3. Austin C, Lo G, Nandha KA, Meleagros L, Bloom SR 1995 Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. J Mol Endocrinol 14:157-169
4. Ballesta J, Carlei F, Bishop AE, Steel JH, Gibson SJ, Fahey M, Hennessey R, Domin J, Bloom SR, Polak JM 1988 Occurrence and developmental pattern of neuromedin U-immunoreactive nerves in the gastrointestinal tract and brain of the rat. Neuroscience 25:797-816
5. Domin J, Ghatei MA, Chohan P, Bloom SR 1987 Neuromedin U: a study of its distribution in the rat. Peptides 8:779-784
6. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M 2004 Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10:1067-1073
7. Kowalski TJ, Spar BD, Markowitz L, Maguire M, Golovko A, Yang S, Farley C, Cook JA, Tetzloff G, Hoos L, Del Vecchio RA, Kazdoba TM, McCool MF, Hwa JJ, Hyde LA, Davis H, Vassileva G, Hedrick JA, Gustafson EL 2005 Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice. J Endocrinol 185:151-164
8. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonals TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LHT, Liu Q 2000 Identification of receptors for neuromedin U and its role in feeding. Nature 406:70 -74
9. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, Matsukura S 2000 Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 277:191-194
10. Bhattacharyya S, Luan J, Farooqi IS, Keogh J, Montague C, Brennand J, Jorde L, Wareham NJ, O'Rahilly S 2004 Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. J Endocrinol 183:115-120
11. Deng HW, Deng H, Liu YJ, Liu YZ, Xu FH, Shen H, Conway T, Li JL, Huang QY, Davies KM, Recker RR 2002 A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet 70:1138-1151
12. Kobzová J, Vignerová J, Bláha P, Krejčovský L, Riedlová J 2004 The 6th nationwide anthropological survey of children and adolescents in the Czech Republic in 2001. Cent Eur J Public Health 2001 12:126-130
13. Jørgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glümer C, Pisinger C 2003 A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil 10:377-386
14. World Health Organization 1995 Report of a WHO Expert Committee. Physical status: the use and interpretation of anthropometry. World Health Organ Tech Rep Ser 854. Geneva: World Health Organization; 429-431
15. Stunkard A, Messick S 1985 The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29:71-83
16. Allison KC, Stunkard AJ, Their SL 2004 Overcoming night eating syndrome. A step-by-step to breaking the cycle. Oakland, CA: New Harbinger Publications
17. Devlin MJ, Goldfein JA, Dobrow I 2003 What is this thing called BED? Current status on binge eating nosology. Int J Eat Disord 34(Suppl 1):S2-S18
18. Pritchard JK, Stephens M, Donnelly PJ 2000 Inference of population structure using mulitlocus genotype data. Genetics 155:945-959
19. Ma L, Tataranni PA, Hanson RL, Infante AM, Kobes S, Bogardus C, Baier LJ 2005 Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Diabetes 54:1598-1602
20. Vicennati V, Geroni L, Genghini S, Patton L, Pagotto U, Pasquali R 2006 Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity. Obesity (Silver Spring) 14:235-243
21. Dubern B, Clément K, Pelloux V, Froguel P, Giradet JP, Guy-Grand B, Tounian P 2001 Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children. J Pediatr 139:204-209