Central actions of neuromedin U via corticotropin-releasing hormone

Biochemical and Biophysical Research Communications

Volumn 311, Issue 4, 2003, Pages 954-958

  Hanada, Takeshi ^a,b   Date, Yukari ^a   Shimbara, Takuya ^a   Sakihara, Satoru ^c   Murakami, Noboru ^d   Hayashi, Yujiro ^b   Kanai, Yasushi ^b   Suda, Toshihiro ^c   Kangawa, Kenji ^e   Nakazato, Masamitsu ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b SUNTORY LTD   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d UNIVERSITY OF MIYAZAKI   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

CRH; Energy homeostasis; Feeding behavior; Neuromedin U

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; NEUROMEDIN U; NEUROMEDIN U RECEPTOR; RECEPTOR PROTEIN; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BODY TEMPERATURE; CATABOLISM; CONTROLLED STUDY; DIET RESTRICTION; ENERGY METABOLISM; FEEDING BEHAVIOR; HORMONE ACTION; HORMONE SYNTHESIS; HYPOTHALAMUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL NETWORK; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; STRESS; WILD TYPE;

EID: 10744233887     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.10.098     Document Type: Article

References (31)

1. Minamino N., Kangawa K., Matsuo H. Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 130:1985;1078-1085.
2. O'Harte F., Bockman C.S., Abel P.W., Conlon J.M. Isolation, structural characterization and pharmacological activity of dog neuromedin U. Peptides. 12:1991;11-15.
3. Kage R., O'Harte F., Thim L., Conlon J.M. Rabbit neuromedin U-25: lack of conservation of a posttranslational processing site. Regul. Pept. 33:1991;191-198.
4. Domin J., Yiangou Y.G., Spokes R.A., Aitken A., Parmar K.B., Chrysanthou B.J., Bloom S.R. The distribution, purification, and pharmacological action of an amphibian neuromedin U. J. Biol. Chem. 264:1989;20881-20885.
5. Austin C., Lo G., Nandha K.A., Meleagros L., Bloom S.R. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. J. Mol. Endocrinol. 14:1995;157-169.
6. Conlon J.M., Domin J., Thim L., DiMarzo V., Morris H.R., Bloom S.R. Primary structure of neuromedin U from the rat. J. Neurochem. 51:1988;988-991.
7. Minamino N., Kangawa K., Honzawa M., Matsuo H. Isolation and structural determination of rat neuromedin U. Biochem. Biophys. Res. Commun. 156:1988;355-360.
8. Brown D.R., Quito F.L. Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur. J. Pharmacol. 155:1988;159-162.
9. Malendowicz L.K., Nussdorfer G.G., Markowska A., Tortorella C., Nowak M., Warchol J.B. Effects of neuromedin U (NMU)-8 on the rat hypothalamo-pituitary- adrenal axis. Evidence of a direct effect of NMU-8 on the adrenal gland. Neuropeptides. 26:1994;47-53.
10. Honzawa M., Sudoh T., Minamino N., Tohyama M., Matsuo H. Topographic localization of neuromedin U-like structures in the rat brain: an immunohistochemical study. Neuroscience. 23:1987;1103-1122.
11. Ballesta J., Carlei F., Bishop A.E., Steel J.H., Gibson S.J., Fahey M., Hennessey R., Domin J., Bloom S.R., Polak J.M. Occurrence and developmental pattern of neuromedin U-immunoreactive nerves in the gastrointestinal tract and brain of the rat. Neuroscience. 25:1988;797-816.
12. Howard A.D., Wang R., Pong S.S., Mellin T.N., Strack A., Guan X.M., Zeng Z., Williams D.L. Jr., Feighner S.D., Nunes C.N., Murphy B., Stair J.N., Yu H., Jiang Q., Clements M.K., Tan C.P., McKee K.K., Hreniuk D.L., McDonald T.P., Lynch K.R., Evans J.F., Austin C.P., Caskey C.T., Van der Ploeg L.H., Liu Q. Identification of receptors for neuromedin U and its role in feeding. Nature. 406:2000;70-74.
13. Fujii R., Hosoya M., Fukusumi S., Kawamata Y., Habata Y., Hinuma S., Onda H., Nishimura O., Fujino M. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J. Biol. Chem. 275:2000;21068-21074.
14. Szekeres P.G., Muir A.I., Spinage L.D., Miller J.E., Butler S.I., Smith A., Rennie G.I., Murdock P.R., Fitzgerald L.R., Wu H., McMillan L.J., Guerrera S., Vawter L., Elshourbagy N.A., Mooney J.L., Bergsma D.J., Wilson S., Chambers J.K. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J. Biol. Chem. 275:2000;20247-20250.
15. Kojima M., Haruno R., Nakazato M., Date Y., Murakami N., Hanada R., Matsuo H., Kangawa K. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem. Biophys. Res. Commun. 276:2000;435-438.
16. Nakazato M., Hanada R., Murakami N., Date Y., Mondal M.S., Kojima M., Yoshimatsu H., Kangawa K., Matsukura S. Central effects of neuromedin U in the regulation of energy homeostasis. Biochem. Biophys. Res. Commun. 277:2000;191-194.
17. Hanada R., Nakazato M., Murakami N., Sakihara S., Yoshimatsu H., Toshinai K., Hanada T., Suda T., Kangawa K., Matsukura S., Sakata T. A role for neuromedin U in stress response. Biochem. Biophys. Res. Commun. 289:2001;225-228.
18. Mondal M.S., Date Y., Murakami N., Toshinai K., Shimbara T., Kangawa K., Nakazato M. Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via corticotropin-releasing hormone system. Am. J. Physiol. Gastrointest. Liver Physiol. 284:2003;G963-G969.
19. Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 213:1981;1394-1397.
20. Sutton R.E., Koob G.F., Le Moal M., Rivier J., Vale W. Corticotropin releasing factor produces behavioural activation in rats. Nature. 297:1982;331-333.
21. Muglia L., Jacobson L., Dikkes P., Majzoub J.A. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 373:1995;427-432.
22. Kanatani A., Mashiko S., Murai N., Sugimoto N., Ito J., Fukuroda T., Fukami T., Morin N., MacNeil D.J., Van der Ploeg L.H., Saga Y., Nishimura S., Ihara M. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 141:2000;1011-1016.
23. Niimi M., Murao K., Taminato T. Central administration of neuromedin U activates neurons in ventrobasal hypothalamus and brainstem. Endocrine. 16:2001;201-206.
24. Ozaki Y., Onaka T., Nakazato M., Saito J., Kanemoto K., Matsumoto T., Ueta Y. Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology. 143:2002;4320-4329.
25. Malendowicz L.K., Nussdorfer G.G., Nowak K.W., Mazzocchi G. Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis. In Vivo. 7:1993;419-422.
26. Wren A.M., Small C.J., Abbott C.R., Jethwa P.H., Kennedy A.R., Murphy K.G., Stanley S.A., Zollner A.N., Ghatei M.A., Bloom S.R. Hypothalamic actions of neuromedin U. Endocrinology. 143:2002;4227-4234.
27. LeFeuvre R.A., Rothwell N.J., Stock M.J. Activation of brown fat thermogenesis in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology. 26:1987;1217-1221.
28. Arase K., York D.A., Shimizu H., Shargill N., Bray G.A. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am. J. Physiol. 255:1988;E255-E259.
29. Rothwell N.J. Central effects of CRF on metabolism and energy balance. Neurosci. Biobehav. Rev. 14:1990;263-271.
30. Heinrichs S.C., Richard D. The role of corticotropin-releasing factor and urocortin in the modulation of ingestive behavior. Neuropeptides. 33:1999;350-359.
31. Ivanov T.R., Lawrence C.B., Stanley P.J., Luckman S.M. Evaluation of neuromedin U actions in energy homeostasis and pituitary function. Endocrinology. 143:2002;3813-3821.