Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis

Toxicology and Applied Pharmacology

Volumn 236, Issue 2, 2009, Pages 231-238

  Wu, Yi Chen ^a   Yen, Wen Yen ^a,b   Lee, Te Chang ^a,c   Yih, Ling Huei ^a  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Apoptosis; Arsenic trioxide; Heat shock proteins; Mitotic arrest

Indexed keywords

17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; ARSENIC TRIOXIDE; BUB1 RELATED PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; KNK 437; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; METAPHASE; MITOSIS INHIBITION; MITOSIS SPINDLE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; ARSENICALS; BENZHYDRYL COMPOUNDS; BENZOQUINONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; LACTAMS, MACROCYCLIC; MITOSIS; OXIDES; PYRROLIDINONES;

EID: 62549157049     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.003     Document Type: Article

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