-
1
-
-
0034924812
-
Folding of newly translated proteins in vivo: the role of molecular chaperones
-
Frydman J. Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu. Rev. Biochem. 70 (2001) 603-647
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 603-647
-
-
Frydman, J.1
-
3
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery
-
Pratt W.B., and Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. (Maywood) 228 (2003) 111-133
-
(2003)
Exp. Biol. Med. (Maywood)
, vol.228
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
4
-
-
33646371494
-
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
-
Arlander S.J., et al. Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J. Biol. Chem. 281 (2006) 2989-2998
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2989-2998
-
-
Arlander, S.J.1
-
5
-
-
1642505452
-
Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase
-
Lee P., et al. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol. Biol. Cell 15 (2004) 1785-1792
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 1785-1792
-
-
Lee, P.1
-
6
-
-
33747878717
-
Structure of an Hsp90-Cdc37-Cdk4 complex
-
Vaughan C.K., et al. Structure of an Hsp90-Cdc37-Cdk4 complex. Mol. Cell 23 (2006) 697-707
-
(2006)
Mol. Cell
, vol.23
, pp. 697-707
-
-
Vaughan, C.K.1
-
7
-
-
33746364784
-
Structure and mechanism of the Hsp90 molecular chaperone machine
-
Pearl L.H., and Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machine. Ann. Rev. Biochem. 75 (2006) 271-294
-
(2006)
Ann. Rev. Biochem.
, vol.75
, pp. 271-294
-
-
Pearl, L.H.1
Prodromou, C.2
-
8
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., et al. The protein kinase complement of the human genome. Science 298 (2002) 1912-1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
-
9
-
-
4444353636
-
Regulation of protein kinases; controlling activity through activation segment conformation
-
Nolen B., et al. Regulation of protein kinases; controlling activity through activation segment conformation. Mol. Cell 15 (2004) 661-675
-
(2004)
Mol. Cell
, vol.15
, pp. 661-675
-
-
Nolen, B.1
-
10
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M., and Kuriyan J. The conformational plasticity of protein kinases. Cell 109 (2002) 275-282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
11
-
-
0037436388
-
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure
-
Akamine P., et al. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J. Mol. Biol. 327 (2003) 159-171
-
(2003)
J. Mol. Biol.
, vol.327
, pp. 159-171
-
-
Akamine, P.1
-
12
-
-
0031578579
-
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions
-
Williams J.C., et al. The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. J. Mol. Biol. 274 (1997) 757-775
-
(1997)
J. Mol. Biol.
, vol.274
, pp. 757-775
-
-
Williams, J.C.1
-
13
-
-
1842477464
-
Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4
-
Zhao Q., et al. Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4. J. Biol. Chem. 279 (2004) 12560-12564
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12560-12564
-
-
Zhao, Q.1
-
14
-
-
4544254444
-
Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37
-
Prince T., and Matts R.L. Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. J. Biol. Chem. 279 (2004) 39975-39981
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 39975-39981
-
-
Prince, T.1
Matts, R.L.2
-
15
-
-
27744562164
-
Cdk2: a genuine protein kinase client of Hsp90 and Cdc37
-
Prince T., et al. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry 44 (2005) 15287-15295
-
(2005)
Biochemistry
, vol.44
, pp. 15287-15295
-
-
Prince, T.1
-
16
-
-
33646269303
-
Cdc37 interacts with the glycine-rich loop of hsp90 client kinases
-
Terasawa K., et al. Cdc37 interacts with the glycine-rich loop of hsp90 client kinases. Mol. Cell. Biol. 26 (2006) 3378-3389
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3378-3389
-
-
Terasawa, K.1
-
17
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
-
Basso A.D., et al. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J. Biol. Chem. 277 (2002) 39858-39866
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39858-39866
-
-
Basso, A.D.1
-
18
-
-
33244484848
-
Targeting chaperones in transformed systems-a focus on Hsp90 and cancer
-
Chiosis G. Targeting chaperones in transformed systems-a focus on Hsp90 and cancer. Expert Opin. Ther. Targets 10 (2006) 37-50
-
(2006)
Expert Opin. Ther. Targets
, vol.10
, pp. 37-50
-
-
Chiosis, G.1
-
19
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A., et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425 (2003) 407-410
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
-
20
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A., et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425 (2003) 407-410
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
-
21
-
-
33646725129
-
A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues
-
Gooljarsingh L.T., et al. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 7625-7630
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 7625-7630
-
-
Gooljarsingh, L.T.1
-
22
-
-
0035793546
-
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
-
Xu W., et al. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J. Biol. Chem. 276 (2001) 3702-3708
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3702-3708
-
-
Xu, W.1
-
23
-
-
15544372341
-
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
-
Xu W., et al. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nat. Struct. Mol. Biol. 12 (2005) 120-126
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 120-126
-
-
Xu, W.1
-
24
-
-
0037224231
-
Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation
-
Tikhomirov O., and Carpenter G. Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. Cancer Res. 63 (2003) 39-43
-
(2003)
Cancer Res.
, vol.63
, pp. 39-43
-
-
Tikhomirov, O.1
Carpenter, G.2
-
25
-
-
33744931946
-
Hsp90 recognizes a common surface on client kinases
-
Citri A., et al. Hsp90 recognizes a common surface on client kinases. J. Biol. Chem. 281 (2006) 14361-14369
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14361-14369
-
-
Citri, A.1
-
26
-
-
0037474219
-
A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases
-
Bandhakavi S., et al. A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases. J. Biol. Chem. 278 (2003) 2829-2836
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2829-2836
-
-
Bandhakavi, S.1
-
27
-
-
0141755381
-
Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37
-
Shao J., et al. Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. J. Biol. Chem. 278 (2003) 38117-38120
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38117-38120
-
-
Shao, J.1
-
28
-
-
1942486312
-
CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37
-
Miyata Y., and Nishida E. CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol. Cell. Biol. 24 (2004) 4065-4074
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 4065-4074
-
-
Miyata, Y.1
Nishida, E.2
-
29
-
-
0032897474
-
Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases
-
Sakagami M., et al. Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases. Cell Stress Chaperones 4 (1999) 19-28
-
(1999)
Cell Stress Chaperones
, vol.4
, pp. 19-28
-
-
Sakagami, M.1
-
30
-
-
28244444919
-
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
-
da Rocha Dias S., et al. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res. 65 (2005) 10686-10691
-
(2005)
Cancer Res.
, vol.65
, pp. 10686-10691
-
-
da Rocha Dias, S.1
-
31
-
-
30444441778
-
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
-
Grbovic O.M., et al. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 57-62
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 57-62
-
-
Grbovic, O.M.1
-
32
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116 (2004) 855-867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
-
33
-
-
2942744500
-
Regulation of the Src family kinase Lck by Hsp90 and ubiquitination
-
Giannini A., and Bijlmakers M.J. Regulation of the Src family kinase Lck by Hsp90 and ubiquitination. Mol. Cell. Biol. 24 (2004) 5667-5676
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5667-5676
-
-
Giannini, A.1
Bijlmakers, M.J.2
-
34
-
-
27744551993
-
Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37
-
Prince T., and Matts R.L. Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. Biochem. Biophys. Res. Commun. 338 (2005) 1447-1454
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.338
, pp. 1447-1454
-
-
Prince, T.1
Matts, R.L.2
-
35
-
-
18744373865
-
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
-
Yang J., et al. Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat. Struct. Biol. 9 (2002) 940-944
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 940-944
-
-
Yang, J.1
-
36
-
-
0029665779
-
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
-
Stepanova L., et al. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10 (1996) 1491-1502
-
(1996)
Genes Dev.
, vol.10
, pp. 1491-1502
-
-
Stepanova, L.1
-
37
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
-
Jeffrey P.D., et al. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376 (1995) 313-320
-
(1995)
Nature
, vol.376
, pp. 313-320
-
-
Jeffrey, P.D.1
-
38
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
Yang J., et al. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol. Cell 9 (2002) 1227-1240
-
(2002)
Mol. Cell
, vol.9
, pp. 1227-1240
-
-
Yang, J.1
-
39
-
-
1542269006
-
PKA: a portrait of protein kinase dynamics
-
Taylor S.S., et al. PKA: a portrait of protein kinase dynamics. Biochim. Biophys. Acta 1697 (2004) 259-269
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, pp. 259-269
-
-
Taylor, S.S.1
-
40
-
-
27144551963
-
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia
-
Castro J.E., et al. ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. Blood 106 (2005) 2506-2512
-
(2005)
Blood
, vol.106
, pp. 2506-2512
-
-
Castro, J.E.1
-
41
-
-
20444413061
-
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways
-
McClellan A.J., et al. Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways. Cell 121 (2005) 739-748
-
(2005)
Cell
, vol.121
, pp. 739-748
-
-
McClellan, A.J.1
-
42
-
-
0035816574
-
Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70
-
Gusarova V., et al. Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70. J. Biol. Chem. 276 (2001) 24891-24900
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24891-24900
-
-
Gusarova, V.1
-
43
-
-
0034661466
-
CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90
-
Goasduff T., and Cederbaum A.I. CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90. Arch. Biochem. Biophys. 379 (2000) 321-330
-
(2000)
Arch. Biochem. Biophys.
, vol.379
, pp. 321-330
-
-
Goasduff, T.1
Cederbaum, A.I.2
-
44
-
-
0036789884
-
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
-
Xu W., et al. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12847-12852
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 12847-12852
-
-
Xu, W.1
-
45
-
-
0034720255
-
Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia
-
Stepanova L., et al. Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene 19 (2000) 2186-2193
-
(2000)
Oncogene
, vol.19
, pp. 2186-2193
-
-
Stepanova, L.1
-
46
-
-
0033863883
-
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome
-
An W.G., et al. The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome. Cell Growth Differ. 11 (2000) 355-360
-
(2000)
Cell Growth Differ.
, vol.11
, pp. 355-360
-
-
An, W.G.1
-
47
-
-
0028828273
-
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent
-
Smith D.F., et al. Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent. Mol. Cell. Biol. 15 (1995) 6804-6812
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 6804-6812
-
-
Smith, D.F.1
|