Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells

Cancer Research

Volumn 59, Issue 4, 1999, Pages 776-780

  Li, Yong Ming ^a   Broome, John D ^b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ARSENIC; COLCHICINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PACLITAXEL; TUBULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; BONE MARROW CELL; CANCER CELL; CELL DEATH; CONTROLLED STUDY; CROSS LINKING; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; METAPHASE; MICROTUBULE; MITOSIS INHIBITION; MYELOID LEUKEMIA; PRIORITY JOURNAL;

APOPTOSIS; ARSENIC; BINDING SITES; GUANOSINE TRIPHOSPHATE; HUMANS; K562 CELLS; LEUKEMIA, MYELOID; MITOSIS; TUBULIN;

EID: 0000928694     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Forkner, C. E. Leukemia, and Allied Disorders. New York: The MacMillian Company, 1938.
2. Sun, H. D., Ma. L., Hu, X. C. and Zhang, T. D. Treatment of acute promyelocytic leukemia by Aliling-1 therapy with use of syndrome differentiation of traditional Chinese medicine. Chin. J. Comb. Trad. Chin. Med. West Med., 12: 170-171, 1992.
3. 3 induces NB4 cell apoptosis with down-regulation of Bcl-2 expression and modulation of PML-RARα/PML proteins. Blood, 88: 1052-1061, 1996.
4. 3) in the treatment of acute promyelocytic leukemia (APL). II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood, 89: 3354-3360, 1997.
5. Soignet, S. L., Maslak, P., Wang, Z. G., Jhanwar, S., Calleja, E., Dardashti, L. J., Corso, D., DeBlasio, A., Gabrilove, J., Scheinberg, D. A., Pandolfi, P. P., and Warrell, R. P. Jr. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N. Engl. J. Med., 339: 1341-1348, 1998.
6. Jiang Su New Medical College. Encyclopedia of Chinese Medicine, pp. 1620-1622. Shanghai, China: Shanghai Scientific Publishing House, 1986.
7. Zhu, Z., Koken, M. H., Quignon, F., Chelbi-Alix, M. K., Degos, L., Wang, Z. Y., Chen, Z., and de The, H. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA, 94: 3978-3983, 1997.
8. Wang, Z. G., Rivi, R., Delva, L., Konig, A., Scheinberg, D. A., Gambacorti-Passerini, C., Gabrilove, J. L., Warrell, R. P. Jr., and Pandolfi, P. P. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML/RAR-α independent manner. Blood, 92: 1497-1504.
9. Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th ed., p. 697. New York: McGraw-Hill, 1994.
10. Li, W., and Chou, I. N. Effects of sodium arsenite on the cytoskeleton and cellular glutathione levels in cultured cells. Toxicol. Appl. Pnarmacol., 114: 132-139, 1992.
11. Hoffman, R. D., and Lane, M. D. Iodophenylarsine oxide and arsenical affinity chromatography: new probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway. J. Biol. Chem., 267: 14005-14011, 1992.
12. Debec, A., Courgeon, A. M., Maingourd, M., and Maisonhaute, C. The response of the centrosome to heat shock and related stresses in a Drosophila cell line. J. Cell Sci., 96: 403-412, 1990.
13. Ramirez, P., Eastmond, D. A., Laclette, J. P., and Ostrosky-Wegman, P. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat. Res., 386: 291-298, 1997.
14. Li, Y. M., and Broome, J. D. Apoptosis induced in premyelocytic leukemia cells by arsenic and proteasome inhibitors. Blood, 90 (Suppl. 1): 202b, 1997.
15. Nakajima, O., Sugishita, Y., Hashimoto, Y., and Iwasaki, S. Increase in the chemically induced differentiation of human leukemia cell lines by tubulin disrupters. Biol. Pharm. Bull., 17: 742-744, 1994.
16. Srivastava, R. K., Kormeyer, S. J., Nesterova, M., Cho-Chung, Y. S., and Longo, D. L. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell. Biol., 18: 3509-3517, 1998.
17. Sherwood, S. W., Sheridan, J. P., and Schimke, R. T. Induction of apoptosis by the anti-tubulin drug Colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells. Exp. Cell Res., 215: 373-379, 1994.
18. Nogales, E., Wolf, S. G., and Downing, K. H. Structure of the α β tubulin dimer by electrocrystallography. Nature (Lond.), 391: 199-202, 1998.
19. Little, M., and Luduena, R. F. Location of two cysteines in brain β1-tubulin that can be cross-linked after removal of exchangeable GTP. Biochim. Biophys. Acta, 912: 28-33, 1987.
20. Stiakaki, E., Stournaras, C., Dimitriou, H., and Kalmanti, M. High sensitivity of leukemic peripheral blood lymphocytes to triethyllead action. Biochem. Pharmacol. 54: 1371-1376, 1997.