Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice

Pharmacogenetics and Genomics

Volumn 19, Issue 3, 2009, Pages 217-225

  Correa, Mercè ^a   Viaggi, Cristina ^c   Escrig, Miguel A ^a   Pascual, Maria ^b   Guerri, Consuelo ^b   Vaglini, Francesca ^c   Aragon, Carlos M G ^a   Corsini, Giovanni U ^c  

^a UNIVERSITAT JAUME I   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

Acetaldehyde; Alcohol; Catalase; Cytochrome; Drug sensitization; Ethanol metabolism; Locomotion; Voluntary intake

Indexed keywords

ACETALDEHYDE; ALCOHOL; CATALASE; CYTOCHROME P450 2E1;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; LOCOMOTION; MALE; MICE; MICE, KNOCKOUT;

ANIMALIA; MUS;

EID: 62349093610     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328324e726     Document Type: Article

References (52)

1. Lieber CS. The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug Metab Rev 2004; 36: 511-529.
2. Lucas D, Menez JF, Berthou F, Cauvin JM, Deitrich RA. Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats. Alcohol Clin Exp Res 1992; 16:916-921.
3. Roberts BJ, Shoaf SE, Song BJ. Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats. Biochem Pharmacol 1995; 26:1665-1673.
4. Zerilli A, Lucas D, Amet Y, Beauge F, Volant A, Folch HH, et al. Cytochrome P-450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation. Alcohol Alcohol 1995; 30:357-365.
5. Carpenter SP, Lasker JM, Raucy JL Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes. Mol Pharmacol 1996; 49:260-268.
6. Kunitoh S, Tanaka T, Imaoka S, Funae Y, Monna Y. Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol Alcohol Suppl 1993; 1B:63-68.
7. Hansson T, Tindberg N, Ingelman-Sundberg M, Köhler C. Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system. Neuroscience 1990; 34:451-463.
8. Anandatheerthavarada HK, Shankar SK, Bhamre S, Boyd MR, Song BJ, Ravindranath V. Induction of brain cytochrome P-450IIE1 by chronic ethanol treatment. Brain Res 1993; 601:279-285.
9. Warner M, Gustafsson JA. Effect of ethanol on cytochrome P450 in the rat brain. Proc Natl Acad Sci U S A 1994; 91:1019-1023.
10. Montoliu C, Vallés S, Renau-Piqueras J, Guerri C. Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption. J Neurochem 1994; 63:1855-1862.
11. Sánchez-Catalán MJ, Hipolito L, Guerri C, Granero L, Polache A. Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat. Alcohol Alcohol 2008; 43: 401-407.
12. Farin FM, Omiecinski CJ. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. J Toxicol Environ Health 1993; 40:317-335.
13. Boutelet-Bochan H, Huang Y, Juchau MR. Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndrome. Biochem Biophys Res Commun 1997; 238:443-447.
14. Miksys S, Tyndale RF. The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. Drug Metab Rev 2004; 36:313-333.
15. Montoliu C, Sancho-Tello M, Azorin I, Burgal M, Vallés S, Renau-Piqueras J, Guerri C. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. J Neurochem 1995; 65:2561-2570.
16. Tindberg N, Ingelman-Sundberg M. Expression, catalytic activity, and inducibility of cytochrome P450 2E1 (CYP2E1) in the rat central nervous system. J Neurochem 1996; 67:2066-2073.
17. Vaglini F, Pardini C, Viaggi C, Bartoli C, Dinucci D, Corsini GU. Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. J Neurochem 2004; 91:285-298.
18. Aragon CM, Rogan F, Amit Z. Ethanol metabolism in rat brain homogenates by acatalase-H2O2 system. Biochem Pharmacol 1992; 44:93-98.
19. Gill K, Menez JF, Lucas D, Deitrich RA. Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol Clin Exp Res 1992; 16:910-915.
20. Zimatkin SM, Deitrich RA. Ethanol metabolism In the brain. Addict Biol 1997; 2:387-400.
21. Zimatkin SM, Pronto SP, Vasiliou V, Gonzalez FJ, Deitrich RA. Enzymatic mechanisms of ethanol oxidation in the brain. Alcohol Clin Exp Res 2006; 30:1500-1505.
22. Martinez SE, Vaglenova J, Sabrià J, Martinez MC, Farrés J, Parés X. Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and rctinoid metabolism. Eur J Biochem 2001; 268:5045-5056.
23. Zimatkin SM. Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem 1991; 56:1-11.
24. Amit Z, Aragon CM. Catalase activity measured in rats naive to ethanol correlates with later voluntary ethanol consumption: possible evidence for a biological marker system of ethanol intake. Psychopharmacology 1988; 95:512-515.
25. Smith BR, Aragon CMG, Amit Z. Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol. Addict Biol 1997; 2:277-289.
26. Correa M, Sanchis-Segura C, Pastor R, Aragon CM. Ethanol intake and motor sensitization: the role of brain catalase activity in mice with different genotypes. Physiol Behav 2004; 82:231-240.
27. Quertemont E. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol Psychiatry 2004; 9:570-581.
28. Deng X, Deitrich RA. Putative role of brain acetaldehyde in ethanol addiction. Curr Drug Abuse Rev 2008; 1:3-8.
29. Vasiliou V, Ziegler TL, Bludeau P, Petersen DR, Gonzalez FJ, Deitrich RA. CYP2E1 and catalase influence ethanol sensitivity in the central nervous system. Pharmacogenet Genom 2006; 16:51-58.
30. Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 1996; 271:12063-12067.
31. Kelley AE. Locomotor activity and exploration. In: Sahgal A, editor. Behavioral neuroscience. A practical approach. Oxford: Oxford University Press; 1993. pp. 1-21.
32. Quertemont E, Green HL, Grant KA. Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time. Psychopharmacology 2003; 168:262-270.
33. Viaggi C, Vaglini F, Pardini C, Sgado P, Caramelli A, Corsini GU. CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity. J Neural Transm Suppl 2007; 72:159-163.
34. Kim YD, Oyama T, Isse T, Kim H, Kawamoto T. Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study. Arch Toxicol 2005; 79:192-195.
35. Oyama T, Isse T, Kagawa N, Kinaga T, Kim YD, Morita M, et al. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. Front Biosci 2005; 10:951-960.
36. Corsini GU, Zuddas A, Bonuccelli U, Schinelli S, Kopin IJ. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by ethanol or acetaldehyde. Life Sci 1987; 40:827-832.
37. Terelius Y, Norsten-Höög C, Cronholm T, Ingelman-Sundberg M. Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1). Biochem Biophys Res Commun 1991; 179:689-694.
38. Aragon CMG, Pesold CN, Amit Z. Ethanol-induced motor activity in normal and acatalasemic mice. Alcohol 1992; 9:207-211.
39. Aragon CMG, Amit Z. Differences in ethanol-induced behaviors in normal and acatalasemic mice: systematic examination using a behavioral approach. Pharmacol Biochem Behav 1993; 44:547-554.
40. Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P4502E1 gene. J Biochem 1991; 110:559-565.
41. Watanabe J, Hayashi S, Kawajiri K. Different regulation and expression of the human CYP2E1 gene due to the Rsa1 polymorphism in the 5′-flanking region. J Biochem 1994; 116:321-326.
42. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M. Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. Alcohol din Exp Res 1997; 21:596-601.
43. Okamoto K, Murawaki Y, Yuasa I, Kawasaki H. Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers. Alcohol Clin Exp Res 2001; 25: 19S-23S.
44. Plee-Gautier E, Foresto F, Ferrara R, Bodénez P, Simon B, Manno M, et al. Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics. Alcohol Clin Exp Res 2001; 25:800-804.
45. Itoga S, Harada S, Nomura F. Polymorphism of the 5′-flanking region of the CYP2E1 gene: an Association study with alcoholism. Alcohol Clin Exp Res 2001; 25:11S-15S.
46. Vidal F, Lorenzo A, Auguet T, Olona M, Broch M, Gutiérrez C, et al. Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-l and Pst-1, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. J Hepatol 2004; 41:744-750.
47. Mulligan CJ, Robin RW, Osier MV, Sambuughin N, Goldfarb LG, Kittles RA, et al. Allelic variation at alcohol metabolism genes (ADHIB, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet 2003; 113:325-336.
48. Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet 2006; 78:973-987.
49. Peng GS, Chen YC, Tsao TP, Wang MF, Yin SJ. Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genom 2007; 17:845-855.
50. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, et al. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity, Pharmacogenetics 2002; 12:621-626.
51. Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 2005; 29:1959-1964.
52. He XX, Nebert DW, Vasiliou V, Zhu H, Shertzer HG. Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics 1997; 7:223-233.