1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by ethanol or acetaldehyde

Life Sciences

Volumn 40, Issue 9, 1987, Pages 827-832

  Corsini, G U ^a   Zuddas, A ^b   Bonuccelli, U ^b   Schinelli, S ^b   Kopin, I J ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETALDEHYDE; ALCOHOL;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; DRUG POTENTIATION; INTOXICATION; MOUSE; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ACETALDEHYDE; ANIMALS; BRAIN; DOPAMINE; DRUG SYNERGISM; ETHANOL; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; MALE; MICE; MICE, INBRED C57BL; NEUROTOXINS; PYRIDINES; SEROTONIN;

ANIMALIA;

EID: 0023152213     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(87)90030-0     Document Type: Article

References (24)

1. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.