Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1771, Issue 9, 2007, Pages 1186-1194

  Li, Zhiqiang ^a   Hailemariam, Tiruneh K ^a   Zhou, Hongwen ^a   Li, Yan ^a   Duckworth, Dale C ^b   Peake, David A ^b   Zhang, Youyan ^b   Kuo, Ming Shang ^b   Cao, Guoqing ^b   Jiang, Xian Cheng ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Lipid drafts; SMS1 and SMS2 siRNA; Sphingomyelin; Sphingomyelin synthase 1 and 2

Indexed keywords

CARBON 14; CERAMIDE; DETERGENT; DIACYLGLYCEROL; LIPID; LYSENIN; PHOSPHATIDYLCHOLINE; PROTEIN; SERINE; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE 1; SPHINGOMYELIN SYNTHASE 2; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL MEMBRANE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOLYSIS; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIPID ANALYSIS; LIPID METABOLISM; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

ANIMALS; BRIDGED COMPOUNDS; CELL LINE; CELL MEMBRANE; CERAMIDES; HUMANS; ISOENZYMES; MEMBRANE LIPIDS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PHOSPHODIESTERASE INHIBITORS; RNA, SMALL INTERFERING; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; THIONES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 34548604943     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2007.05.007     Document Type: Article

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