Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: A new prognostic factor

Clinical Cancer Research

Volumn 5, Issue 3, 1999, Pages 593-599

  Vogel, Ilka ^a   Krüger, Uwe ^a   Marxsen, Jan ^a   Soeth, Edlyn ^a   Kalthoff, Holger ^a   Henne Bruns, Doris ^a   Kremer, Bernd ^a   Juhl, Hartmut ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE MARROW METASTASIS; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISSEMINATED CANCER; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MINIMAL RESIDUAL DISEASE; PANCREAS CANCER; PERITONEUM LAVAGE; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL TIME;

BONE MARROW; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM METASTASIS; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PERITONEAL CAVITY; PROGNOSIS; SURVIVAL RATE;

EID: 0344359791     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Warshaw, A. L., and Fernandez-del Castillo, C. Pancreatic Cancer. N. Engl. J. Med., 326: 455-465, 1992.
2. Henne-Bruns, D., Vogel, I., Lüttges, J., Klöppel, G., and Kremer, B. Ductal adenocarcinoma of the pancreas head: survival after regional versux extended lymphadenectomy. Hepato-Gastroenterology, 45: 855-866, 1998.
3. Hamilton J. Adjuvant therapy for gastrointestinal cancer. Curr. Opin. Oncol., 6: 435-440, 1994.
4. Schmiegel, W., Schmielau, J., Henne-Bruns, D., Juhl, H., Roeder, C., Buggisch, P., Onur, A., Kremer, B., Kalthoff, H., and Jensen, E. Cytokine-mediated epidermal growth factor receptor manipulation: basis and therapeutic application in pancreatic cancer. Proc. Natl. Acad. Sci. USA, 94: 12622-12626, 1997.
5. Simeone, D., Cascarelli, A., and Logsdon, C. Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumor cell proliferation. Surgery (St. Louis), I22: 428-434, 1997.
6. Molino, A., Colombatti, M., Bonetti, F., Zardini, M., Pasini, F., Perini, A., Pelosi, G., Tridente, G., Veneri, D., and Cetto, G. L. A comparative analysis of three different techniques for the detection of breast cancer cells in bone marrow. Cancer (Phila.). 67: 1033-1034, 1991.
7. Diel, I., Kaufmann, M., Costa, S. D., Holle, R., Minckwitz, G., Solomayer, E. F., Kaul, S., and Bastert, G. Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J. Natl. Cancer Inst. (Bethesda), 88: 1652-1658, 1996.
8. Pantel, K., Izbicki, J., Passlick, B., Angstwurm, M., Haussinger, K., Thetter, D., and Riethmüller, G. Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet, 347: 649-653, 1996.
9. Combaret, V., Favrot, M. C., Kremens, B., Philip, J., Bailly, C., Fontaniere, B., Gentilhomme, O., Chauvin, F., Zucker, J. M., Bernard, J. L., and Philip, T. Immunological detection of neuroblastoma cells in bone marrow harvested for autologous transplantation. Br. J. Cancer, 59: 844-847, 1989.
10. Riesenberg, R., Oberneder, R., Kriegmair, M., Epp, M., Bitzer, U., Hofstetter, A., Braun, S., Riethmüller, G., and Pantel, K. Immunocytological double staining of cytokeratin and prostate specific antigen in individual prostatic tumor cells. Histochemistry, 99: 61-66, 1993.
11. Schlimok, G., Funke, I., Pantel, K., Strobel, F., Lindemann, F., Witte, J., and Riethmüller, G. Micrometastatic tumor cells in bone marrow of patients with gastric cancer: methodological aspects of detection and prognostic significance. Eur. J. Cancer, 27: 1461-1465, 1991.
12. Schlimok, G., Funke, I., Holzmann, B., Gottlinger, G., Schmidt, G., Hauser, H., Swierkot, S., Warnecke, H., Schneider, B., Koprowski, H., and Riethmüller, G. Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1-A monoclonal antibodies. Proc. Natl. Acad. Sci. USA, 84: 8672-8676, 1987.
13. Juhl, H., Stritzel, M., Wroblewski, A., Henne-Bruns, D., Kremer, B., Schmiegel, W. H., Neumaier, M., Wagener, C., Schreiber, H. W., and Kalthoff, H. Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and in the bone marrow of gastric, colorectal and pancreatic cancer patients. Int. J. Cancer, 57: 330-335, 1994.
14. Juhl, H., Kalthoff, H., Krüger, U., Schott, A., Schreiber, H. W., Henne-Bruns, D., and Kremer, B. Immunzytologischer nachweis disseminierter tumorzellen in der bauchhöhle und im knochenmark von pankreaskarzinompatienten. Chirurg., 65: 1111-1115, 1994.
15. Klöppel, G. Pancreatic, non-endocrine tumors. In: G. Klöppel and P. U. Heitz (eds.), Pancreatic Pathology, pp. 79-113. New York: Churchill Livingstone, 1984.
16. Schott, A., Vogel, I., Krüger, U., Kalthoff, H., Schreiber, H-W., Schmiegel, W., Henne-Bruns, D., Kremer, B., and Juhl, H. Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker. Ann. Surg., 227: 372-379, 1998.
17. Hammarstrom, S., Shively, J. E., Paxton, R. J., Beatty, B. G., Larsson, Å., Ghosh, R., Bormer, O., Buchegger, F., Mach, J-P., Burtin, P., Seguin. P., Darbouret, B., Degorce, F., Sertour, J., Jolu, J.P., Fuks, A., Kalthoff, H., Schemiegel, W., Arndt, R., Klöppel, G., von Kleist, S., Grunert, F., Schwarz, K., Matsuoka, Y., Kuroki, M., Wagener, C., Weber, T., Yachi, A., Imai, K., Hishikawa, N., and Tsujisaki, M. Antigenetic sites in carcinoembryonic antigen. Cancer Res., 49: 4852-4858, 1989.
18. Koprowski, H., Steplewski, Z., Mitchell, K., Herlyn, M., Herlyn, D., and Führer, P. Colorectal carcinoma antigens detected by hybridoma antibodies. Somat. Cell Genet., 5: 957-972, 1979.
19. Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H. Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc. Natl. Acad. Sci. USA, 76: 1438-1442, 1979.
20. Kalthoff, H., Holl, K., Schmiegel, W., Klöppel, G., Arndt, R., and Matzku, S. A new mucin reacting monoclonal antibody for serum diagnosis and radioimmunoscintigraphy of pancreatic cancer. J. Tumor-marker Oncol., 2: 75, 1987.
21. Schmiegel, W., Kalthoff, H., Arndt, R., Gieseking, J., Greten, H., Klöppel, G., Kreiker, C., Ladak, A., Lamprepe, V., and Ulrich, S. Monoclonal antibody-defined human pancreatic cancer-associated antigens. Cancer Res., 45: 1402-1407, 1985.
22. Hermanek, P., Scheibe, O., Spiessl, B., and Wagner, G. UICC TNM-Klassifikation Maligner Tumoren, Ed. 4. Berlin: Springer-Verlag, 1997.
23. Redding, W. H., Coombes, R. C., Monoghan, P., Clink, H. M., Imrie, S. F., Dearnaley, D. P., Ormerod, D. P., Sloane, J. P., Gazet, J. C., and Powles, T. J. Detection of micrometastases in patients with primary breast cancer. Lancet., 2: 1271-1274, 1983.
24. Warshaw, A. L. Implications of peritoneal cytology for staining of early pancreatic cancer. Am. J. Surg., 161: 26-30, 1991.
25. Lüttges, J., Neumann, K., Pflüger, K-H., and Schmitz-Moormann, P. Differentialzytologie von ergussflüssigkeiten unter anwendung von monoklonalen antikörpern. Pathologe. 9: 137-142, 1988.
26. Lemoine, A., Le Bricon, T., Salvucci, M., Azoulay, D., Pham, P., Raccucia, J., Bismuth, H., and Debuire, B. Prospective evaluation of circulating hepatocytes by α-fetoprotein mRNA in humans during liver surgery. Ann. Surg., 226: 43-50, 1997.
27. Soeth, E., Vogel, I., Roeder, C., Juhl, H., Marxsen, J., Krüger, U., Henne-Bruns, D., Kremer, B., and Kalthoff, H. Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR. Cancer Res., 57: 3106-3110, 1997.
28. Nakajima, T., Harashima, S., Hirata, M., and Kajitani, T. Prognostic and therapeutic values of peritoneal cytology in gastric cancer. Acta Cytol., 22: 225-229, 1978.
29. Lindemann, F., Schlimok, G., Dirschedel, P., Witte, J., and Riethmüller, G. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet. 340: 685-689, 1992.
30. Jauch, K. W., Heiss, M. M., Gruetzner, U., Funke, I., Pantel, K., Babic, R., Eissner, H-J., Riethmüller, G., and Schildberg, F-W. Prognostic significance of bone marrow micrometastases in patients with gastric cancer. J. Clin. Oncol., 14: 1810-1817, 1996.
31. Thorban, S., Roder, J., Nekarda, H., Funk, A., Siewert, R., and Pantel, K. Immunocytochemical detection of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma. J. Natl. Cancer Inst. (Bethesda), 88: 1222-1227, 1996.
32. Thorban, S., Roder, J., Pantel, K., and Siewert, R. Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma. Am. J. Surg., 172: 297-298, 1996.
33. Pantel, K., Schlimok, G., Braun, S., Kutter, D., Lindemann, F., Schaller, G., Funke, I., Izbicki, J., and Riethmüller, G. Differential expression of proliferation-associated molecules in individual micrometastalic carcinoma cells. J. Natl. Cancer Inst. (Bethesda), 85: 1419-1424, 1993.
34. Makary, M. A., Warshaw, A. L., Ceneno, B. A., Willet, C. G., Rattner, D. W., and Fernandez-del Castillo, C. Influence of peritoneal cytology on treatment of patients with pancreatic cancer. Arch. Surg., 133: 361-365, 1998.