Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients

American Journal of Pathology

Volumn 151, Issue 4, 1997, Pages 943-949

  Hruban, Ralph H ^a,d   Sturm, Patrick D J ^b   Slebos, Robbert J C ^b   Wilentz, Robb E ^a   Musler, Alex R ^b   Yeo, Charles J ^a   Sohn, Taylor A ^a   Van Velthuysen, Marie Louise F ^c   Offerhaus, G Johan A ^b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d Meyer 7 181 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN;

ADULT; AGED; ARTICLE; BILE DUCT DISEASE; CLINICAL ARTICLE; CODON; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER GRANULOMA; LIVER METASTASIS; MALE; MOLECULAR DYNAMICS; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL;

ADENOCARCINOMA; BILE DUCT NEOPLASMS; BILE DUCTS; CELL DIVISION; CODON; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EPITHELIUM; HUMANS; LIVER NEOPLASMS; PANCREATIC NEOPLASMS; POINT MUTATION; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 0030846221     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, Dooley WC, Coleman J, Pitt HA: Pancreaticoduodenectomy for cancer of the head of the pancreas: 201 patients. Ann Surg 1995, 221:721-733
2. Mixter CG, Mixter CG Jr: Liver nodules encountered at laparotomy: significance and treatment. Ann Surg 1953, 138:230-239
3. Zittel RX, Wegner G: The differential diagnosis of benign cholangioma and liver metastases. German Med Month 1969, 14:531-532
4. Allaire GS, Rabin L, Ishak KG, Sesterhenn IA: Bile duct adenoma: a study of 152 cases. Am J Surg Pathol 1988, 12:708-715
5. Govindarajan S, Peters RL: The bile duct adenoma: a lesion distinct from Meyenburg complex. Arch Pathol Lab Med 1984, 108:922-924
6. Chung EB: Multiple bile-duct hamartomas. Cancer 1970, 26:287-296
7. Dekker A, Ten Kate FJW, Terpstra OT: Cholangiocarcinoma associated with multiple bile duct hamartomas of the liver. Digestive Dis Sci 1989, 34:952-958
8. Melnick PJ: Polycystic liver: analysis of seventy cases. Arch Pathol 1955, 59:162-172
9. Thommesen N: Biliary hamartomas (von Meyenburg complexes) in liver needle biopsies. Arch Pathol Microbiol Scand 1978, 86:93-99
10. Cho C, Rullis I, Rogers LS: Bile duct adenomas as liver nodules. I. Adenomas. Arch Surg 1978, 113:272-274
11. Henson SW Jr, Gary HK, Dockerty MB: Benign tumors of the liver. Surg Gynecol Obstet 1956, 103:23-30
12. Hruban RH, van der Riet P, Erozan YS, Sidransky D: Molecular biology and the early detection of carcinoma of the bladder: the case of Hubert H. Humphrey. N Engl J Med 1994, 330:1276-1278
13. van Es JM, Polak MM, van den Berg FM, Ramsoekh TB, Craanen ME, Hruban RH, Offerhaus GJA: Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product. J Clin Pathol 1995, 48:218
14. Caldas C, Hahn SA, Hruban RH, Redston MS, Yeo CJ, Kern SE: Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 1994, 54:3568-3573
15. Tada M, Omata M, Kawai S, Saisho H, Ohio M, Saiki RK, Sninsky JJ: Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res 1993, 53:2472-2474
16. Apple SK, Hecht JR, Novak JM, Nieberg RK, Rosenthal DL, Grody WW: Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears. Am J Clin Pathol 1996, 105:321-326
17. Hruban RH, van Mansfeld ADM, Offerhaus GJA, van Weering DHJ, Allison DC, Goodman SN, Kensler TW, Bose KK, Cameron JL, Bos JL: K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993, 143:545-554
18. Watanabe M, Asaka M, Tanaka J, Kurosawa M, Kasai M, Miyazaki T: Point mutation of K-ras gene codon 12 in biliary tract tumors. Gastroenterology 1994, 107:1147-1153
19. Tada M, Yokosuka O, Omata M, Ohio M, Isono K: Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing Cancer 1990, 66:930-935
20. Scarpa A, Zamboni G, Achille A, Capelli P, Bogina G, Iacono C, Serio G, Accolla RS: ras-family gene mutations in neoplasia of the ampulla of Vater. Int J Cancer 1994, 59:39-42
21. Wright DK, Manos MM: Sample preparation from paraffin-embedded tissues. PCR Protocols. Edited by Innes MA, Gelfand DH, Sninsky JJ, White TJ. San Diego, Academic Press, 1990, pp 153-158
22. Slebos RJC, Boerrigter L, Evers SG, Wisman P, Mooi WJ, Rodenhuis S: A rapid and simple procedure for the detection of ras mutations in formalin-fixed paraffin-embedded tissue. Diagn Mol Pathol 1992, 1: 136-141
23. Westra WH, Baas IO, Hruban RH, Askin FB, Wilson K, Offerhaus GJA, Slebos RJC: K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res 1996, 56:2224-2228
24. Chung CH, Wilentz RE, Polak MM, Ramsoekh TB, Noorduyn LA, Gouma DJ, Huibregtse K, Offerhaus GJA, Slebos RJC: Clinical significance of K-ras oncogene activation in ampullary neoplasms. J Clin Pathol 1996, 49:460-464
25. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977, 74:5463-5467
26. Ishak KG, Rabin L: Benign tumors of the liver. Med Clin North Am 1975, 59:995-1013
27. DiGiuseppe JA, Hruban RH, Offerhaus GJA, Clement MJ, van den Berg FM, Cameron JL, van Mansfeld ADM: Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma. Am J Pathol 1994, 144:889-895
28. Iguchi H, Sugano K, Fukayama N, Ohkura H, Sadamoto K, Ohkoshi K, Seo Y, Tomoda H, Funakoshi A, Wakasugi H: Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer. Gastroenterology 1996, 110:221-226
29. Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, Yoshida H, Machinami R, Kishi K, Omata M: Analysis of K-ras mutation in hyperplastic duct cells of the pancreas without pancreas disease. Gastroenterology 1996, 110:227-231
30. Slebos RJC, Sturm PDJ, Noorduyn LA, Polak MM, Musler A, Caspers E, Ramsoekh TB, Huibregtse K, Hruban RH, Offerhaus GJA: K-ras oncogens mutations in cytologic brush specimens from tumors in the head region of the human pancreas. 1997 (in press)
31. Foucar E: Bile duct adenoma. Arch Pathol Lab Med 1985, 109:590
32. Foucar E, Kaplan LR, Gold JH, Kiang DT, Sibley RK, Bosl G: Well differentiated peripheral cholangiocarcinoma with an unusual clinical course. Gastroenterology 1979, 77:347-353
33. Hasebe T, Sakamoto M, Mukai K, Kawano N, Konishi M, Ryu M, Fukamachi S, Hirohashi S: Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. Virchows Arch 1995, 426:209-213