γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

Brain Research

Volumn 1262, Issue , 2009, Pages 89-99

  Minogue, Aedín M ^a   Stubbs, Adam K ^a   Frigerio, Carlo Sala ^a   Boland, Barry ^a   Fadeeva, Julia V ^b   Tang, Jordan ^c   Selkoe, Dennis J ^b   Walsh, Dominic M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Aggregation; Alzheimer's disease; Amyloid protein; Amyloid precursor like protein 1; Fibrillogenesis; Neurotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR LIKE PROTEIN 1; AMYLOID PRECURSOR LIKE PROTEIN 1 DERIVED PEPTIDE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; MOLECULAR SIZE; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; SEQUENCE HOMOLOGY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA, CONDITIONED; HIPPOCAMPUS; HUMANS; MOLECULAR SEQUENCE DATA; NEURONS; NEUROTOXINS; PEPTIDE FRAGMENTS; RABBITS; RATS; RATS, WISTAR; TRANSFECTION;

CRICETULUS GRISEUS;

EID: 62249105153     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.01.008     Document Type: Article

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