The protective role of selenium on genetic damage and on cancer

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 475, Issue 1-2, 2001, Pages 123-139

  El Bayoumy, Karam ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

Apoptosis; Cancer; Cell proliferation; Chromosomal damage; Micronuclei; Oxidative damage; Selenium

Indexed keywords

CARCINOGEN; EBSELEN; MUTAGENIC AGENT; SELENITE; SELENIUM; SELENOCYSTEINE; SELENOMETHIONINE;

CANCER; CARCINOGENESIS; CELL GROWTH; CELL PROTECTION; CHROMOSOME DAMAGE; DNA ADDUCT; DNA DAMAGE; DOSE RESPONSE; GENETIC DAMAGE; GENETIC STABILITY; HUMAN; MINERAL DEFICIENCY; MINERAL INTAKE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CLINICAL TRIALS; DNA ADDUCTS; DNA DAMAGE; HUMANS; NEOPLASMS; NUTRITION POLICY; SELENIUM;

ANIMALIA;

EID: 0035906330     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00075-6     Document Type: Review

References (167)

1. Contribution of the environment to cancer incidence: An epidemiologic exercise
2. Nature and nurture: Possibilities for cancer control
3. The lessons of life: Keynote address to the nutrition and cancer conference
4. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
5. Dietary control of cancer
6. Diet, nutrition and avoidable cancer
7. The nutritional biochemistry of selenium
8. Foods
9. Selenium bioavailability with reference to human nutrition
10. Selenium
11. Pathways of selenium metabolism including respiratory excretory products
12. The importance of selenium to human health
13. On the nature of selenium toxicity and carcinostatic activity
14. Selenium inhibition of chemical carcinogenesis
15. The role of selenium in cancer prevention
16. Chemopreventive agents: Selenium
17. Lessons from basic research in selenium and cancer prevention
18. Selenium as an integral part of factor 3 against necrotic liver degeneration
19. Selenium: Biochemical role as a component of glutathione peroxidase
20. Possible protective effect of selenium against human cancer
21. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer
22. Prospective study of serum micronutrients and ovarian cancer
23. Thyroid hormones and selenium status in breast cancer
24. Plasma selenium levels and the risk of colorectal adenomas
25. Effect of radiotherapy and chemoradiotherapy on circulating antioxidant system of human uterine cervical carcinoma
26. Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China
27. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China
28. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong
29. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
30. Nutrition intervention trials in Linxian, China: Multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia
31. Micronuclei and carcinogen DNA adducts as intermediate end points in nutrient intervention trial of precancerous lesions in the oral cavity
32. Chemoprevention of metachronous adenomas of the large bowel by means of antioxidants: A double-blind randomized trial
33. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: A randomized controlled trial
34. Decreased incidence of prostate cancer with selenium supplementation: Results of a double-blind cancer prevention trial
35. Influence of selenium, age, and dosage of 7,12-dimethylbenz(a)anthracene (DMBA) on the in vivo formation of DNA adducts in mammary tissue
36. In vitro and in vivo effects of sodium selenite on 7,12-dimethylbenz(a)anthracene-DNA adduct formation in isolated rat mammary epithelial cells
37. Inhibition of 7,12-dimethylbenz(a)anthracenebenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite
38. Effects of selenium on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis and DNA adduct formation
39. Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats
40. Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate
41. Effect of dietary soy protein isolate, genistein, and 1,4-phenylenebis(methylene)selenocyanate on DNA binding of 7,12-dimethylbenz(a)anthracene in mammary glands of CD rats
42. Structure-activity relationships among the ortho-, meta- and para-isomers of phenylenebis(methylene)selenocyanate (XSC) as inhibitors of 7,12-dimethylbenz(a)anthracene-DNA binding in mammary glands of female CD rats
43. Chemoprevention of mammary cancer by diallyl selenide, a novel organoselenium compound
44. 1 in rats
45. Effects of dietary selenium and vitamin E on covalent binding of aflatoxin to chick liver cell macromolecules
46. Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats
47. The chemical form of selenium influences 3,2′-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon
48. Enhancement of the repair of carcinogen-induced DNA damage in the hamster pancreas by dietary selenium
49. Age, dietary selenium and quantity of 7,12-dimethylbenz(a)anthracene influence the in vivo occurrence of rat mammary DNA adducts
50. Effect of dietary selenium on the interaction between 2-acetylaminofluorene and rat liver DNA in vivo
51. Selective effects of selenium on 7,12-dimethylbenz(a)anthracene-DNA binding in fetal mouse cell cultures
52. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression
53. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: A review and tribute to Charles Brenton Huggins
54. Polycyclic aromatic hydrocarbon carcinogens
55. Hepatic metabolism of 7,12-dimethylbenz(a)anthracene in male, female, and ovariectomized Sprague-Dawley rats
56. Comparison of 7,12-dimethylbenz(a)anthracene metabolism and DNA binding in mammary epithelial cells from three rat strains with differing susceptibilities to mammary carcinogenesis
57. 32P-postlabeled rat mammary DMBA-DNA adducts
58. DNA adduct formation by 7,12-dimethylbenz(a)anthracene and its noncarcinogenic 2-fluoro analogue in female Sprague-Dawley rats
59. Effect of dietary butylated hydroxytoluene on the in vivo distribution, metabolism, and DNA-binding of 7,12-dimethylbenz(a)anthracene
60. Comparative effects of phenylebis(methylene)selenocyanate isomers on xenobiotic metabolizing enzymes in organs of female CD rats
61. Cancer chemoprevention by aliphatic selenocyanates: Effect of chain length on inhibition of mammary tumors and DMBA adducts
62. Nutrition and tobacco-related cancer
63. Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats
64. Protection by vitamin E, selenium, and β-carotene against oxidative damage in rat liver slices and homogenate
65. Antioxidant activity of ebselen and related selenoorganic compounds in microsomal lipid peroxidation
66. Inhibition of 7,12-dimethylbenz(a)anthracene-induced lipid peroxidation and mammary tumor development in rats by vitamin E in conjunction with selenium
67. 1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA
68. Enhancement of the repair of carcinogen-induced DNA damage in the hamster pancreas by dietary selenium
69. Elevated 8-hydroxy-2′-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate
70. Pulmonary lipid peroxidation and antioxidant defenses during exhaustive physical exercise: The role of vitamin E and selenium
71. 10, β-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo
72. Protection by vitamin E, selenium, trolox, ascorbic acid palmitate, acetylcysteine, coenzyme Q, β-carotene, and (+)-catechin against oxidative damage to rat liver and heart tissue slices measured by oxidized heme proteins
73. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: Complexities with thioredoxin reductase
74. Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA
75. Endogenous oxidative DNA damage, aging, and cancer
76. Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbol acetate
77. In vivo oxidative DNA damage: Measurement of 8-hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection
78. Hydroxyl free radical adduct of deoxyguanosine: Sensitive detection and mechanism of formation
79. Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels
80. 1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA
81. Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
82. Oxidative DNA damage in tissues of pregnant female mice and fetuses caused by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
83. Exposure of mammalian cell cultures to benzo(a)pyrene and light results in oxidative DNA damage as measured by 8-hydroxydeoxyguanosine formation
84. 7,12-Dimethylbenz(a)anthracene induces oxidative DNA modification in vivo
85. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats with the hepatocarcinogen 2-nitropropane
86. Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage
87. 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage
88. Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on γ-irradiation in aqueous solution
89. 32P-postlabeling
90. Immunoaffility isolation of urinary 8-hydroxyguanine-2′-deoxyguanosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2′-deoxyguanosine in DNA by polyclonal antibodies
91. Quantitative immunoanalysis of promutagenic 8-hydroxy-2′-deoxyguanosine in oxidized DNA
92. Commentary: The measurement of oxidative damage to DNA by HPLC and GC/MS techniques
93. 1-treated rat liver and human oral mucosal cells
94. Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes
95. Oxidative DNA-damage estimated by 8-hydroxydeoxyguanosine excretion in humans: Influence of smoking, gender and body mass index
96. Smoking and vitamin C
97. The relation of diet, cigarette smoking, and alcohol consumption to plasma β-carotene and α-tocopherol levels
98. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene
99. Effects of antioxidant supplementation on platelet function: A randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status
100. DNA base modifications in chromatin of human cancerous tissues
101. Determination of 8-hydroxyguanosine by immunoaffinity chromatography-monoclonal antibody-based ELISA
102. Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate
103. 10 and selenium protect tissues against lipid peroxidation in rat tissue slices
104. The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz(a)anthracene on 8-hydroxy-2′-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene)selenocyanate
105. Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite
106. Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells
107. Inhibitory effects of selenium on the growth of L1210 leukemic cells
108. Factors influencing the antitumorigenic properties of selenium in mice
109. Effect of selenium on growth rate of canine mammary carcinoma cells in athymic nude mice
110. The selenium metabolite selenodiglutathione induces p53 and apoptosis: Relevance to the chemopreventive effects of selenium?
111. 2 toxicity
112. Comparison of the effects of an organic and inorganic form of selenium on a mammary carcinoma cell line
113. Effects of organic and inorganic selenium compounds on rat mammary tumor cells
114. Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell cultured model
115. Selenium inhibition of DNA synthesis in mouse mammary epithelial cell line YN-4
116. Selenite: A good inhibitor of rat liver DNA methylase
117. The antileukaemic effects and the mechanism of sodium selenite
118. Dietary selenium intake and growth of the MT-W9B transplantable rat mammary tumor
119. Differential effects of selenium on normal and neoplastic canine mammary cells
120. Uptake and localization of selenium-75 in mammary epithelial cells in vitro
121. Apoptosis induced by selenium in human glioma cell lines
122. Effect of selenium on malignant tumor cells in brain
123. Modulation of oxidative damage to DNA be sodium selenite via the mechanism of apoptosis
124. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant responds faster
125. Distinct effects of glutathione disuphide on the nuclear transcription factor κB and the activator protein-1
126. Mechanisms of chemoprevention and growth inhibition by selenium compounds
127. Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways
128. Spontaneous nucleosomal DNA fragmentation in murine leukemic L1210 cells
129. Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells
130. Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells
131. Dissociation of the genotoxic and growth inhibitory effects of selenium
132. Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention
133. Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage
134. Evaluation of benzyl selenocyanate glutathione conjugate for potential chemopreventive properties in colon carcinogenesis
135. Inhibition of PKC and PKA by chemopreventive organoselenium compounds
136. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: Its role in inhibition of tumor promotion
137. Inhibition of thymidine kinase in cultured mammary tumor cells by the chemopreventive organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate
138. 2+-dependent protein kinase (protein kinase C) system from human leukemic cells
139. Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?
140. Effects of chemopreventive selenium compounds on Jun-N-kinase activities
141. Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells
142. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation
143. Selenium modulation of cell proliferation and cell cycle biomarkers in normal and pre-malignant cells of the rat mammary gland
144. Mechanisms in the chemoprevention of colon cancer: Modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis(methylene)selenocyanate and impact of low-fat diet
145. Seleno amino compounds from Astragalus bisculcatus: Isolation and identification of γ-L-glutamyl-Se-methylseleno-L-cysteine and Se-methyl-seleno-L-cysteine
146. Allium chemistry: Identification of selenoamino acids in ordinary and selenium-enriched garlic, onion, and broccoli using gas chromatography with atomic emission detection
147. High-performance liquid chromatography of selenoamino acids and organoselenium compounds: Speciation by inductively coupled plasma mass spectrometry
148. Analytical selenoamino acid studies by chromatography with interfaced atomic mass spectrometry and atomic emission spectral detection
149. Speciation of selenoamino acids and organoselenium compounds in selenium-enriched yeast using high-performance liquid chromatography-inductively coupled plasma mass spectrometry
150. Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations
151. Studies of safe maximal daily dietary intake in a seleniferous area in China. Part II. Relation between selenium intake and manifestations of clinical signs and certain biological altercations
152. Selenium in diet, blood, and toenails in relation to human health in a seleniferous area
153. Prevention of cytotoxic effects of arsenic by short-term dietary supplementation with selenium in mice in vivo
154. Chromosome aberrations, sister-chromatid exchanges and cell-cycle kinetics in human peripheral blood lymphocytes exposed to organoselenium in vitro
155. Antagonistic effect of calcium, zinc and selenium against cadmium-induced chromosomal aberrations and micronuclei in root cells of Hordeum vulgare
156. Effects of Se-enriched malt cakes on UV/benzo(a)pyrene-induced unscheduled DNA synthesis of lymphocytes from high risk population of lung cancer
157. Investigation of protective effect of selenium on genetic materials among workers exposed to arsenic
158. 3 on the damages of genetic materials induced by MNNG in children's foreskin fibroblasts in vitro
159. Metabolism of selenium in humans