2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

Molecules

Volumn 14, Issue 2, 2009, Pages 785-797

  Zhu, Jin ^a   Chen, Tong ^a   Liu, Jie ^a   Ruoqun, Ma ^a   Lu, Weiqiang ^a   Huang, Jin ^a   Li, Honglin ^a   Li, Jian ^a   Jiang, Hualiang ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

2 (3,4 Dihydro 4 oxothieno 2,3 d pyrimidin 2 ylthio)acetamide derivatives; Falcipain 2 inhibitor; Malaria; SAR

Indexed keywords

ACETAMIDE DERIVATIVE; ANTIMALARIAL AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; MALARIA FALCIPARUM; METABOLISM; MICROBIOLOGICAL EXAMINATION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETAMIDES; ANIMALS; ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; MALARIA, FALCIPARUM; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61449142511     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14020785     Document Type: Article

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