A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT1A receptors, but a higher density of 5-HT1B receptors, compared to control rats

Neurochemistry International

Volumn 54, Issue 5-6, 2009, Pages 299-307

  Nishi, Kyoko ^a   Kanemaru, Kazuya ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Animal models; Autoradiography; Brain receptors; Depression; Depression model; FRL rats; Serotonin receptors; Sprague Dawley rats

Indexed keywords

CITALOPRAM; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; SEPTUM NUCLEUS; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENETIC PREDISPOSITION TO DISEASE; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; SYNAPTIC TRANSMISSION; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 61449100319     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.12.011     Document Type: Article

References (68)

1. Alpers H.S., and Himwich H.E. The effects of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine. J. Pharmacol. Exp. Ther. 180 (1972) 531-538
2. Amaral D.G., and Witter M.P. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31 (1989) 571-591 (Review)
3. Amsterdam J.D. Gepirone, a selective serotonin (5HT1A) partial agonist in the treatment of major depression. Prog. Neuropshychopharmacol. Biol. Psychiatry 16 (1992) 271-280
4. Assié M.B., Cosi C., and Koek W. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. Eur. J. Pharmacol. 386 1 (1999) 97-103
5. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
6. Blier P., and de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 15 7 (1994) 220-226 (Review)
7. Caccia S., Anelli M., Codegoni A.M., Fracasso C., and Garattini S. The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain. Br. J. Pharmacol. 110 (1993) 355-359
8. Celada P., Puig M., Amargós-Bosch M., Adell A., and Artigas F. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J. Psychiatry Neurosci. 29 4 (2004) 252-265
9. De Vry J. 5-HT1A receptor agonists: recent developments and controversial issues. Psychopharmacology (Berl) 121 1 (1995) 1-26 (Review)
10. Dewar K.M., Grondin L., Nénonéné E.K., Ohayon M., and Reader T.A. [3H] paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. Eur. J. Pharmacol. 235 (1993) 137-142
11. Dilsaver S.C. Cholinergic mechanisms in affective disorders. Future directions for investigation. Acta Psychiatry Scand. 74 4 (1986) 312-334
12. Dobson C.F., Tohyama Y., Diksic M., and Hamel E. Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia 24 1 (2004) 2-11
13. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Holt D., Greer P.J., Huang Y., Gautier C., and Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry 46 (1999) 1375-1387
14. Engel G., Göthert M., Hoyer D., Schlicker E., and Hillenbrand K. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch. Pharmacol. 332 1 (1986) 1-7
15. Hamon M., Bourgoih S., Morot-Gaudry Y., and Glowinski J. End product inhibition of serotonin synthesis in the rat striatum. Nat. New Biol. 237 (1972) 184-187
16. Hasegawa S., Watanabe A., Nishi K., Nguyen K.Q., and Diksic M. Selective 5-HT(1B) receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study. Neurochem. Int. 46 (2005) 261-272
17. Hasegawa S., Watanabe A., Nguyen K.Q., Debonnel G., and Diksic M. Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study. Psychopharmacology 179 (2005) 781-790
18. Hasegawa S., Nishi K., Watanabe A., Overstreet D.H., and Diksic M. Brain 5-HT synthesis in the Flinders sensitive line rat model of depression: an autoradiographic study. Neurochem. Int. 48 5 (2006) 358-366
19. Janowsky D.S., and Risch S.C. Cholinomimetics and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress. Drug Develop. Res. 4 (1984) 125-142
20. Kanemaru K., Hasegawa S., Nishi K., and Diksic M. Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats; an autoradiographic evaluation. Brain Res. Bull. 77 4 (2008) 214-220
21. Kelly J.P., Wrynn A.S., and Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol. Ther. 174 (1997) 299-316
22. Knapska E., Radwanska K., Werka T., and Kaczmarek L. Functional internal complexity of amygdala: focus on gene activity mapping after behavioral training and drugs of abuse. Physiol. Rev. 87 (2007) 1113-1173
23. Lapierre Y.D., and Butter H.J. Agitated and retarded depression. A clinical psychophysiological evaluation. Neuropsychobiology 6 (1980) 217-223
24. Lesch K.P., and Heils A. Serotonergic gene transcriptional control regions: targets for antidepressant drug development?. Int. J. Neuropsychopharmacol. 3 1 (2000) 67-79
25. Lumia A.R., Teicher M.H., Salchli F., Ayers E., and Possidente B. Olfactory bulbectomy as a model for agitated hyposerotonergic depression. Brain Res. 587 2 (1992) 181-185
26. Marcinkiewicz M., Vergé D., Gozlan H., Pichat L., and Hamon M. Autoradiographic evidence for the heterogeneity of 5-HT1 sites in the rat brain. Brain Res. 291 (1984) 159-163
27. Marcusson J., Oreland L., and Winblad B. Effect of age on human brain serotonin (S-1) binding sites. J. Neurochem. 43 (1984) 1699-1705
28. Markou A., Matthews K., Overstreet D.H., Koob G.F., and Geyer M.A. Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds. Biol. Psychiatry 36 (1994) 680-688
29. Meltzer C.C., Price J.C., Mathis C.A., Butters M.A., Ziolko S.K., Moses-Kolko E., Mazumdar S., Mulsant B.H., Houck P.R., Lopresti B.J., Weissfeld L.A., and Reynolds C.F. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 29 12 (2004) 2258-2265
30. Møller M., Jakobsen S., and Gjedde A. Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. Neuropsychopharmacology 32 8 (2007) 1707-1714
31. Nelson N. Presynaptic events involved in neurotransmission. J. Physiol. (Paris) 87 3 (1993) 171-178 (Review)
32. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., and Monteggia L.M. Neurobiology of depression. Neuron 34 (2002) 13-25
33. O'Neil M.F., and Moore N.A. Animal models of depression: are there any?. Human Psychopharmacol. Clin. Exp. 18 (2003) 239-254
34. Okazawa H., Yamane F., Blier P., and Diksic M. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. J. Neurochem. 72 (1999) 2022-2031
35. Olivier B., and Mos J. Rodent models of aggressive behavior and serotonergic drugs. Prog. Neuropsychopharmacol. Biol. Psychiatry 16 6 (1992) 847-870 (Review)
36. Overstreet D.H. Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists. Behav. Genet. 32 5 (2002) 335-348
37. Overstreet D.H., Daws L.C., Schiller G.D., Orbach J., and Janowsky D.S. Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression. Pharmacol. Biochem. Behav. 59 (1998) 777-785
38. Overstreet D.H., Friedman E., Mathé A.A., and Yadid G. The Flinders sensitive line rat: a selectively bred putative animal model of depression. Neurosci. Biobehav. Rev. 29 (2005) 739-759
39. Overstreet D.H., Stemmelin J., and Griebel G. Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacol. Biochem. Behav. 89 (2008) 623-626
40. Palacios J.M., Cortes R., and Dietl M.M. A laboratory guide for the in vivo labeling of receptors in tissue sections for radiography. In: Van Leeuwen F.W. (Ed). Molecular Neuroanatomy (1988), Elsevier, Amsterdam 95-109
41. Palacios J.M., Pazos A., and Hoyer D. Characterization and mapping of 5-HT1A sites in the brain of animals and man. In: Dourish C.T., Ahlenius S., and Hutson P.H. (Eds). Brain 5-HT1A Receptors (1987), Chichester, Horwood, VCH 65-81
42. Parks C.L., Robinson P.S., Sibille E., Shenk T., and Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 10734-10739
43. Parsey R.V., Oquendo M.A., Simpson N.R., Ogden R.T., Van Heertum R., Arango V., and Mann J.J. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res. 954 (2002) 173-182
44. Patton P.E., and McNaughton B. Connection matrix of the hippocampal formation. I. The dentate gyrus. Hippocampus 5 (1995) 245-286
45. Paxinos G., and Watson C. The Rat Brain Atlas in Stereotaxic Coordinates. Compact third edition (1997), Academic Press, New York
46. Pazos A., and Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346 (1985) 205-230
47. Piñeyro G., Deveault L., de Montigny C., and Blier P. Effect of prolonged administration of tianeptine on 5-HT neurotransmission: an electrophysiological study in the rat hippocampus and dorsal raphe. Naunyn Schmiedebergs Arch. Pharmacol. 351 (1995) 119-125
48. Plaznik A., Kostowski W., and Archer T. Serotonin and depression: old problems and new data. Prog. Neuropsychopharmacol. Biol. Psychiatry 13 5 (1989) 623-633 (Review)
49. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., and Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. U.S.A. 95 24 (1998) 14476-14481
50. Sargent P.A., Kjaer K.H., Bench C.J., Rabiner E.A., Messa C., Meyer J., Gunn R.N., Grasby P.M., and Cowen P.J. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57 (2000) 174-180
51. Sato H., Skelin I., Debonnel G., and Diksic M. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain Res. Bull. 75 (2008) 545-555
52. Schiller G.D. Altered behavioral sensitivity to serotonergic agonists in an animal model of depressive disorders: receptor binding correlates and cholineragic-serotonergic systems interaction. J. Neurochem. 57 (1991) S138
53. Shayit M., Yadid G., Overstreet D.H., and Weller A. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain Res. 980 (2003) 100-108
54. Srinivas B.N., Subhash M.N., and Vinod K.Y. Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain. Neurochem. Int. 38 7 (2001) 573-579
55. Stahl S. 5HT1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs?. Psychopharmacol. Bull. 30 1 (1994) 39-43 (Review)
56. Takeda N., Diksic M., and Yamamoto Y.L. The sequential changes in DNA synthesis, glucose utilization, protein synthesis, and peripheral benzodiazepine receptor density in C6 brain tumors after chemotherapy to predict the response of tumors to chemotherapy. Cancer 77 (1996) 1167-1179
57. Tohyama Y., Mück-Seler D., and Diksic M. Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an alpha-methyl-l-tryptophan autoradiographic study. Neurochem. Int. 51 8 (2007) 486-495
58. Tohyama Y., Yamane F., Fikre Merid M., Blier P., and Diksic M. Effects of serotonin receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. J. Neurochem. 80 5 (2002) 788-798
59. Tohyama Y., Yamane F., Merid M.F., and Diksic M. Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-l-tryptophan. Eur. Neuropsychopharmacol. 11 3 (2001) 193-202
60. van der Stelt H.M., Breuer M.E., Olivier B., and Westenberg H.G.M. Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study. Biol. Psychiatry 57 (2005) 1061-1067
61. Verge D., Daval G., Marcinkiewicz M., Patey A., el Mestikawy S., Gozlan H., and Hamon M. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 (1986) 3474-3482
62. Watanabe A., Hasegawa S., Nishi K., Nguyen K.Q., and Diksic M. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brian: an autoradiographic study. Brain Res. Bull. 69 (2006) 101-108
63. Watanabe A., Tohyama Y., Nguyen K.Q., Hasegawa S., Debonnel G., and Diksic M. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. J. Neurochem. 85 (2003) 469-475
64. Willner P., and Mitchell P.J. The validity of animal models of predisposition to depression. Behav. Pharmacol. 13 (2002) 169-188
65. Yadid G., Nakash R., Deri I., Tamar G., Kinor N., Gispan I., and Zangen A. Elucidation of the neurobiology of depression: insights from a novel genetic animal model. Prog. Neurobiol. 62 (2000) 353-378
66. Yamaguchi T., and Yamagata A. Serotonergic ligand binding in aging brain of experimental animals. Neurochem. Int. 16 4 (1991) 469-473
67. Zangen A., Nakash R., Overstreet D.H., and Yadid G. Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens. Psychopharmacology (Berl) 155 (2001) 434-439
68. Zangen A., Overstreet D.H., and Yadid G. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. J. Neurochem. 69 6 (1997) 2477-2483