Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists

Behavior Genetics

Volumn 32, Issue 5, 2002, Pages 335-348

  Overstreet, David H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT receptors; Antidepressants; Cholinergic receptors; Flinders Line rats; HDS and LDS line rats; Hypothermia; Swim test

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANTIDEPRESSANT AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; DESIPRAMINE; DEXAMPHETAMINE; FLUOXETINE; IMIPRAMINE; LITHIUM; MELATONIN; NEFAZODONE; NETAMIFTIDE; NICOTINE; PAROXETINE; PEPTIDE DERIVATIVE; S 20304; S 20938; SCOPOLAMINE; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; UNCLASSIFIED DRUG;

AFFECTIVE NEUROSIS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; BREEDING; DRUG ABUSE; FLINDERS RAT STRAIN; GENETIC SUSCEPTIBILITY; HYPOTHERMIA; INBRED STRAIN; NEUROCHEMISTRY; NONHUMAN; PHENOTYPE; RAT; RAT STRAIN; REVIEW; STRAIN DIFFERENCE; STRESS; SWIMMING;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BEHAVIOR, ANIMAL; CHOLINERGIC AGONISTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; GENETICS, BEHAVIORAL; HYPOTHERMIA; ISOFLUROPHATE; RATS; RATS, INBRED STRAINS; RECEPTORS, CHOLINERGIC; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SELECTION (GENETICS); SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS;

ANIMALIA;

EID: 0036750615     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020262205227     Document Type: Review

References (97)

1. Agabio, R., Carai, M. A., Lobina C., Pani, M., Reali, R., Brov, I., Gessa, G. L., and Colombo, G. (2000). Dissociation of ethanol and saccharin preference in SP and sNP rats. Alcohol. Clin. Exp. Res. 24:24-29.
2. Arango, V., Underwood, M. D., Gobbi, A. V., and Mann, J. J. (1995). Localized alteration in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res. 688:121-133.
3. Auta, J., Lecca, D., Nelson, M., Guidotti, A., Overstreet, D. H., Costa, E., and Javaid, J. I. (2000). Expression and function of striatal nAChRs differ in the Flinders sensitive (FSL) and resistant (FRL) rat lines. Neuropharmacology 39:2624-2631.
4. Benca, R. M., Obermeyer, W. H., Thisted, R. A., and Gillin, J. C. (1992). Sleep and psychiatric disorders: A meta analysis. Arch. Gen. Psychiatry 29:651-668.
5. Benca, R. M., Overstreet, D. H., Gilliland, M. A., Russell, D., Bergmann, B. M., and Obermeyer, W. H. (1996). Increased basal REM sleep but no difference in dark induction or light suppression of REM sleep in Flinders rats with cholinergic supersensitivity. Neuropsychopharmacology 15:45-51.
6. Borsini, F., and Meli, A (1988). Is the forced swimming test a valid predictor of antidepressant action? Psychopharmacology 94:47-160.
7. Bristow, L. J., O'Connor, D., Watts, R., Duxon, M. S., and Hutson, P. H. (2000). Evidence for accelerated desensitization of 5-HT(2C) receptors following combined treatment with fluoxetine and the 5-HT(1A) receptor antagonist, WAY 100,635, in the rat. Neuropharmacology 39:1222-1226.
8. Bushnell, P. J., Levin, E. D., and Overstreet, D. H. (1995). Spatial working and reference memory in rats bred for differential sensitivity to cholinesterase inhibition: Acquisition, accuracy, speed, and effects of cholinergic drugs. Neurobiol. Learn. Mem. 63:116-132.
9. Caberlotto, L., Fuxe, K., Overstreet, D. H., Gerrard, P., and Hurd, Y. L. (1998). Alterations in Neuropeptide Y and Y1 receptor mRNA expression in brains of an animal model of depression: Region specific adaptation after fluoxetine treatment. Molec. Brain Res. 59:58-65.
10. Crocker, A. D., and Overstreet, D. H. (1991). Changes in dopamine sensitivity in rats selectively bred for differences in cholinergic function. Pharmacol. Biochem. Behav. 38:105-108.
11. 1A-induced hypothermia. Pharmacol. Biochem. Behav. 67:199-205.
12. 1A receptor stimulation: Differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs. J. Pharmacol. Exp. Ther. 292:104-113.
13. Daws, L. C., and Overstreet, D. H. (1999). Ontogeny of muscarinic cholinergic supersensitivity in the Flinders Sensitive Line rat. Pharmacol. Biochem. Behav. 62:367-380.
14. Daws, L. C., Schiller, G. D., Overstreet, D. H., and Orbach, J. (1991). Early development of muscarinic supersensitivity in a genetic animal model of depression. Neuropsychopharmacology 4:207-217.
15. Dess, N. K., Badia-Elder, N. E., Thiele, T. E., Kiefer, S. W., and Blizard, D. A. (1998). Ethanol consumption in rats selectively bred for differential saccharin intake. Alcohol 16:275-278.
16. Detke, M. J., Wieland, S., and Lucki, I. (1995). Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5-HT-1A receptor antagonists. Psychopharmacology 119:41-54.
17. Dilsaver, S. C., Peck, J. A., and Overstreet, D. H. (1992). The Flinders Sensitive Line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat. Pharmacol. Biochem. Behav. 41:23-27.
18. Djuric, V. J., Overstreet, D. H., Bienenstock, J., and Perdue, M. H. (1995). Immediate hypersensitivity in the Flinders rat: Further evidence for a link between susceptibility to allergies and depression. Brain Behav. Immun. 9:196-206.
19. Djuric, V. J., Cox, G., Overstreet, D. H., Smith, L., Dragomir, A., and Steiner, M. (1998), Genetically transmitted cholinergic hyperresponsiveness predisposes to experimental asthma. Brain Behav. Immun. 12:272-284.
20. Djuric, V. J., Dunn, E., Overstreet, D. H., Dragomir, A., and Steiner, M. (1999). Antidepressant effect of ingested nicotine in female rats of Flinders Resistant and Sensitive Lines. Physiol. Behav. 67:533-537.
21. Feighner, J. P., Sverdlov, L., Nicolau, G., and Noble, J. F. (2000). Cluster analysis of clinical data to identify subtypes within a study population following treatment with a new pentapeptide antidepressant. Inter. J. Neuropsychopharmacol. 3:237-242.
22. 1A receptor function. Pharmacol. Biochem. Behav. 62:695-701.
23. 1A receptor function: A link between anxiety and depression? Pharmacol. Biochem. Behav. 59:787-792.
24. 1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology 91:500-505.
25. Gosnell, B. A., and Krahn, D. (1992). The relationship between saccharin and alcohol intake in rats. Alcohol 9:203-206.
26. Hansen, C., and Spuhler, K. (1984). Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol. Exp. Clin. Res. 8:477-479.
27. Hensler, J. G., and Durgam, H. (2001). Regulation of 5-HT1A receptor-stimulated [35S]GTPgS binding as measured by quantitative autoradiography following chronic agonist administration. Br. J. Pharmacol. 132:605-611.
28. Hjorth, S. (1985). Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT. J. Neural Transm. 61:131-135.
29. Hlavka J., Abajian, H. B., Morrison, J., Overstreet, D., Kelly J., Nicolau G., Sverdlov, L., and Feighner, J. P. (2002). Chemistry and pharmacology of nemifitide, a novel antidepressant peptide. XXII CINP Congress, Montreal, Canada, June 23-27.
30. Janowsky, D. S., and Overstreet, D. H. (1996). Anti-immobility effects of fluoxetine and desipramine in rats selectively bred for high sensitivity to 8-OH-DPAT. Presented at 26th Annual Meeting of Society for Neuroscience, Washington, D. C., November 16-21, Abstract #76.12.
31. Janowsky, D. S., Overstreet, D. H., and Nurnberger, J. I. Jr. (1994). Is cholinergic sensitivity a genetic marker for the affective disorders? Am. J. Med. Genet. Neuropsychiatric Genet. 54:335-344.
32. Jimenez-Vazquez, P. A., Overstreet, D. H., and Mathe, A. A. (2000). Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression: Effects of electroconvulsive stimuli. J. Psychiatric Res. 34:405-412.
33. Jolly, D. C., Richards, J. B., and Seiden, L. S. (1999). Serotonergic mediation of DRL 72-s behavior: Receptor subtype involvement in a behavioral screen for antidepressant drugs. Biol. Psychiatry 45:1151-1162.
34. Kampov-Polevoy, A. B., Kasheffskaya, R. P., and Sinclair, J. D. (1990). Initial acceptance of ethanol: Gustatory factors and patterns of alcohol drinking. Alcohol 7:115-120.
35. Kaufman, C. A., Gillin, J. C., Hill, B., O'Laughlin, T., Phillips, I., Gleenman, J. E., and Wyatt, R. J. (1984). Muscarinic binding in suicides. Psychiatry Res. 12:47-56.
36. Kennett, G. A., Wood, M. D., Bright, F., Trail, B., Riley, G., Holland, V., Avenell, K. Y., Stean, T., Upton, N., Bromidge, S., Forbes, I. T., Brown, A. M., Middlemiss, D. N., and Blackburn, T. P. (1997). SB 242084: A selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36:609-620.
37. 1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity. Brain Res. 782:1-10.
38. Knapp, D. J., Sim-Selley, L. J., Breese, G. R., and Overstreet, D. H. (2000). Selective breeding of 5-HT(IA) receptor-mediated responses: Application to emotion and receptor action. Pharmacol. Biochem. Behav. 67:701-708.
39. 1A receptor responsivity in anxiety disorders and depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 15:723-733.
40. 1A receptor function in depression: Effect of chronic amitriptyline treatment. J. Neur. Transm. 80:157-61.
41. Liebsch, G., Montkowski, A., Holsboer, F., and Landgraf, R. (1998). Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour. Behav. Brain Res. 94:301-310.
42. Meyerson, L. R., Wenogle, L. P., Abel, M. S., Cupet, J., Lippa, A. S., Rough, C. E., and Beer, B. (1982). Human brain receptor alterations in suicide victims. Pharmacol. Biochem. Behav. 17:159-163.
43. Mikuno, M., Kusumi, I., Kagawa, A., Kuroda, Y., Mori, H., and Takahashi, K. (1991). Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 15:49-62.
44. O'Connell, M. T., Sarna, G. S., and Curzon, G. (1992). Evidence for postsynaptic mediation of the hypothermic effect of 5-HT-1A receptor activation. Br. J. Pharmacol. 106:603-609.
45. Overstreet, D. H. (1986). Selective breeding for increased cholinergic function: Development of a new animal model of depression. Biol. Psychiatry 21:49-58.
46. Overstreet, D. H. (1993). The Flinders Sensitive Line Rats: A genetic animal model of depression. Neurosci. Biobehav. Rev. 17:51-68.
47. Overstreet, D. H., and Russell, R. W. (1982). Selective breeding for sensitivity to DFP: Effects of cholinergic agonists and antagonists. Psychopharmacology 78:150-154.
48. Overstreet, D. H., and Djuric, V. (1999). Links between multiple chemical sensitivity and asthma in a rat model of cholinergic hypersensitivity: A brief review. Toxicol. Indust. Health 15:517-521.
49. Overstreet, D. H., Russell, R. W., Helps, S. C., and Messenger, M. (1979). Selective breeding for sensitivity to the anticholinesterase, DFP. Psychopharmacology 65:15-20.
50. Overstreet, D. H., Russell, R. W., Crocker, A. D., and Schiller, G. D. (1984). Selective breeding for differences in cholinergic function: Pre- and post-synaptic mechanisms involved in sensitivity to the anticholinesterase, DFP. Brain Res. 294:327-332.
51. Overstreet, D. H., Double, K., and Schiller, G. D. (1989a). Antidepressant effects of rolipram in a genetic animal model of depression: Cholinergic supersensitivity and weight gain. Pharmacol. Biochem. Behav. 34:691-696.
52. Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1989b). Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity. Alcohol Alcohol. 25:59-65.
53. Overstreet, D. H., Janowsky, D. S., and Rezvani, A. H. (1990a). Impaired active avoidance responding in rats selectively bred for increased cholinergic function. Physiol. Behav. 47:787-788.
54. Overstreet, D. H., Dilsaver, S. C., Janowsky, D. S., and Rezvani, A. H. (1990b). Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function. Psychiatr. Res. 33:149-150.
55. Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1992a). Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. Biol. Psychiatr. 31:919-936.
56. Overstreet, D. H., Russell, R. W., Hay, D. A., and Crocker, A. D. (1992b). Selective breeding for increased cholinergic function: Biometrical genetic analysis of muscarinic responses. Neuropsychopharmacology 7:197-204.
57. Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1992c). Maudsley Reactive and Nonreactive rats differ only in some tasks reflecting emotionality. Physiol. Behav. 52:149-152.
58. Overstreet, D. H., Kampov-Polevoy, A. B., Rezvani, A. H., Murrelle, L., Halikas, J. A., and Janowsky, D. S. (1993). Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol. Clin. Exp. Res. 17:366-369.
59. Overstreet, D. H., Janowsky, D. S., Pucilowski, O., and Rezvani, A. H. (1994a). Swim test immobility cosegregates with serotonergic but not cholinergic sensitivity in cross breeds of Flinders Line rats. Psychiatr. Genet. 4:101-107.
60. Overstreet, D. H., Rezvani, A. H., Pucilowski, O., Gause, L., and Janowsky, D. S. (1994b). Rapid selection for serotonin-1A sensitivity in rats. Psychiatr. Genet. 4:57-62.
61. Overstreet, D. H., Pucilowski, O., Rezvani, A. H., and Janowsky, D. S. (1995). Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. Psychopharmacology 121:27-37.
62. Overstreet, D. H., Rezvani, A. H., Knapp, D. J. Crews, F. T., and Janowsky, D. S. (1996). Further selection of rat lines differing in 5-HT-1A receptor sensitivity: Behavioral and functional correlates. Psychiatr. Genet. 6:107-117.
63. Overstreet, D. H., Halikas, J. A., Seredinin, S. B., Kampov-Polevoy, A. B., Viglinskaya, I. V., Kashevskaya, O., Badishtov, B. A., Knapp, D. J., Mormede, P., Kiianmaa, K., Li, T.-K., and Rezvani, A. H. (1997). Behavioral similarities and differences among alcohol preferring and nonpreferring rats: Confirmation by factor analysis and extension to additional groups. Alcohol. Clin. Exp. Res. 21:840-848.
64. Overstreet, D. H., Daws, L. C., Schiller, G. D., Orbach, J., and Janowsky, D. S. (1998a). Cholinergic/serotonergic interactions in hypothermia: Implications for rat models of depression. Pharmacol. Biochem. Behav. 59:777-785.
65. Overstreet, D. H., Pucilowski, O., Rettori, M.-C., Delagrange, P., and Guardiola-Lemaitre, B. (1998b). Anti-immobility effects of a melatonin receptor agonist, but not antagonist, in a genetic animal model of depression. NeuroReport 9:249-253.
66. Overstreet, D. H., Janowsky, D. S., Hlavka, J., Morrison, J., and Abajian, H. (2001). Antidepressant properties of a pentapeptide in an animal model of depression. Presented at Annual Meeting of Society for Neuroscience, San Diego, CA, November 9-13, Abstract #665.6.
67. Pellow, S., Chopin, P., File, S. E., and Briley, M. (1985). Validation of open-closed arm entries in an Elevated Plus-Maze as a measure of anxiety in the rat. J. Neurosci. Meth. 14:149-167.
68. Pepe, S., Overstreet, D. H., and Crocker, A. D. (1988). Enhanced benzodiazepine responsiveness in rats with increased cholinergic function. Pharmacol. Biochem. Behav. 31:15-20.
69. Porsolt, R. D., Anton, G., Blavet, N., and Jalfre, M. (1977). Behavioral despair in rats: A new model sensitive to anti-depressant treatments. Eur. J. Pharmacol. 47:379-391.
70. Pucilowski, O., and Overstreet, D. H. (1993). Effect of chronic antidepressant treatment on responses to apomorphine in selectively bred rat strains. Brain Res. Bull. 32:471-475.
71. Pucilowski, O., Overstreet, D. H., Rezvani, A. H., and Janowsky, D. S. (1993). Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression. Physiol. Behav. 54:1215-1220.
72. Ramos, A., Berton, O., Mormede, P., and Chaouloff, F. (1997). A multiple-test study of anxiety-related behaviours in six inbred rat strains. Behav. Brain Res. 85:57-69.
73. Risch, S. C., Kalin, N. H., and Janowsky, D. S. (1991). Cholinergic challenge in affective illness: Behavioral and neuroendocrine correlates. J. Clin. Psychopharmacol. 1:186-192.
74. Russell, R. W., and Overstreet, D. H. (1987). Mechanisms underlying sensitivity to organophosphorus anticholinesterase agents. Prog. Neurobiol. 28:97-129.
75. Russell, R. W., Overstreet, D. H., Messenger, M., and Helps, S. C. (1982). Selective breeding for sensitivity to DFP: Generalization of effects beyond criterion variables. Pharmacol. Biochem. Behav. 17:885-891.
76. Salin-Pascual, R. J., de la Fuente, J. D., Galicia-Polo, I., and Drucker-Colin, R. (1995). Effects of transdermal nicotine on mood and sleep in nonsmoking major depressed patients. Psychopharmacology 121:476-479.
77. Schiller, G. D. (July, 1991). Altered behavioral sensitivity to serotonergic agonists in an animal model of depressive disorders: Receptor binding correlates and cholinergic-serotonergic systems interaction. Presented at International Society for Neurochemistry, Sydney, Australia.
78. Schiller, G. D., and Overstreet, D. H. (1993). Selective breeding for increased cholinergic function: Preliminary study of nicotinic mechanisms. Med. Chem. Res. 2:578-583.
79. Schiller, G. D., Daws, L. C., Overstreet, D. H., and Orbach, J. (1991). Absence of anxiety in an animal model of depression with cholinergic supersensitivity. Brain Res. Bull. 26:443-447.
80. Schiller, G. D., Pucilowski, O., Wienicke, C., and Overstreet, D. H. (1992). Immobility-reducing effects of antidepressants in a genetic animal model of depression. Brain Res. Bull. 28:821-823.
81. Schreiber, W., Lauer, D. J., Krumrey, K., Holsboer, F., and Krieg, J. C. (1992). Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders. Biol. Psychiatry 32:79-90.
82. Semba J., Mataki, C., Yamada, S., Nankai, M., and Toru, M. (1998). Antidepressant-like effects of chronic nicotine on learned helplessness paradigms in rats. Biol. Psychiatry 43:389-391.
83. Shiromani, P. J., Overstreet, D. H., Levy, D., Goodrich, C. A., Campbell, S. S., and Gillin, J. C. (1988). Increased REM sleep in rats selectively bred for cholinergic hyperactivity. Neuropsychopharmacology 1:127-133.
84. Shiromani, P. J., Overstreet, D. H., and Lucero, S. (1990). Failure of dietary lithium to alter immobility in an animal model of depression. Lithium 1:241-244.
85. Shiromani, P. J., and Overstreet, D. H. (1994). Free-running period of the circadian drinking rhythm is shorter in rats with an upregulated central cholinergic system. Biol. Psychiatry 36:622-626.
86. Sihotang, K., and Overstreet, D. H. (1983). Studies on the possible relationship of brain proteins to behavioral sensitivity to DFP. Life Sci. 32:413-420.
87. 35S]thio-triphosphate binding. Proc. Nat. Acad. Sci. USA 92:7242-7246.
88. gS autoradiography in rat brain. J. Neurosci. 16:2684-2692.
89. Sinclair, J. D., Kampov-Polevoy, A., Stewart R., and Li, T.-K. (1992). Taste preferences in rat lines selected for low and high alcohol consumption. Alcohol 9:155-160.
90. Tizabi, Y., Overstreet, D. H., Rezvani, A. H., Louis, V. A., Clark, E. Jr., Janowsky, D. S., and Kling, M. A. (1999). Antidepressant effects of nicotine in an animal model of depression. Psychopharmacology 142:193-199.
91. Tizabi, Y., Rezvani, A. H., Russell, L. T., Tyler, K. Y., and Overstreet, D. H. (2000). Depressive characteristics of FSL rats: Involvement of central nicotinic receptors. Pharmacol. Biochem. Behav. 66:73-77.
92. Wallis, E., Overstreet, D. H., and Crocker, A. D. (1988). Selective breeding for increased cholinergic function: Increased serotonergic sensitivity. Pharmacol. Biochem. Behav. 31:345-350.
93. Yadid, G., Zangen, A., Dmitrochenko, A., Overstreet, D. H., and Zohar, J. (2000). Screening for new antidepressants with fast onset and long-lasting action. Drug Dev. Res. 50:392-399.
94. Yadid, G., Overstreet, D. H., and Zangen, A. (2001). Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression. Brain Res. 896:43-47.
95. Zangen, A., Overstreet, D. H., and Yadid, G. (1997). High serotonin and 5-hydroxyindoleacetic acid levels in limbic regions of a rat model of depression: Normalization by chronic antidepressant treatment. J. Neurochem. 69:2477-2483.
96. Zangen, A., Overstreet, D. H., and Yadid, Y. (1998). Increased catecholamine levels in specific brain regions of a rat model of depression: Normalization by chronic antidepressant treatment. Brain Res. 824:243-250.
97. Zangen, A., Nakash, R., Overstreet, D. H., and Yadid, G. (2001). Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens. Psychopharmacology 155:434-439.