Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: An autoradiographic study with α-[14C]methyl-L-tryptophan

European Neuropsychopharmacology

Volumn 11, Issue 3, 2001, Pages 193-202

  Tohyama, Yoshihiro ^a   Yamane, Fumitaka ^a   Merid, Maraki Fikre ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

methyl L tryptophan; 5 HT1A receptor antagonists; Autoradiography; Serotonin synthesis rate; WAY100135; WAY100635

Indexed keywords

AUTORECEPTOR; CARBON 14; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N METHYLTRYPTOPHAN; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PARTIAL AGONIST; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN; CONTROLLED STUDY; MALE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SYNTHESIS;

ANIMALS; AUTORADIOGRAPHY; BRAIN; MALE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN ANTAGONISTS; TRYPTOPHAN;

EID: 0034953482     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(01)00076-1     Document Type: Article

References (52)

1. Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats
2. Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties
3. An autoradiographic analysis of the differential ascending projections of the dorsal and medial raphe nuclei in the rat
4. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain
5. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe
6. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex
7. 11C]methyl-L-tryptophan positron emission tomography
8. Human brain serotonin synthesis capacity measured in vivo with α-[C-11]methyl-L-tryptophan
9. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children
10. Increased brain serotonin synthesis in migraine
11. α[C-11]Methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism
12. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex
13. A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model
14. Autoradiographic measurement of the rate of serotonin synthesis in the rat brain
15. The regional rate of serotonin synthesis estimated by the α-methyl-tryptophan method in rat brain from a single time point
16. Is alpha -methyl-L-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain?
17. Does labelled α-methyl-L-tryptophan image ONLY blood-brain barrier transport of tryptophan?
18. 14C]methyl-L-tryptophan (α-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and α-MTrp
19. Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe
20. Identity of inhybitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites
21. Characterization of the serotonin1A receptor antagonist activity of WAY100135 and spiperone
22. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors
23. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY100635, a potent, selective and silent 5-HT1A receptor antagonist
24. WAY100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY100135
25. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY100635
26. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT
27. 1B sites
28. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor
29. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis
30. Administration of 8-hydroxy-2-(Di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity
31. Characterisation of the binding of [3H]WAY100635 a novel 5-hydroxytryptamine1A receptor antagonist, to rat brain
32. Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY100135 and SDZ 216-525
33. In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine
34. Regional differences in the effect of the combined treatment of WAY100635 and fluoxetine: An in vivo microdialysis study
35. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis
36. The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method
37. DL-fenfluramine increases the 5-HT synthesis rate in the terminals while decreasing it in the cell bodies of the rat brain
38. Influence of fluoxetine on regional serotonin synthesis in the rat brain
39. Serotonin synthesis increased in terminals 4 days after reserpine treatment: an autoradiographic study in rat brain
40. The effect of MDMA (3,4-methylenedioxymethamphetamine) on the 5-HT synthesis rate in the rat brain: An autoradiographic study
41. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing
42. Synthesis of enantiomerically pure α-[14C]methyl-L-tryptophan
43. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats
44. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain
45. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
46. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors
47. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo
48. 14C] labeled tracer
49. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists
50. Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding
51. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis
52. 5-Hydroxytryptamine receptors