Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: Results of an autoradiographic study

Neurochemistry International

Volumn 46, Issue 3, 2005, Pages 261-272

  Hasegawa, Shu ^a   Watanabe, Arata ^a   Nishi, Kyoko ^a   Nguyen, Khanh Q ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

14C Methyl l tryptophan; 5 HT1B receptor agonist; Autoradiography; Serotonin synthesis rate

Indexed keywords

3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; AUTORECEPTOR; RADIOISOTOPE; SEROTONIN 1B AGONIST; TRYPTOPHAN DERIVATIVE; 3 (1,2,5,6 TETRAHYDROPYRID 4 YL)PYRROLO(3,2 B)PYRID 5 ONE; 3-(1,2,5,6-TETRAHYDROPYRID-4-YL)PYRROLO(3,2-B)PYRID-5-ONE; ALPHA-METHYLTRYPTOPHAN; DRUG DERIVATIVE; N METHYLTRYPTOPHAN; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SEROTONIN; SEROTONIN 1B RECEPTOR; SEROTONIN AGONIST; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; EVALUATION; ISOTOPE LABELING; MALE; MEDIAN RAPHE NUCLEUS; NERVE ENDING; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX; SEROTONIN RELEASE; STATISTICAL SIGNIFICANCE; VISUAL CORTEX; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; CAPILLARY; DRUG EFFECT; INFUSION PUMP; KINETICS; METABOLISM; NERVE TRACT; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; CAPILLARIES; INFUSION PUMPS, IMPLANTABLE; KINETICS; MALE; NEURAL PATHWAYS; PYRIDINES; PYRROLES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN; SEROTONIN AGONISTS; TIME FACTORS; TRYPTOPHAN;

EID: 12744267901     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2004.08.007     Document Type: Article

References (65)

1. 1B receptors in the regulation of serotonin cell firing and release in the rat brain J. Neurochem. 79 2001 172 182
2. S.B. Auerbach, J.J. Rutter, and P.J. Juliano Substituted piperazine and indole compounds increase extracellular serotonin in rat diencephalon as determined by in vivo microdialysis Neuropharmacology 30 1991 307 311
3. D.L. Bloxam, and G. Curzon A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation J. Neurochem. 31 1978 1255 1263
4. F.G. Boess, and I.L. Martin Molecular biology of 5-HT receptors Neuropharmacology 33 1994 275 317
5. U. Boschert, D.A. Amara, L. Segu, and R. Hen The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals Neuroscience 58 1994 167 182
6. 1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats Psychopharmacology 117 1995 358 363
7. T.D. Brewerton Toward a unified theory of serotonin dysregulation in eating and related disorders Psychoneuroendocrinology 20 1995 561 590
8. 1B/1D Receptors 1997 Springer-Verlag Berlin
9. W.F. Byerley, and S.C. Risch Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment J. Clin. Psychopharmacol. 15 1985 191 206
10. W.P. Daugherty, K.C. Corley, T.-H. Phan, and M.C. Boadle-Biber Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress Brain Res. 923 2001 103 111
11. M. Diksic Does labeled α-methyl-l-tryptophan image ONLY blood-brain barrier transport of tryptophan? J. Cereb. Blood Flow Metabol. 20 2000 1508 1511
12. M. Diksic, S. Nagahiro, T.L. Sourkes, and Y.L. Yamamoto A new method to measure brain serotonin synthesis in vivo: I. Theory and basic data for a biological model J. Cereb. Blood Flow Metabol. 10 1990 1 12
13. M. Diksic, M. Leyton, and C. Benkelfat Is α-methyl-l-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain? J. Neurochem. 73 1999 2621 2624
14. M. Diksic, S. Nagahiro, and M. Grdisa The regional rate of serotonin synthesis estimated by the α-methyl-l-tryptophan method in rat brain from single time point J. Cereb. Blood Flow Metabol. 15 1995 806 813
15. 14C]methyl-l-tryptophan (α-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and α-MTrp Neurochemem. Res. 25 2000 1537 1546
16. M. Diksic, and S.N. Young Study of the brain serotonergic system with labelled α-methyl-l-tryptophan J. Neurochem. 78 2001 1 17
17. M. Diksic Labelled α-methyl-l-tryptophan as tracer to study brain serotonergic system J. Psychiatry Neurosci. 26 2001 293 303
18. R.P. Dilts, and M.C. Boadle-Biber Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound Neurosci. Lett. 199 1995 78 80
19. C.M. Dixon, D.A. Saynor, P.D. Andrew, J. Oxford, A. Bradbury, and M.H. Tarbit Disposition of sumatriptan in laboratory animals and humans Drug Metabol. Disposit. 21 1993 761 769
20. C.F. Dobson, Y. Tohyama, M. Diksic, and E. Hamel Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain Cephalalgia 24 2004 2 11
21. 1B receptor in serotoninergic neurons of anterior raphe nuclei in the rat brain Synapse 19 1995 18 28
22. 1B binding sites Naunyn-Schmiedebergs Arch. Pharmacol. 332 1986 1 7
23. 1B knock-out mice J. Neurosci. 11 1999 3823 3831
24. A. Gharib, C. Balende, N. Sarda, D. Weissmann, A. Plenevaux, A. Luxen, P. Bobillier, and J.F. Pujol Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the α-methyl-l-tryptophan method J. Neurochem. 72 1999 2593 2600
25. R. Hen Of mice and flies: commonalties among 5-HT receptors Trends Pharm. Sci. 13 1992 160 165
26. G.H. Heninger Indoleamine: the role of serotonin in clinical disorders F.E. Bloom D.J. Kupfer Psychopharmacology: The Fourth Generation of Progress 1995 Raven Press New York 471 482
27. P. Hertel, N. Lindblom, G.G. Nomikos, and T.H. Svensson Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus Psychopharmacology 153 2001 307 314
28. 1B receptor agonist CP-93, 129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969 Eur. J. Pharmacol. 209 1991 249 252
29. S. Hjorth, C.S. Suchowski, and M.P. Galloway Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain Synapse 19 1995 170 176
30. 1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei Neuropharmacology 40 2001 508 519
31. 1B) agonist that promotes satiety Psychopharmacology 131 1997 264 270
32. R.C. Lin, E. Costa, N.H. Neff, C.T. Wang, and S.H. Ngai In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine J. Pharmacol. Exp. Ther. 170 1969 232 238
33. 1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole J. Med. Chem. 33 1990 2087 2093
34. G.R. Martin, and P.P.A. Humpherey Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature Neuropharmacology 33 1994 261 273
35. G. Maura, and M. Raiteri Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release Eur. J. Pharmacol. 129 1986 333 337
36. 1) receptor agonist CP 93,129 Br. J. Pharmacol. 125 1998 1726 1732
37. D. Mück-Šeler, A. Jevric-Causevic, and M. Diksic Influence of fluoxetine on regional serotonin synthesis in rat brain J. Neurochem. 67 1996 2434 2442
38. 14C] methyl-l-tryptophan Appl. Radiat. Isot. 44 1993 1167 1172
39. S. Nagahiro, A. Takada, M. Diksic, T.L. Sourkers, K. Missala, and Y.L. Yamamoto A new method to measure brain serotonin synthesis in vivo. Part 2: A practical autoradiographic method tested in normal and lithium-treated rats J. Cereb. Blood Flow Metabol. 10 1990 13 21
40. H. Okazawa, F. Yamane, P. Blier, and M. Diksic Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain J. Neurochem. 72 1999 2022 2031
41. A. Pazos, and J.M. Palacios Quantitative autoradiographic mapping of serotonin receptors in the rat brain. Serotonin-1 receptors Brain Res. 343 1985 403 408
42. 1B receptor knock out behavioral consequences Behav. Brain Res. 73 1996 305 312
43. 1B antimigraine drug receptor in rat and human brain vessels Neuroscience 86 1998 1031 1035
44. C. Roberts, G.W. Price, and D.N. Middlemiss Ligands for the investigation of 5-HT autoreceptor function Brain Res. Bull. 56 2001 463 469
45. M. Salter, R.G. Knowles, and C.L. Aogson How dose displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydorxytryptamine synthesis in the brain? Biochem. J. 262 1989 365 368
46. H. Sarhan, I. Cloez-Tayarani, O. Massot, M.P. Fillion, and G. Fillion 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes Naunyn-Schmiedebergs Arch. Pharmacol. 359 1999 40 47
47. 1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies Neuroscience 88 1999 899 915
48. D. Schirlin, F. Gerhart, J.M. Hornsperger, M. Hamon, J. Wagner, and M.J. Jung Synthesis and biological properties of mono- and difluoromethyl-derivatives of tryptophan and 5-hydroxytryptophan J. Med. Chem. 31 1988 30 36
49. 1B receptor agonist Soc. Neurosci. Abstr. 16 Part 2 1990 1035
50. J. Schubert Labelled 5-hydroxytryptamine and 5-hydroxyindoleacetic acid formed in vivo from 3H-tryptophan in rat brain effect of probenecid Acta Physiol. Scand. 90 1974 401 418
51. S.E. Shoaf, and B. Schmall Pharmacokinetics of α-methyl-l- tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis J. Pharmacol. Exp. Ther. 277 1996 219 224
52. 14C]labeled tracer J. Cereb. Blood Flow Metabol. 20 2000 244 252
53. 1 receptor Eur. J. Pharmacol. 157 1988 173 181
54. A.J. Sleight, R.J. Smith, C.A. Marsden, and M.G. Palfreyman The effects of chronic treatment with amitriptyline and MDL 72394 on the control of 5-HT release in vivo Neuropharmacology 28 1989 477 480
55. 1B agonists Synapse 1 1987 3 9
56. 2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro J. Neurosci. 16 1996 7566 7573
57. A. Takada, M. Grdisa, M. Diksic, A. Gjedde, and Y.L. Yamamoto Rapid steady-state analysis of brain blood-brain transfer of l-Trp in rat, with special reference to the plasma protein binding Neurochem. Int. 23 1993 351 359
58. E. Tanaka, and R.A. North Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex J. Neurophysiol. 69 1993 1749 1757
59. R. Tao, and S.B. Auerbach Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain Neuroscience 68 1995 553 561
60. Y. Tohyama, F. Yamane, M. Fikre Merid, P. Blier, and M. Diksic Effects of serotonin receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study J. Neurochem. 80 2002 788 798
61. H.M. van Praag Anxiety and aggression as pacemakers of depression: a dimensional variation of the serotonin hypothesis of depression J. Mendlewicz G. Racagni N. Brunello Current Therapeutic Approaches to Panic and Other Anxiety Disorders 1994 Karger Basel 144 150
62. M. van Wijk, J.B. Sebens, and J. Korf Probenecid-induced increase of 5-hydroxytryptamine synthesis in rat brain, as measured by formation of 5-hydroxytryptophan Psychopharmacology 60 1979 229 235
63. M. Vanier, K. Tsuiki, M. Grdisa, K. Worsly, and M. Diksic Determination of the lumped constant for the a-methyl tryptophan method of estimating the rate of serotonin synthesis J. Neurochem. 6 1995 624 635
64. M.M. Voigt, D.J. Laurie, P.H. Seeburg, and A. Bach Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor EMBO J. 10 1991 4017 4023
65. F. Yamane, Y. Tohyama, and M. Diksic Acute and chronic d-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study Neurochem. Res. 24 1999 1611 1620