Stereoselective synthesis of highly functionalised pyrrolidines via 1,3-dipolar cycloaddition reactions on a solid support

Tetrahedron Letters

Volumn 37, Issue 51, 1996, Pages 9157-9160

  Hollinshead, Sean P ^a  

^a Sphinx Pharmaceuticals Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; REACTION ANALYSIS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0030590979     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02147-8     Document Type: Article

References (20)

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17. 7. For example, compound 4a was prepared according to the following scheme: (equation presented)
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19. 9. AgOAc reportedly affords higher stereoselectivity in some cases as compared to LiBr (see ref. 5) and is sometimes the favored catalyst (see refs. 2a-c). For most examples to date the major diastereisomer has been formed with > 85% selectivity when LiBr has been employed as the Lewis acid.
20. 2O: C 70.22. H 5.81. N 2.92. Found C 70.52. H 6.05. N 2.85.