KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 215-224

  Park, Pil Hoon ^a   Kim, Hak Sung ^a   Jin, Xing Yu ^a   Jin, Feng ^a   Hur, Jin ^a   Ko, Geonil ^a   Sohn, Dong Hwan ^a  

^a Medicinal Resources Research Institute   (South Korea)

Author keywords

Chalcone; Heme oxygenase 1; Inflammation; Lipopolysaccharide; Nitric oxide

Indexed keywords

3 PHENYL 1 [2,4,6 TRIS(METHOXYMETHOXY)PHENYL]PROP 2 YN 1 ONE; CHALCONE DERIVATIVE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KB 34; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; NITRIC OXIDE; PROTOPORPHYRIN TIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG SYNTHESIS; ENZYME INDUCTION; ENZYME INHIBITION; INHIBITION KINETICS; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CHALCONE; ENZYME INDUCTION; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 60949091762     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.034     Document Type: Article

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